Datasets:

jameshyojaelee
/

masld-atlas-data

human_symbol stringlengths 2 25	ensembl_id stringlengths 15 15	gene_biotype stringclasses 33 values	mouse_ortholog stringlengths 18 18 ⌀	bulk_logFC float64 -1.73 3.48	bulk_padj float64 0 1	bulk_tstat float64 -16.27 17.2	bulk_shrunk_logFC float64 -1.67 3.32	bulk_lfsr float64 0 0.59	bulk_sig bool 2 classes	treat_lfc float64 0.25 0.25	treat_p float64 0 1	treat_fdr float64 0 1	is_deg bool 2 classes	bulk_logFC_M float64 -1.69 3.64	bulk_logFC_F float64 -1.89 3.67	sex_class stringclasses 3 values	sex_interaction_padj float64 0 1	coloc_best_susie_pp4 float64 0 1 ⌀	coloc_best_susie_gwas stringclasses 50 values	coloc_abf_best_pp4 float64 0 1 ⌀	coloc_abf_best_gwas stringclasses 50 values	n_coloc_sources int64 0 6	n_ancestry_gwas int64 0 4	coloc_cross_ancestry_replicated bool 2 classes	coloc_susie_conf_tier stringclasses 4 values	coloc_tier12_pass bool 2 classes	coloc_tier12_union bool 2 classes	twas_z float64 -6 4.25 ⌀	twas_pval float64 0 0.98 ⌀	convergence_rank float64 1 26.5k ⌀	convergence_score float64 0.05 1 ⌀	convergence_tier stringclasses 3 values	concordance_state stringclasses 5 values	essentiality_chronos float64 -4.12 0.68 ⌀	is_essential bool 2 classes	spatial_is_svg bool 2 classes	spatial_morans_i float64 -0.03 0.8 ⌀	spatial_consensus_direction stringclasses 1 value	zonation_class stringclasses 2 values	ferroptosis_class stringclasses 3 values	dgidb_druggable bool 2 classes	opentargets_drug bool 1 class	max_phase_masld float64 1 4 ⌀	drug_dev_status stringclasses 7 values	pharos_tdl stringclasses 4 values	dominant_program_for_gene stringclasses 6 values	dominant_program_logFC float64 -2.98 5.16	layers_active int64 0 6	is_conserved bool 2 classes
5S_rRNA	ENSG00000285776	rRNA_pseudogene	null	0.029082	0.836362	0.293698	0.016512	0.438327	false	0.25	0.989499	1	false	-0.000071	-0.072466	Concordant	0.537665	null	null	null	null	0	0	false	null	false	false	null	null	null	null	null	null	null	false	false	null	null	null	null	false	false	null	undetermined	null	Skeletal-muscle	0.462867	0	false
5_8S_rRNA	ENSG00000277739	rRNA	null	0.131445	0.532289	0.813375	0.056143	0.325443	false	0.25	0.777548	1	false	0.026168	0.017057	Concordant	0.894614	null	null	null	null	0	0	false	null	false	false	null	null	null	null	null	null	null	false	false	null	null	null	null	false	false	null	undetermined	null	Unresolved	0.831104	0	false
7SK	ENSG00000274303	misc_RNA	null	-0.092177	0.206419	-1.526041	-0.070215	0.115377	false	0.25	0.99543	1	false	0.016577	-0.081617	Concordant	0.431793	null	null	null	null	0	0	false	null	false	false	null	null	11,984	0.384725	4_Weak	Concordant-down	null	false	false	null	null	null	null	false	false	null	undetermined	null	Noncoding	0.56706	0	false
A1BG	ENSG00000121410	protein_coding	ENSMUSG00000022347	0.085402	0.136782	1.766635	0.070246	0.074334	false	0.25	0.999653	1	false	0.09295	0.13416	Concordant	0.733458	0.012525	MVP_Platelet_AFR	0.012525	MVP_Platelet_AFR	0	0	false	none	false	false	null	null	15,397	0.05	4_Weak	Insufficient-evidence	0.023009	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Unresolved	0.555846	3	false
A1BG-AS1	ENSG00000268895	lncRNA	null	0.205488	0.005373	3.125616	0.171982	0.004219	false	0.25	0.750726	1	false	-0.053499	0.168986	Concordant	0.176921	0.037871	MVP_AST_EUR	0.037871	MVP_AST_EUR	0	0	false	none	false	false	null	null	14,420	0.146533	4_Weak	Concordant-up	null	false	false	null	null	null	null	false	false	null	undetermined	null	Hepatocyte-Metabolic	-0.325707	1	false
A1CF	ENSG00000148584	protein_coding	ENSMUSG00000052595	-0.292628	0	-9.548127	-0.286453	0	false	0.25	0.082312	0.664215	false	-0.198745	-0.190703	Concordant	0.979912	0.026572	MVP_Platelet_EUR	0.026572	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	1,124	1	4_Weak	Concordant-down	-0.031611	false	false	null	single_cohort_only	null	null	false	false	null	masld_preclinical	Tbio	Hepatocyte-Metabolic	0.312975	3	true
A2M	ENSG00000175899	protein_coding	null	-0.103102	0.385459	-1.090328	-0.063144	0.224978	false	0.25	0.939758	1	false	-0.236935	-0.059669	Concordant	0.60479	0.048655	MVP_Albumin_EUR	0.048655	MVP_Albumin_EUR	0	0	false	none	false	false	null	null	238	1	4_Weak	Concordant-up	0.000928	false	true	0.124958	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Unresolved	-0.91951	3	false
A2M-AS1	ENSG00000245105	lncRNA	null	0.044419	0.450916	0.961541	0.035257	0.233611	false	0.25	0.999995	1	false	-0.077851	-0.018487	Concordant	0.785638	0.894628	MVP_ALT_EUR	0.822725	MVP_ALT_EUR	0	0	false	high	true	true	null	null	6,292	0.999602	1_Genetic_validated	Concordant-up	null	false	false	null	null	null	null	false	false	null	undetermined	null	Fibrotic-ECM	0.247849	2	false
A3GALT2	ENSG00000184389	protein_coding	null	0.224677	0.073581	2.088343	0.147448	0.065134	false	0.25	0.593016	1	false	0.192085	0.048496	Concordant	0.135131	0.011385	MVP_Albumin_EUR	0.011385	MVP_Albumin_EUR	0	0	false	none	false	false	null	null	15,398	0.05	4_Weak	Insufficient-evidence	-0.095266	false	false	null	null	null	null	false	false	null	discovery	Tdark	Hepatocyte-Metabolic	-0.480166	2	false
A4GALT	ENSG00000128274	protein_coding	ENSMUSG00000047878	0.006631	0.934843	0.121165	0.004879	0.493994	false	0.25	0.999997	1	false	-0.256578	-0.003118	Concordant	0.086754	0.994293	MVP_Platelet_EUR	0.401935	BBJ_GGT	0	0	false	high	false	false	null	null	15,399	0.05	4_Weak	Insufficient-evidence	-0.061762	false	false	null	null	null	null	false	false	null	masld_preclinical	Tbio	Noncoding	-0.536378	4	false
A4GNT	ENSG00000118017	protein_coding	ENSMUSG00000037953	0.087851	0.645213	0.614976	0.040222	0.364684	false	0.25	0.880796	1	false	-0.039435	-0.016822	Concordant	0.828388	0.047303	UKBB_GGT	0.047303	UKBB_GGT	0	0	false	none	false	false	null	null	8,987	0.941714	4_Weak	Concordant-up	0.035429	false	false	null	null	null	null	false	false	null	discovery	Tbio	Fibrotic-ECM	1.183828	2	false
AACS	ENSG00000081760	protein_coding	ENSMUSG00000029482	0.376674	0	6.980764	0.358992	0	false	0.25	0.009562	0.116734	false	0.229433	0.325983	Concordant	0.579509	0.025886	MVP_Albumin_AFR	0.025886	MVP_Albumin_AFR	0	0	false	none	false	false	null	null	952	1	4_Weak	Concordant-up	0.04272	false	false	0.015707	single_cohort_only	null	null	false	false	null	discovery	Tbio	Hepatocyte-Metabolic	-0.370747	2	false
AADAC	ENSG00000114771	protein_coding	ENSMUSG00000027761	-0.013454	0.829783	-0.304582	-0.010496	0.43698	false	0.25	1	1	false	0.168248	-0.003543	Concordant	0.089299	0.001912	UKBB_AST	0.686151	PanUKBB_CSA_GGT	1	1	false	none	false	true	-0.867401	0.385722	9,911	0.816058	1_Genetic_validated	Concordant-down	0.116441	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tchem	Unresolved	-0.483522	3	false
AADACP1	ENSG00000291076	lncRNA	null	-0.328385	0.000003	-5.077701	-0.300979	0.000003	false	0.25	0.112918	0.84713	false	-0.142527	-0.261025	Concordant	0.530625	null	null	null	null	0	0	false	null	false	false	null	null	6,688	0.999112	4_Weak	Concordant-down	null	false	false	null	null	null	null	false	false	null	undetermined	null	Noncoding	0.501456	0	false
AADAT	ENSG00000109576	protein_coding	ENSMUSG00000057228	-0.325623	0	-9.803346	-0.318609	0	false	0.25	0.011525	0.136594	false	-0.170992	-0.250885	Concordant	0.444736	0.000476	MVP_Platelet_EUR	0.093808	MVP_ALT_EUR	0	0	false	none	false	false	null	null	528	1	4_Weak	Concordant-down	-0.026456	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tchem	Fibrotic-ECM	-0.322124	4	true
AAGAB	ENSG00000103591	protein_coding	ENSMUSG00000037257	0.249215	0	11.026631	0.245673	0	false	0.25	0.513842	1	false	0.294681	0.206415	Concordant	0.252946	0.011609	MVP_Albumin_EUR	0.13373	PanUKBB_CSA_GGT	0	0	false	none	false	false	null	null	1,125	1	4_Weak	Concordant-up	-0.003221	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Inflammatory-EMT	0.191073	3	false
AAK1	ENSG00000115977	protein_coding	ENSMUSG00000057230	0.091966	0.001073	3.628887	0.087226	0.000498	false	0.25	1	1	false	-0.019751	0.06704	Concordant	0.153088	0.016359	MVP_Platelet_EUR	0.016359	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	1,126	1	4_Weak	Concordant-up	-0.184443	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tchem	Hepatocyte-Metabolic	-0.317038	3	false
AAMDC	ENSG00000087884	protein_coding	ENSMUSG00000035642	-0.034175	0.311729	-1.250945	-0.029913	0.167435	false	0.25	1	1	false	0.062012	-0.100074	Concordant	0.018084	0.001252	MVP_Platelet_EUR	0.106601	2021_34957434_PDFF_EUR	0	0	false	none	false	false	0.793228	0.427645	15,400	0.05	4_Weak	Insufficient-evidence	-0.018133	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Inflammatory-EMT	-0.086448	4	true
AAMP	ENSG00000127837	protein_coding	ENSMUSG00000006299	-0.017675	0.584979	-0.719764	-0.014936	0.320871	false	0.25	1	1	false	0.049019	-0.017661	Concordant	0.31439	0.041252	MVP_Platelet_EUR	0.041252	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	5,876	0.999851	4_Weak	Concordant-down	-0.83265	true	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Unresolved	0.177184	4	false
AAR2	ENSG00000131043	protein_coding	ENSMUSG00000027628	0.066556	0.000548	3.820585	0.064704	0.000255	false	0.25	1	1	false	0.142866	0.035094	Concordant	0.029429	0.026475	MVP_Platelet_EUR	0.026475	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	15,401	0.05	4_Weak	Insufficient-evidence	-0.00712	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Noncoding	-0.111657	3	false
AARS1	ENSG00000090861	protein_coding	ENSMUSG00000031960	-0.008622	0.7899	-0.372624	-0.007134	0.440168	false	0.25	1	1	false	-0.036559	0.02946	Concordant	0.412488	0.001553	MVP_ALT_EUR	0.12469	MVP_Cirrhosis_AFR	0	0	false	none	false	false	null	null	12,367	0.334314	4_Weak	Concordant-down	-2.378092	true	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	null	Unresolved	0.115095	3	false
AARS2	ENSG00000124608	protein_coding	ENSMUSG00000023938	0.012711	0.74941	0.441927	0.010518	0.404798	false	0.25	1	1	false	-0.041315	0.025971	Concordant	0.330087	0.166601	MVP_Platelet_EUR	0.166601	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	15,402	0.05	4_Weak	Insufficient-evidence	-0.643057	true	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Unresolved	0.458026	2	false
AARSD1	ENSG00000266967	protein_coding	ENSMUSG00000075528	0.128116	0.134012	1.777798	0.093939	0.083665	false	0.25	0.954427	1	false	0.290009	0.000423	Concordant	0.049211	0.045357	MVP_Platelet_EUR	0.045357	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	15,403	0.05	4_Weak	Insufficient-evidence	-0.267601	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tdark	Unresolved	0.552924	3	false
AASDH	ENSG00000157426	protein_coding	ENSMUSG00000055923	-0.001355	0.96376	-0.068219	-0.001103	0.55375	false	0.25	1	1	false	0.010534	-0.001398	Concordant	0.905068	0.00376	MVP_Platelet_EUR	0.065737	2020_32298765_NAFLD_EUR	0	0	false	none	false	false	1.197304	0.231188	15,404	0.05	4_Weak	Insufficient-evidence	-0.037469	false	false	null	null	null	null	false	false	null	discovery	Tbio	Noncoding	0.2089	3	false
AASDHPPT	ENSG00000149313	protein_coding	ENSMUSG00000025894	-0.019117	0.576032	-0.735987	-0.016152	0.31284	false	0.25	1	1	false	0.091138	-0.020848	Concordant	0.049115	0.735954	FinnGen_NAFLD	0.735954	FinnGen_NAFLD	0	0	false	none	false	true	0.278906	0.780317	11,048	0.575246	1_Genetic_validated	Concordant-up	-0.344293	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Unresolved	-0.404973	4	false
AASS	ENSG00000008311	protein_coding	ENSMUSG00000029695	-0.625801	0	-11.836329	-0.613687	0	true	0.25	0	0	true	-0.564033	-0.510008	Concordant	0.828388	0.04236	MVP_Cirrhosis_AMR	0.04236	MVP_Cirrhosis_AMR	0	0	false	none	false	false	null	null	70	1	4_Weak	Concordant-down	-0.00659	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Inflammatory-EMT	-0.457732	5	true
AATBC	ENSG00000215458	lncRNA	null	0.625509	0	7.807972	0.596895	0	true	0.25	0.000002	0.000057	true	0.629459	0.538277	Concordant	0.702001	0.025718	UKBB_ALT	0.025718	UKBB_ALT	0	0	false	none	false	false	null	null	6,693	0.999093	4_Weak	Concordant-up	null	false	false	null	null	null	null	false	false	null	undetermined	null	Unresolved	0.70056	1	false
AATK	ENSG00000181409	protein_coding	ENSMUSG00000025375	0.064643	0.533875	0.810408	0.04205	0.286572	false	0.25	0.989856	1	false	-0.348905	0.049474	Concordant	0.016613	0.208413	MVP_ChronLiver_EUR	0.208413	MVP_ChronLiver_EUR	0	0	false	none	false	false	null	null	15,405	0.05	4_Weak	Insufficient-evidence	-0.0889	false	false	null	null	null	null	false	false	null	discovery	Tbio	Hepatocyte-Metabolic	-0.624582	3	false
ABALON	ENSG00000281376	lncRNA	null	0.122735	0.354348	1.15518	0.071216	0.217717	false	0.25	0.884574	1	false	-0.006827	0.037392	Concordant	0.755249	null	null	null	null	0	0	false	null	false	false	null	null	15,406	0.05	4_Weak	Insufficient-evidence	null	false	false	null	null	null	null	false	false	null	undetermined	null	Skeletal-muscle	0.507093	0	false
ABAT	ENSG00000183044	protein_coding	ENSMUSG00000057880	-0.34932	0	-11.024253	-0.343096	0	true	0.25	0.000891	0.015609	true	-0.207427	-0.234349	Concordant	0.809317	0.001727	BBJ_ALT	0.304369	PanUKBB_AFR_ALT	0	0	false	none	false	false	null	null	1,127	1	4_Weak	Concordant-down	-0.069873	false	false	null	single_cohort_only	null	null	true	false	null	masld_clinical	Tclin	Hepatocyte-Metabolic	0.3149	5	true
ABCA1	ENSG00000165029	protein_coding	ENSMUSG00000015243	-0.34954	0	-9.476975	-0.341094	0	false	0.25	0.003549	0.051009	false	-0.380344	-0.231797	Concordant	0.231536	0.002771	UKBB_AST	0.399993	MVP_ChronLiver_EUR	0	0	false	none	false	false	null	null	5,151	0.999981	4_Weak	Concordant-down	-0.030809	false	false	null	single_cohort_only	null	null	true	false	null	masld_preclinical	Tclin	Unresolved	-0.251283	4	false
ABCA10	ENSG00000154263	protein_coding	null	-0.273702	0.000055	-4.417979	-0.246425	0.000046	false	0.25	0.35106	1	false	-0.224459	-0.324916	Concordant	0.57812	0.000323	MVP_ALT_EUR	0.339165	MVP_Platelet_EUR	0	0	false	none	false	false	0.573876	0.566052	6,288	0.999604	4_Weak	Concordant-down	0.086535	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tdark	Hepatocyte-Metabolic	-0.401923	3	false
ABCA11P	ENSG00000251595	transcribed_processed_pseudogene	null	-0.140365	0.085052	-2.015759	-0.106273	0.05507	false	0.25	0.988258	1	false	0.066415	-0.209126	Concordant	0.066527	0.000404	MVP_Platelet_EUR	0.066144	MVP_ALT_EUR	0	0	false	none	false	false	null	null	15,407	0.05	4_Weak	Insufficient-evidence	null	false	false	null	null	null	null	false	false	null	discovery	Tdark	Noncoding	0.498033	0	false
ABCA13	ENSG00000179869	protein_coding	null	-0.712359	0	-6.832467	-0.666052	0	true	0.25	0.000005	0.000162	true	-0.578178	-0.698462	Concordant	0.702763	0.030577	MVP_ALT_EUR	0.030577	MVP_ALT_EUR	0	0	false	none	false	false	null	null	6,096	0.999745	4_Weak	Concordant-down	-0.028774	false	false	null	null	null	null	false	false	null	discovery	Tbio	Inflammatory-EMT	-0.783477	2	false
ABCA2	ENSG00000107331	protein_coding	ENSMUSG00000026944	0.245403	0.000002	5.217077	0.229272	0.000001	false	0.25	0.538912	1	false	-0.007787	0.359557	Concordant	0.0001	0.094365	MVP_AST_EUR	0.094365	MVP_AST_EUR	0	0	false	none	false	false	null	null	1,128	1	4_Weak	Concordant-up	-0.02861	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Unresolved	0.587842	5	false
ABCA3	ENSG00000167972	protein_coding	ENSMUSG00000024130	0.245437	0	6.035146	0.233524	0	false	0.25	0.544653	1	false	0.035017	0.219749	Concordant	0.109339	0.03404	MVP_Albumin_EUR	0.03404	MVP_Albumin_EUR	0	0	false	none	false	false	null	null	1,129	1	4_Weak	Concordant-up	0.005361	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Noncoding	-0.361043	3	false
ABCA4	ENSG00000198691	protein_coding	ENSMUSG00000028125	0.013826	0.856914	0.257738	0.010254	0.449167	false	0.25	0.999994	1	false	-0.192502	0.073732	Concordant	0.048609	0.030438	MVP_AST_EUR	0.030438	MVP_AST_EUR	0	0	false	none	false	false	null	null	15,408	0.05	4_Weak	Insufficient-evidence	-0.19877	false	false	null	null	null	null	true	false	null	drugged_other_indication	Tbio	Hepatocyte-Metabolic	-0.298164	2	false
ABCA5	ENSG00000154265	protein_coding	ENSMUSG00000018800	-0.14064	0.00016	-4.149998	-0.130994	0.000077	false	0.25	0.99935	1	false	0.011215	-0.148663	Concordant	0.0699	0.000424	MVP_AST_EUR	0.255873	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	1,130	1	4_Weak	Concordant-down	-0.026417	false	false	null	single_cohort_only	null	null	true	false	null	discovery	Tbio	Noncoding	0.334305	5	false
ABCA6	ENSG00000154262	protein_coding	ENSMUSG00000044749	-0.324238	0	-10.577753	-0.318263	0	false	0.25	0.007824	0.09881	false	-0.284364	-0.273935	Concordant	0.968877	0.021631	MVP_Albumin_EUR	0.021631	MVP_Albumin_EUR	0	0	false	none	false	false	null	null	1,131	1	4_Weak	Concordant-down	0.061314	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Noncoding	0.250281	4	true
ABCA7	ENSG00000064687	protein_coding	ENSMUSG00000035722	0.493557	0	8.568642	0.476436	0	true	0.25	0.000013	0.00037	true	0.241915	0.480927	Concordant	0.050636	0.012528	MVP_Platelet_EUR	0.012528	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	1,101	1	4_Weak	Concordant-up	0.045591	false	false	0.00259	single_cohort_only	null	null	false	false	null	discovery	Tbio	Hepatocyte-Metabolic	-0.638337	5	false
ABCA8	ENSG00000141338	protein_coding	ENSMUSG00000020620	-0.279923	0	-7.814274	-0.2713	0	false	0.25	0.201888	1	false	-0.291665	-0.179989	Concordant	0.370208	0.932111	MVP_Albumin_EUR	0.195877	MVP_Albumin_AFR	0	0	false	high	false	false	null	null	976	1	4_Weak	Concordant-down	-0.00543	false	false	0.013229	single_cohort_only	null	null	false	false	null	discovery	Tbio	Inflammatory-EMT	-0.249671	5	false
ABCA9	ENSG00000154258	protein_coding	ENSMUSG00000041797	-0.21359	0.00004	-4.495389	-0.196056	0.000025	false	0.25	0.778146	1	false	-0.214604	-0.19172	Concordant	0.956444	0.019486	2023_36280732_NAFLD_deCode_EUR	0.019486	2023_36280732_NAFLD_deCode_EUR	0	0	false	none	false	false	null	null	10,642	0.669869	4_Weak	Concordant-down	0.093729	false	false	null	null	null	null	false	false	null	discovery	Tbio	Noncoding	0.350599	4	false
ABCB1	ENSG00000085563	protein_coding	null	0.186516	0.000003	5.114763	0.175691	0.000001	false	0.25	0.958966	1	false	0.098779	0.266728	Concordant	0.062376	0.044866	MVP_ALT_EAS	0.044866	MVP_ALT_EAS	0	0	false	none	false	false	null	null	1,132	1	4_Weak	Concordant-up	-0.07427	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tchem	Unresolved	-0.449756	3	false
ABCB10	ENSG00000135776	protein_coding	ENSMUSG00000031974	0.041721	0.167102	1.652437	0.037772	0.090758	false	0.25	1	1	false	0.135516	0.0705	Concordant	0.411292	0.025812	MVP_ALT_EAS	0.025812	MVP_ALT_EAS	0	0	false	none	false	false	null	null	15,409	0.05	4_Weak	Insufficient-evidence	-0.215912	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Unresolved	-0.231875	3	false
ABCB11	ENSG00000073734	protein_coding	ENSMUSG00000027048	-0.525718	0	-8.365306	-0.506169	0	true	0.25	0.000006	0.000197	true	-0.596038	-0.296739	Concordant	0.063274	0.189104	UKBB_ALT	0.189104	UKBB_ALT	0	0	false	none	false	false	null	null	5,877	0.999851	4_Weak	Concordant-down	-0.085329	false	false	null	single_cohort_only	null	null	true	false	null	masld_preclinical	Tchem	Hepatocyte-Metabolic	0.300305	5	true
ABCB4	ENSG00000005471	protein_coding	ENSMUSG00000042476	0.360595	0	8.411542	0.349296	0	false	0.25	0.005026	0.068165	false	0.429184	0.371657	Concordant	0.799609	0.066947	MVP_ALT_AFR	0.066947	MVP_ALT_AFR	0	0	false	none	false	false	null	null	4,168	1	4_Weak	Concordant-up	-0.008298	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Inflammatory-EMT	0.380002	3	true
ABCB6	ENSG00000115657	protein_coding	ENSMUSG00000026198	0.014866	0.823111	0.315616	0.011433	0.432	false	0.25	1	1	false	0.154581	-0.029375	Concordant	0.188146	0.030823	MVP_ALT_EUR	0.030823	MVP_ALT_EUR	0	0	false	none	false	false	null	null	15,410	0.05	4_Weak	Insufficient-evidence	0.02814	false	false	null	single_cohort_only	null	null	false	false	null	masld_preclinical	Tbio	Unresolved	0.350158	3	false
ABCB7	ENSG00000131269	protein_coding	ENSMUSG00000031333	-0.084849	0.000021	-4.649094	-0.08244	0.000008	false	0.25	1	1	false	-0.035668	-0.054757	Concordant	0.744177	null	null	null	null	0	0	false	null	false	false	null	null	7,390	0.996179	4_Weak	Concordant-down	-1.024476	true	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Unresolved	-0.193891	2	false
ABCB8	ENSG00000197150	protein_coding	ENSMUSG00000028973	0.230148	0	6.769421	0.221644	0	false	0.25	0.720282	1	false	0.120844	0.290298	Concordant	0.039313	0.032566	MVP_Albumin_EUR	0.032566	MVP_Albumin_EUR	0	0	false	none	false	false	null	null	5,940	0.999824	4_Weak	Concordant-up	0.04492	false	false	0.027565	single_cohort_only	null	null	false	false	null	discovery	Tbio	Unresolved	0.444738	3	false
ABCB9	ENSG00000150967	protein_coding	ENSMUSG00000029408	0.040501	0.562326	0.760377	0.030626	0.290968	false	0.25	0.999955	1	false	-0.231181	0.069838	Concordant	0.010382	0.586539	UKBB_ALT	0.365776	BBJ_GGT	0	0	false	suggestive	true	true	0.415546	0.677742	7,651	0.993534	1_Genetic_validated	Concordant-up	-0.022468	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Hepatocyte-Metabolic	-0.421986	4	false
ABCC1	ENSG00000103222	protein_coding	ENSMUSG00000023088	0.372661	0.000018	4.675602	0.332599	0.000023	false	0.25	0.062093	0.535907	false	-0.00764	0.289735	Concordant	0.075824	0.054339	MVP_ALT_EUR	0.156798	MVP_AST_EUR	0	0	false	none	false	false	null	null	5,127	0.999983	4_Weak	Concordant-up	0.049552	false	false	null	single_cohort_only	null	null	true	false	null	masld_preclinical	Tchem	Fibrotic-ECM	0.467292	5	false
ABCC10	ENSG00000124574	protein_coding	ENSMUSG00000032842	0.172099	0.000617	3.786939	0.155204	0.000372	false	0.25	0.956567	1	false	0.069837	0.163581	Concordant	0.221392	0.132595	MVP_Platelet_AFR	0.132595	MVP_Platelet_AFR	0	0	false	none	false	false	null	null	5,883	0.999849	4_Weak	Concordant-up	-0.155446	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Unresolved	0.620212	3	false
ABCC11	ENSG00000121270	protein_coding	null	-0.276205	0.000003	-5.074058	-0.255522	0.000002	false	0.25	0.315179	1	false	-0.253075	-0.128324	Concordant	0.62544	0.528816	MVP_Platelet_EUR	0.528816	MVP_Platelet_EUR	0	0	false	none	false	false	-1.316815	0.187901	1,133	1	4_Weak	Concordant-down	0.082797	false	false	null	null	null	null	false	false	null	discovery	Tbio	Fibrotic-ECM	-0.267952	3	false
ABCC12	ENSG00000140798	protein_coding	ENSMUSG00000036872	-0.064652	0.732407	-0.470834	-0.030121	0.398761	false	0.25	0.922371	1	false	-0.037526	-0.042806	Concordant	0.99509	0.022987	MVP_Platelet_AFR	0.022987	MVP_Platelet_AFR	0	0	false	none	false	false	null	null	15,411	0.05	4_Weak	Insufficient-evidence	0.064748	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Skeletal-muscle	1.434392	3	false
ABCC13	ENSG00000291052	lncRNA	null	-0.450185	0.027944	-2.518026	-0.257736	0.053597	false	0.25	0.131629	0.940284	false	-0.219662	-0.314105	Concordant	0.701339	0.525964	MVP_AST_EAS	0.525964	MVP_AST_EAS	0	0	false	none	false	true	null	null	15,412	0.05	4_Weak	Insufficient-evidence	null	false	false	null	null	null	null	false	false	null	undetermined	null	Skeletal-muscle	1.771654	2	false
ABCC2	ENSG00000023839	protein_coding	ENSMUSG00000025194	-0.178748	0	-6.180583	-0.171828	0	false	0.25	0.993025	1	false	-0.06233	-0.122665	Concordant	0.508736	0.338889	BBJ_GGT	0.338889	BBJ_GGT	0	0	false	none	false	false	null	null	6,055	0.999769	4_Weak	Concordant-down	-0.015512	false	false	null	single_cohort_only	Pericentral	null	true	false	null	masld_preclinical	Tchem	Noncoding	0.226876	4	false
ABCC3	ENSG00000108846	protein_coding	ENSMUSG00000020865	0.070609	0.082731	2.030147	0.062711	0.04331	false	0.25	1	1	false	0.017751	0.099888	Concordant	0.381933	0.000044	MVP_Platelet_EUR	0.099584	MVP_Platelet_EAS	0	0	false	none	false	false	null	null	15,413	0.05	4_Weak	Insufficient-evidence	-0.052142	false	false	null	single_cohort_only	null	null	true	false	null	masld_preclinical	Tbio	Unresolved	0.454815	4	false
ABCC4	ENSG00000125257	protein_coding	ENSMUSG00000032849	0.633135	0	10.202703	0.61643	0	true	0.25	0	0	true	0.426808	0.575183	Concordant	0.515423	0.00115	MVP_Platelet_EUR	0.167654	PanUKBB_AFR_ALT	0	0	false	none	false	false	null	null	1,134	1	4_Weak	Concordant-up	0.181608	false	false	null	null	null	null	true	false	null	drugged_other_indication	Tchem	Unresolved	-0.626905	6	true
ABCC5	ENSG00000114770	protein_coding	ENSMUSG00000022822	0.325986	0	8.993015	0.317622	0	false	0.25	0.01818	0.19891	false	0.113665	0.305364	Concordant	0.024813	0.079254	UKBB_AST	0.058783	MVP_Albumin_EAS	0	0	false	none	false	false	null	null	1,135	1	4_Weak	Concordant-up	0.021972	false	false	null	single_cohort_only	null	null	true	false	null	masld_preclinical	Tchem	Hepatocyte-Metabolic	-0.430276	5	true
ABCC6	ENSG00000275331	protein_coding	ENSMUSG00000030834	0.144971	0.047321	2.292512	0.115237	0.03064	false	0.25	0.916111	1	false	-0.069985	-0.053502	Concordant	0.984252	0.036037	MVP_AST_AFR	0.036037	MVP_AST_AFR	0	0	false	none	false	false	null	null	15,414	0.05	4_Weak	Insufficient-evidence	null	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Unresolved	0.433032	4	false
ABCC6P1	ENSG00000291057	lncRNA	null	-0.088773	0.071121	-2.104969	-0.076475	0.038152	false	0.25	0.999929	1	false	0.037736	-0.072515	Concordant	0.390944	0.009641	MVP_Platelet_EUR	0.009641	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	5,618	0.999925	4_Weak	Concordant-down	null	false	false	null	null	null	null	false	false	null	undetermined	null	Noncoding	0.405364	0	false
ABCC6P2	ENSG00000290943	lncRNA	null	0.084886	0.331107	1.207259	0.059889	0.183434	false	0.25	0.990456	1	false	0.059861	0.015386	Concordant	0.779208	null	null	null	null	0	0	false	null	false	false	null	null	6,650	0.999187	4_Weak	Concordant-down	null	false	false	null	null	null	null	false	false	null	undetermined	null	Fibrotic-ECM	-0.454723	0	false
ABCC8	ENSG00000006071	protein_coding	null	0.308687	0.093337	1.969152	0.165238	0.105158	false	0.25	0.354304	1	false	-0.007382	0.026664	Concordant	0.782097	0.031697	MVP_Platelet_AFR	0.031697	MVP_Platelet_AFR	0	0	false	none	false	false	null	null	14,254	0.153234	4_Weak	Concordant-up	0.063939	false	false	null	single_cohort_only	null	null	true	false	null	masld_clinical	Tclin	Skeletal-muscle	2.094125	2	false
ABCC9	ENSG00000069431	protein_coding	ENSMUSG00000030249	-0.251403	0	-6.705517	-0.24146	0	false	0.25	0.485083	1	false	-0.199422	-0.121551	Concordant	0.576317	0.000046	UKBB_ALT	0.047292	MVP_Albumin_AMR	0	0	false	none	false	false	0.851554	0.394462	367	1	4_Weak	Concordant-down	-0.04641	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tclin	Hepatocyte-Metabolic	0.427144	4	false
ABCD1	ENSG00000101986	protein_coding	ENSMUSG00000031378	0.108687	0.018819	2.674516	0.096195	0.010222	false	0.25	0.999734	1	false	-0.066834	0.217452	Concordant	0.001601	null	null	null	null	0	0	false	null	false	false	null	null	15,415	0.05	4_Weak	Insufficient-evidence	-0.091071	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Unresolved	0.580807	3	false
ABCD2	ENSG00000173208	protein_coding	ENSMUSG00000055782	0.474059	0	5.768623	0.437081	0	true	0.25	0.003267	0.047549	true	0.214779	0.268061	Concordant	0.825211	0.048947	MVP_Platelet_EUR	0.048947	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	1,136	1	4_Weak	Concordant-up	-0.045705	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Unresolved	-0.847394	4	true
ABCD3	ENSG00000117528	protein_coding	ENSMUSG00000028127	0.041417	0.240058	1.430363	0.036517	0.127561	false	0.25	1	1	false	0.210206	0.013363	Concordant	0.007661	0.057901	MVP_AST_EUR	0.057901	MVP_AST_EUR	0	0	false	none	false	false	null	null	15,416	0.05	4_Weak	Insufficient-evidence	-0.117426	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Unresolved	-0.336074	4	false
ABCD4	ENSG00000119688	protein_coding	ENSMUSG00000021240	-0.013674	0.675767	-0.564486	-0.011437	0.372424	false	0.25	1	1	false	-0.007057	-0.013018	Concordant	0.944322	0.002629	UKBB_GGT	0.185047	UKBB_AST	0	0	false	none	false	false	0.677507	0.498084	7,517	0.995008	4_Weak	Concordant-down	-0.050536	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Unresolved	0.345149	4	false
ABCE1	ENSG00000164163	protein_coding	ENSMUSG00000058355	-0.02322	0.55562	-0.771927	-0.019506	0.29537	false	0.25	1	1	false	0.09517	-0.034538	Concordant	0.035265	0.021133	MVP_Platelet_EUR	0.021133	MVP_Platelet_EUR	0	0	false	none	false	false	3.323392	0.000889	15,417	0.05	4_Weak	Insufficient-evidence	-1.816422	true	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Unresolved	-0.511728	3	false
ABCF2	ENSG00000033050	protein_coding	ENSMUSG00000028953	0.183329	0	5.738724	0.174965	0	false	0.25	0.981407	1	false	0.28206	0.092771	Concordant	0.033114	0.087158	MVP_ChronLiver_EAS	0.087158	MVP_ChronLiver_EAS	0	0	false	none	false	false	0.887828	0.374633	5,109	0.999984	4_Weak	Concordant-up	null	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Hepatocyte-Metabolic	-0.197	3	false
ABCF3	ENSG00000161204	protein_coding	ENSMUSG00000003234	0.058522	0.011969	2.845874	0.056054	0.006212	false	0.25	1	1	false	0.017592	0.075955	Concordant	0.299597	0.049627	UKBB_AST	0.068504	MVP_Albumin_EUR	0	0	false	none	false	false	null	null	15,064	0.053677	4_Weak	Insufficient-evidence	0.062924	false	false	0.015938	single_cohort_only	null	null	false	false	null	discovery	Tbio	Unresolved	0.294624	2	false
ABCG1	ENSG00000160179	protein_coding	ENSMUSG00000024030	-0.195217	0.00051	-3.840223	-0.174615	0.000339	false	0.25	0.859256	1	false	-0.454946	-0.10411	Concordant	0.014111	0.020365	2021_34957434_PDFF_EUR	0.020365	2021_34957434_PDFF_EUR	0	0	false	none	false	false	null	null	5,284	0.999972	4_Weak	Concordant-down	-0.016223	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Noncoding	-0.314112	3	false
ABCG2	ENSG00000118777	protein_coding	ENSMUSG00000029299	-0.346249	0	-7.460177	-0.332756	0	false	0.25	0.019202	0.207789	false	-0.189239	-0.29141	Concordant	0.477575	0.0098	BBJ_GGT	0.083951	2023_36280732_NAFLD_deCode_EUR	0	0	false	none	false	false	null	null	1,137	1	4_Weak	Concordant-down	0.074901	false	false	null	null	null	null	true	false	null	masld_preclinical	Tchem	Hepatocyte-Metabolic	0.41781	3	false
ABCG4	ENSG00000172350	protein_coding	null	0.486619	0.000014	4.732784	0.427758	0.000028	false	0.25	0.010808	0.12937	false	0.350143	0.44358	Concordant	0.816748	0.045136	MVP_Platelet_EAS	0.045136	MVP_Platelet_EAS	0	0	false	none	false	false	null	null	9,186	0.921824	4_Weak	Concordant-up	0.016336	false	false	null	single_cohort_only	null	null	true	false	null	discovery	Tbio	Skeletal-muscle	0.497602	3	false
ABCG5	ENSG00000138075	protein_coding	ENSMUSG00000040505	-0.064874	0.117264	-1.850247	-0.057099	0.061509	false	0.25	1	1	false	-0.062581	-0.054628	Concordant	0.988152	0.00014	MVP_Platelet_EUR	0.069037	2023_36280732_NAFLD_deCode_EUR	0	0	false	none	false	false	null	null	7,085	0.997967	4_Weak	Concordant-down	0.009259	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Unresolved	0.393506	3	false
ABCG8	ENSG00000143921	protein_coding	ENSMUSG00000024254	-0.077955	0.0357	-2.414957	-0.070882	0.018473	false	0.25	1	1	false	-0.090661	-0.024531	Concordant	0.60479	0.035905	UKBB_AST	0.052989	UKBB_GGT	0	0	false	none	false	false	null	null	4,220	0.999999	4_Weak	Concordant-down	0.017783	false	false	null	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Unresolved	0.268595	4	false
ABHD1	ENSG00000143994	protein_coding	ENSMUSG00000006638	0.140879	0.01868	2.677332	0.119281	0.011498	false	0.25	0.9808	1	false	0.302902	0.136527	Concordant	0.385348	0.002206	MVP_ChronLiver_AMR	0.202208	PanUKBB_CSA_GGT	0	0	false	none	false	false	3.567897	0.00036	1,138	1	4_Weak	Concordant-down	-0.006465	false	false	null	null	null	null	false	false	null	discovery	Tdark	Unresolved	0.635135	2	false
ABHD10	ENSG00000144827	protein_coding	ENSMUSG00000033157	-0.157614	0	-6.191327	-0.152057	0	false	0.25	0.999849	1	false	-0.04214	-0.146851	Concordant	0.09308	0.000414	MVP_Platelet_EUR	0.363153	MVP_Platelet_AMR	0	0	false	none	false	false	null	null	4,499	0.999998	4_Weak	Concordant-down	0.035665	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Unresolved	-0.276636	5	false
ABHD11	ENSG00000106077	protein_coding	ENSMUSG00000040532	0.077905	0.061323	2.174494	0.069248	0.032122	false	0.25	0.999999	1	false	0.096449	0.020479	Concordant	0.508006	0.069692	MVP_AST_EUR	0.069692	MVP_AST_EUR	0	0	false	none	false	false	null	null	15,418	0.05	4_Weak	Insufficient-evidence	-0.378871	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Unresolved	0.421049	3	false
ABHD12	ENSG00000100997	protein_coding	ENSMUSG00000032046	0.173976	0	6.938562	0.16872	0	false	0.25	0.998748	1	false	0.165735	0.151494	Concordant	0.950387	0.760545	UKBB_ALT	0.504953	UKBB_ALT	0	0	false	suggestive	true	true	2.450629	0.014261	86	1	1_Genetic_validated	Concordant-up	0.046331	false	false	0.019038	single_cohort_only	null	null	false	false	null	drugged_other_indication	Tchem	Inflammatory-EMT	0.130436	4	false
ABHD13	ENSG00000139826	protein_coding	ENSMUSG00000040396	-0.020237	0.609345	-0.676672	-0.01691	0.32553	false	0.25	1	1	false	0.059872	-0.023011	Concordant	0.345894	0.024813	MVP_Albumin_EUR	0.024813	MVP_Albumin_EUR	0	0	false	none	false	false	null	null	15,419	0.05	4_Weak	Insufficient-evidence	-0.186429	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tdark	Unresolved	-0.390335	4	false
ABHD14A	ENSG00000248487	protein_coding	ENSMUSG00000042210	-0.003314	0.957599	-0.079783	-0.002608	0.514897	false	0.25	1	1	false	0.238824	-0.049715	Concordant	0.004836	0.048945	MVP_AST_EUR	0.048945	MVP_AST_EUR	0	0	false	none	false	false	null	null	15,016	0.054186	4_Weak	Insufficient-evidence	-0.027578	false	false	0.01816	single_cohort_only	null	null	false	false	null	discovery	Tdark	Unresolved	0.25671	3	false
ABHD14B	ENSG00000114779	protein_coding	ENSMUSG00000042073	-0.083206	0.016344	-2.729453	-0.076736	0.008303	false	0.25	1	1	false	-0.001743	-0.029392	Concordant	0.736991	0.018144	MVP_AST_EUR	0.018144	MVP_AST_EUR	0	0	false	none	false	false	null	null	6,399	0.99949	4_Weak	Concordant-down	0.001872	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tdark	Hepatocyte-Metabolic	0.181312	4	true
ABHD15	ENSG00000168792	protein_coding	ENSMUSG00000000686	-0.195908	0	-8.13686	-0.191318	0	false	0.25	0.98754	1	false	-0.061239	-0.181814	Concordant	0.056527	0.701305	MVP_Platelet_AFR	0.701305	MVP_Platelet_AFR	0	0	true	none	false	false	null	null	1,139	1	4_Weak	Concordant-down	-0.19602	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tdark	Unresolved	0.307235	4	false
ABHD17A	ENSG00000129968	protein_coding	ENSMUSG00000003346	0.056796	0.265345	1.36271	0.047205	0.138587	false	0.25	0.999998	1	false	-0.075161	0.085139	Concordant	0.066483	0.011446	MVP_Platelet_EUR	0.011446	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	15,420	0.05	4_Weak	Insufficient-evidence	-0.249438	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Unresolved	0.602452	3	false
ABHD17AP1	ENSG00000198658	unprocessed_pseudogene	null	-0.019897	0.825936	-0.310987	-0.013913	0.430466	false	0.25	0.999843	1	false	0.001603	-0.032113	Concordant	0.838704	null	null	null	null	0	0	false	null	false	false	null	null	15,421	0.05	4_Weak	Insufficient-evidence	null	false	false	null	null	null	null	false	false	null	undetermined	null	Unresolved	0.276461	0	false
ABHD17AP5	ENSG00000263366	processed_pseudogene	null	0.218004	0.009385	2.933817	0.176081	0.00795	false	0.25	0.66656	1	false	0.134831	0.142219	Concordant	0.969279	null	null	null	null	0	0	false	null	false	false	null	null	12,742	0.277667	4_Weak	Concordant-up	null	false	false	null	null	null	null	false	false	null	undetermined	null	Skeletal-muscle	0.351484	0	false
ABHD17B	ENSG00000107362	protein_coding	ENSMUSG00000047368	-0.15317	0	-7.960156	-0.149955	0	false	0.25	1	1	false	-0.128451	-0.115434	Concordant	0.92077	0.011819	MVP_Platelet_EUR	0.011819	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	1,140	1	4_Weak	Concordant-down	0.031549	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Hepatocyte-Metabolic	0.190554	3	false
ABHD17C	ENSG00000136379	protein_coding	ENSMUSG00000038459	0.172807	0.000616	3.787581	0.155789	0.000372	false	0.25	0.954484	1	false	0.213927	0.090262	Concordant	0.507842	0.043894	MVP_Platelet_EUR	0.032531	MVP_ChronLiver_AFR	0	0	false	none	false	false	1.21357	0.224912	5,027	0.999987	4_Weak	Concordant-up	0.086653	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Fibrotic-ECM	0.235763	4	false
ABHD18	ENSG00000164074	protein_coding	ENSMUSG00000037818	-0.180672	0	-9.139934	-0.177458	0	false	0.25	0.999762	1	false	-0.131523	-0.14662	Concordant	0.842034	0.564737	MVP_Platelet_EUR	0.564737	MVP_Platelet_EUR	0	0	false	none	false	false	null	null	1,141	1	4_Weak	Concordant-down	0.074812	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tdark	Noncoding	0.219281	4	true
ABHD2	ENSG00000140526	protein_coding	ENSMUSG00000039202	-0.016222	0.730122	-0.474303	-0.013256	0.386961	false	0.25	1	1	false	0.08637	0.043257	Concordant	0.790751	0.001252	MVP_Platelet_AFR	0.076386	2021_34128465_PDFF_EUR	0	0	false	none	false	false	null	null	8,574	0.968787	4_Weak	Concordant-down	-0.030299	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Hepatocyte-Metabolic	0.264315	4	false
ABHD3	ENSG00000158201	protein_coding	ENSMUSG00000002475	-0.11071	0.000049	-4.445197	-0.105668	0.00002	false	0.25	1	1	false	0.01269	-0.156898	Concordant	0.013074	0.009263	MVP_Platelet_EUR	0.424325	UKBB_AST	0	0	false	none	false	false	null	null	10,729	0.6508	4_Weak	Concordant-down	-0.089626	false	false	null	null	null	null	false	false	null	discovery	Tbio	Unresolved	-0.207329	4	false
ABHD4	ENSG00000100439	protein_coding	ENSMUSG00000040997	0.138246	0.000003	5.046036	0.131817	0.000001	false	0.25	0.999975	1	false	0.115543	0.118058	Concordant	0.949296	0.019396	MVP_AST_EUR	0.019396	MVP_AST_EUR	0	0	false	none	false	false	-1.144784	0.252299	5,600	0.999928	4_Weak	Concordant-up	0.001598	false	false	-0.008055	single_cohort_only	null	null	false	false	null	discovery	Tbio	Inflammatory-EMT	0.170776	3	true
ABHD5	ENSG00000011198	protein_coding	ENSMUSG00000032540	0.037709	0.313205	1.247489	0.032697	0.1658	false	0.25	1	1	false	0.189115	0.043628	Concordant	0.103141	0.034537	MVP_Platelet_AFR	0.034537	MVP_Platelet_AFR	0	0	false	none	false	false	null	null	9,607	0.866937	4_Weak	Concordant-up	-0.069041	false	false	null	single_cohort_only	null	null	false	false	null	masld_preclinical	Tbio	Unresolved	-0.299194	3	false
ABHD6	ENSG00000163686	protein_coding	ENSMUSG00000025277	0.059638	0.043506	2.330219	0.055569	0.022757	false	0.25	1	1	false	0.210069	0.061579	Concordant	0.041707	0.135914	MVP_Platelet_AFR	0.135914	MVP_Platelet_AFR	0	0	false	none	false	false	null	null	8,203	0.982983	4_Weak	Concordant-down	0.007088	false	false	null	single_cohort_only	null	null	true	false	null	masld_preclinical	Tchem	Fibrotic-ECM	-0.205948	3	false
ABHD8	ENSG00000127220	protein_coding	ENSMUSG00000007950	0.015692	0.789704	0.373	0.012386	0.4151	false	0.25	1	1	false	-0.051508	0.137735	Concordant	0.052512	0.001285	UKBB_AST	0.056581	FinnGen_NAFLD	0	0	false	none	false	false	null	null	10,194	0.759433	4_Weak	Concordant-down	0.026822	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tdark	Unresolved	0.475441	3	false
ABI1	ENSG00000136754	protein_coding	ENSMUSG00000058835	0.054439	0.009498	2.929672	0.052521	0.005011	false	0.25	1	1	false	0.07121	0.037484	Concordant	0.586316	0.019719	MVP_ALT_EUR	0.019719	MVP_ALT_EUR	0	0	false	none	false	false	null	null	13,730	0.18589	4_Weak	Concordant-up	-0.083812	false	false	0.007232	single_cohort_only	null	null	true	false	null	drugged_other_indication	Tbio	Unresolved	-0.280504	4	false
ABI2	ENSG00000138443	protein_coding	ENSMUSG00000026782	-0.00646	0.844523	-0.279863	-0.005325	0.472158	false	0.25	1	1	false	-0.116272	-0.050632	Concordant	0.407924	0.022246	UKBB_AST	0.022246	UKBB_AST	0	0	false	none	false	false	null	null	12,339	0.337828	4_Weak	Insufficient-evidence	0.062085	false	true	0.050112	single_cohort_only	null	null	false	false	null	discovery	Tbio	Fibrotic-ECM	0.277369	3	false
ABI3	ENSG00000108798	protein_coding	ENSMUSG00000018381	0.056337	0.294412	1.290963	0.046174	0.153711	false	0.25	0.999995	1	false	-0.15687	0.073638	Concordant	0.040641	0.12085	MVP_NAFLD_EAS	0.12085	MVP_NAFLD_EAS	0	0	false	none	false	false	null	null	15,422	0.05	4_Weak	Insufficient-evidence	0.005776	false	false	null	single_cohort_only	null	null	false	false	null	discovery	Tbio	Noncoding	-0.391861	3	true
ABI3BP	ENSG00000154175	protein_coding	ENSMUSG00000035258	0.103229	0.159196	1.680726	0.079094	0.091594	false	0.25	0.991458	1	false	-0.215457	0.015324	Concordant	0.198195	0.010918	MVP_Albumin_EUR	0.084463	PanUKBB_CSA_GGT	0	0	false	none	false	false	null	null	9,460	0.888413	4_Weak	Concordant-up	0.064845	false	false	0.039534	single_cohort_only	null	null	false	false	null	discovery	Tbio	Fibrotic-ECM	0.703567	2	false

End of preview. Expand in Data Studio

MASLD Multi-Evidence Atlas — web data

Backing data for the MASLD atlas web portal (Hugging Face Static Space). A human-only metabolic-dysfunction-associated steatotic liver disease (MASLD) transcriptomic + multi-omic evidence atlas. Disease effects are framed in human tissue only; cross-ancestry genetics (EUR / AFR / EAS / AMR / SAS) is first-class. Mouse content is retained solely for the Cas13 perturbation-library design and is never used to make disease claims.

Generated: 2026-07-09. Column names in the parquet files are data (kept verbatim); UI labels never reproduce internal statistical shorthand.

Provenance (canonical sources + dates)

Layer	Source (project-relative)	Canonical date	Headline
Bulk RNA-seq DEG	`canonical_deg_results.csv` (pooled limma-voom-qw, C2 design)	2026-06-29	1,918 DEGs via the effect-size-aware interval-null FDR gate (`fdr < 0.05` at `lfc = 0.25`, McCarthy & Smyth 2009)
Multi-evidence atlas	`multi_evidence_atlas.csv`	2026-07-06	27,187 genes × 443 evidence columns
Convergence ranking	`convergence_evidence.csv` (46d)	2026-07-06	Tier-1 = 677 (evidence-weighted rank, not a posterior)
Genetics / COLOC	`susie_coloc/` (SuSiE + ABF, PolyFun EUR LD)	2026-07-06	50-GWAS / 5-ancestry portfolio; 473 SuSiE / 1,031 union effector genes (main Tier-1/2)
Single-cell	`Analysis/SingleCell/results_gpu_v2/`	2026	~1.23M cells; 16 cell types; pseudobulk + hepatocyte subtypes
Spatial	`Analysis/Spatial/results/`	2026	Visium + GeoMx + CosMx zonation, SVGs, zonation disruption
Molecular programs	`subtypes/` (NMF k=6, P1–P6) + Hotspot modules	2026	6 continuous program axes (not discrete subtypes); autocorrelation modules
Sex	`sex_v3/` (LVQW-fixed, C2)	2026-06-08	8 sex-dimorphic genes (7 male-biased / 1 female-biased)
Proteomics	DIA-MS + Olink	2026	plasma/tissue mRNA↔protein concordance
Drug repurposing	`drug_repurposing/` (LINCS/CGP + clinical)	2026	2 approved / 208 clinical / 1,504 preclinical target-linked
Network	`network/edge_annotation_atlas.parquet`	2026	filtered gene–gene multi-channel edges + nodes

Primary table — `atlas_core.parquet`

The client's main table (~42 columns), keyed by human_symbol. The dataset viewer above is configured to preview it. Column families:

Identity: human_symbol, ensembl_id, gene_biotype, mouse_ortholog.
Bulk DE (pooled C2 limma-voom-qw): bulk_logFC, bulk_padj, bulk_tstat, bulk_shrunk_logFC, bulk_lfsr, bulk_sig, is_deg (interval-null FDR gate), plus interval-null estimate columns and sex-stratified bulk_logFC_M/F, sex_class, sex_interaction_padj.
Genetics / COLOC: coloc_best_susie_pp4, coloc_best_susie_gwas, coloc_abf_best_pp4, coloc_abf_best_gwas, n_coloc_sources, n_ancestry_gwas, coloc_cross_ancestry_replicated, coloc_susie_conf_tier, twas_z, twas_pval.
Convergence: convergence_rank, convergence_score, convergence_tier, concordance_state.
Essentiality / spatial / zonation / ferroptosis: essentiality_chronos, is_essential, spatial_is_svg, spatial_morans_i, spatial_consensus_direction, zonation_class, ferroptosis_class.
Druggability / programs: dgidb_druggable, opentargets_drug, max_phase_masld, drug_dev_status, pharos_tdl, dominant_program_for_gene, dominant_program_logFC, layers_active, is_conserved.

The full 443-column atlas.parquet is retained as a bulk download artifact. Long-format gene_* / coloc_by_gwas / sc_* / spatial_* / program_gene_membership / sex_gene_classification parquets are sorted by symbol for WHERE symbol = ? gene-detail lookups.

How the web app consumes this

The portal is a static Next.js export on a Hugging Face Static Space. It fetches every file from this Dataset's resolve/main/ CDN via a whole-file GET (DATA_BASE = https://huggingface.co/datasets/jameshyojaelee/masld-atlas-data/resolve/main), registers the bytes into DuckDB-WASM, and queries client-side. HF's resolve endpoint serves Access-Control-Allow-Origin: *, so cross-origin whole-file reads work without a proxy. Parquet is tracked by Git LFS; small JSON is plain git.

Files

Loose parquet (LFS): atlas, atlas_core, coloc_by_gwas, gene_* detail tables, sc_*, spatial_zonation, program_gene_membership, sex_gene_classification, network_edges, network_nodes, (optional) sc_umap_downsampled.
Compact JSON: per-layer summaries + rankings + gene_symbols (fuse.js index).
network/portal_export_v2/: community + layer metadata + filter indexes (per-gene graph JSONs are intentionally excluded — the client reads network_edges.parquet instead).

Downloads last month: 432

MASLD Multi-Evidence Atlas — web data

Provenance (canonical sources + dates)

Primary table — atlas_core.parquet

How the web app consumes this

Files

Space using jameshyojaelee/masld-atlas-data 1

Primary table — `atlas_core.parquet`