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TCGA-AO-A0JB | TCGA-BRCA | 6,481,524,938,623,040,000 | 3,598,391,053,150,423,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Upper-central breast irregular heterogeneous enhancing mass with adjacent small enhancing foci or contiguous extension. | Irregular spiculated stellate breast mass with heterogeneous enhancement and small adjacent enhancing foci near superficial vessels. | Deep posterior irregular enhancing focus/small mass with adjacent nonmass enhancement extending along fibroglandular tissue; nearby additional enhancing foci. | Irregular noncircumscribed enhancing focus with internal heterogeneity and variable conspicuity across slices, giving a suspicious infiltrative appearance. | Irregular spiculated stellate breast mass with heterogeneous enhancement and small adjacent enhancing foci near superficial vessels. | B | TCGA-AO-A0JB | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-AO-A0JB-01Z-00-DX1.250FE098-345B-4981-9236-0519E1C9058E.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AO-A0JB/1.3.6.1.4.1.14519.5.2.1.9203.4002.576998191521675502525281307152/1.3.6.1.4.1.14519.5.2.1.9203.4002.108867266986411861894751497504",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AO-A0JB-01A__6715f318-34ad-40ec-8ea4-06d356dddb1f.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AO-A0JB__2a09e101-9e01-45ec-9b02-d806f4cd7469.pt | |||||
TCGA-AO-A0JB | TCGA-BRCA | 4,471,394,947,830,224,400 | 3,542,895,442,570,343,400 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Low-cellularity discohesive cells and thin linear cords infiltrate densely fibrotic stroma, with limited tubules and no solid nests. | Scirrhous infiltrative carcinoma with irregular angulated glands, cords, and small nests in abundant desmoplastic stroma near adipose edge. | Invasive nests, cords, and angulated tubules in collagenized desmoplastic stroma, extending through fibrous tissue into adipose with blood-filled spaces. | Predominantly solid-vaguely nested infiltrative carcinoma in desmoplastic stroma, traversing fibroadipose tissue with entrapped adipocytes and patchy lymphoid infiltrates. | Invasive nests, cords, and angulated tubules in collagenized desmoplastic stroma, extending through fibrous tissue into adipose with blood-filled spaces. | C | TCGA-AO-A0JB | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-AO-A0JB-01Z-00-DX1.250FE098-345B-4981-9236-0519E1C9058E.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AO-A0JB/1.3.6.1.4.1.14519.5.2.1.9203.4002.576998191521675502525281307152/1.3.6.1.4.1.14519.5.2.1.9203.4002.108867266986411861894751497504",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AO-A0JB-01A__6715f318-34ad-40ec-8ea4-06d356dddb1f.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AO-A0JB__2a09e101-9e01-45ec-9b02-d806f4cd7469.pt | |||||
TCGA-AO-A0JB | TCGA-BRCA | 6,464,119,359,609,760,000 | 6,718,125,695,957,294,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | LumB with high ESR1/PGR/FOXA1/GATA3, high ESR1 promoter methylation, mutation-panel wild type, copy-number neutral, low TMB. | Basal-like TP53/PTEN-mutant, PIK3CA/GATA3/MAP3K1/CDH1 wild-type, copy-number quiet, low-TMB, low-HRD, HR-proficient-like profile. | TP53 p.R213* truncation with otherwise copy-number-neutral, low-TMB genomically quiet LumB/normal-like discordant luminal-expression profile. | PIK3CA H1047R with TP53 L194R and NF1 splice-site loss; HER2-enriched transcriptome, high ERBB2, ESR1/BRCA1 promoter methylation. | TP53 p.R213* truncation with otherwise copy-number-neutral, low-TMB genomically quiet LumB/normal-like discordant luminal-expression profile. | C | TCGA-AO-A0JB | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-AO-A0JB-01Z-00-DX1.250FE098-345B-4981-9236-0519E1C9058E.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AO-A0JB/1.3.6.1.4.1.14519.5.2.1.9203.4002.576998191521675502525281307152/1.3.6.1.4.1.14519.5.2.1.9203.4002.108867266986411861894751497504",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AO-A0JB-01A__6715f318-34ad-40ec-8ea4-06d356dddb1f.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AO-A0JB__2a09e101-9e01-45ec-9b02-d806f4cd7469.pt | |||||
TCGA-AO-A0JB | TCGA-BRCA | 8,946,693,839,538,963,000 | 7,208,833,406,086,384,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Compact irregular mass matches invasive stromal-adipose infiltration; lymphoid-rich necrotic histology and basal-like TP53-altered biology distinguish this case. | Cohesive nested invasive carcinoma with desmoplasia paired to genomically quiet AKT1-driven luminal A biology. | Metaplastic keratinizing non-luminal carcinoma with squamous differentiation, stromal hyalinization/inflammation, and combined PI3K activation plus TP53 loss. | Infiltrative spiculated multifocal-appearing breast carcinoma with stromal adipose invasion and isolated TP53 loss on an otherwise quiet luminal program. | Infiltrative spiculated multifocal-appearing breast carcinoma with stromal adipose invasion and isolated TP53 loss on an otherwise quiet luminal program. | D | TCGA-AO-A0JB | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-AO-A0JB-01Z-00-DX1.250FE098-345B-4981-9236-0519E1C9058E.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AO-A0JB/1.3.6.1.4.1.14519.5.2.1.9203.4002.576998191521675502525281307152/1.3.6.1.4.1.14519.5.2.1.9203.4002.108867266986411861894751497504",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AO-A0JB-01A__6715f318-34ad-40ec-8ea4-06d356dddb1f.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AO-A0JB__2a09e101-9e01-45ec-9b02-d806f4cd7469.pt | |||||
TCGA-AO-A0JM | TCGA-BRCA | 5,511,846,645,320,374,000 | 502,773,002,361,197,700 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Small enhancing breast mass limited to sampled slices, with surrounding parenchymal distortion. | Large ROI-spanning asymmetric regional enhancement with patchy internal high-signal foci and irregular non-circumscribed configuration. | Right upper outer/anterior breast focal nonmass-like to irregular heterogeneous enhancement across adjacent slices near lateral soft tissues. | Irregular heterogeneous enhancing breast mass with adjacent linear branching enhancement and infiltrative extension into fibroglandular tissue. | Irregular heterogeneous enhancing breast mass with adjacent linear branching enhancement and infiltrative extension into fibroglandular tissue. | D | TCGA-AO-A0JM | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-AO-A0JM-01Z-00-DX1.94E75EFD-E5F5-4DF8-93A0-ED94CB4D203A.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AO-A0JM/1.3.6.1.4.1.14519.5.2.1.9203.4002.454728436394916718626245859814/1.3.6.1.4.1.14519.5.2.1.9203.4002.114399706254337368650501059482",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AO-A0JM-01A__baddabcd-a902-4add-ba54-cc1b45e40ea2.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AO-A0JM__cd9fd232-1d69-4ef0-911d-28130243994f.pt | |||||
TCGA-AO-A0JM | TCGA-BRCA | 5,205,938,156,161,452,000 | 8,600,973,972,091,778,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Irregular nests and cords in prominent desmoplastic stroma with brisk lymphoid-rich tumor-stroma interface inflammation. | Haphazard small angulated glands, tubules, and cords in dense collagenized desmoplasia with limited inflammation and adipose invasion. | Predominant trabecular and irregular nest architecture with geographic pallor, hemorrhagic stromal injury/necrosis, and patchy stromal lymphocytes. | Irregular angulated tubules with small nests and cords in dense desmoplastic stroma, plus conspicuous lymphoid aggregates. | Haphazard small angulated glands, tubules, and cords in dense collagenized desmoplasia with limited inflammation and adipose invasion. | B | TCGA-AO-A0JM | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-AO-A0JM-01Z-00-DX1.94E75EFD-E5F5-4DF8-93A0-ED94CB4D203A.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AO-A0JM/1.3.6.1.4.1.14519.5.2.1.9203.4002.454728436394916718626245859814/1.3.6.1.4.1.14519.5.2.1.9203.4002.114399706254337368650501059482",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AO-A0JM-01A__baddabcd-a902-4add-ba54-cc1b45e40ea2.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AO-A0JM__cd9fd232-1d69-4ef0-911d-28130243994f.pt | |||||
TCGA-AO-A0JM | TCGA-BRCA | 6,858,132,529,743,024,000 | 8,327,158,739,603,489,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | TP53 truncation with biallelic-appearing PTEN loss; basal-like RNA labeling despite HER2/ERBB2-high, ESR1/PGR-low expression. | LumA, ESR1/FOXA1/GATA3-high, MKI67-low; mutation- and copy-number–silent; high BRCA1 and ESR1 promoter methylation; ER-high/PR-low/HER2-low. | LumB transcriptomic subtype with ESR1/FOXA1/GATA3 and ERBB2 RNA expression, genomically quiet, low TMB, ESR1/GSTP1 methylation. | Basal-like, ESR1/PGR-low, HER2-low transcriptome with MYC, interferon, and unfolded protein response enrichment; mutation/copy-number silent; TMB 0.03. | LumB transcriptomic subtype with ESR1/FOXA1/GATA3 and ERBB2 RNA expression, genomically quiet, low TMB, ESR1/GSTP1 methylation. | C | TCGA-AO-A0JM | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-AO-A0JM-01Z-00-DX1.94E75EFD-E5F5-4DF8-93A0-ED94CB4D203A.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AO-A0JM/1.3.6.1.4.1.14519.5.2.1.9203.4002.454728436394916718626245859814/1.3.6.1.4.1.14519.5.2.1.9203.4002.114399706254337368650501059482",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AO-A0JM-01A__baddabcd-a902-4add-ba54-cc1b45e40ea2.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AO-A0JM__cd9fd232-1d69-4ef0-911d-28130243994f.pt | |||||
TCGA-AO-A0JM | TCGA-BRCA | 1,563,141,250,366,584,600 | 6,253,431,367,140,380,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Infiltrative gland-forming carcinoma matched to irregular enhancing mass, with luminal B expression despite absent detectable driver alterations. | Lobular-pattern discohesive infiltrative carcinoma chiefly distinguished by luminal transcriptional support without morphology-defining driver alteration. | Desmoplastic invasive duct-forming carcinoma with necrotic foci and fat infiltration paired with RNA-level HER2-driven biology lacking DNA amplification. | Copy-number-quiet luminal invasive carcinoma combining strongly gland-forming desmoplastic morphology with PI3K-activated, HR-proficient, ER-high biology. | Infiltrative gland-forming carcinoma matched to irregular enhancing mass, with luminal B expression despite absent detectable driver alterations. | A | TCGA-AO-A0JM | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-AO-A0JM-01Z-00-DX1.94E75EFD-E5F5-4DF8-93A0-ED94CB4D203A.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AO-A0JM/1.3.6.1.4.1.14519.5.2.1.9203.4002.454728436394916718626245859814/1.3.6.1.4.1.14519.5.2.1.9203.4002.114399706254337368650501059482",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AO-A0JM-01A__baddabcd-a902-4add-ba54-cc1b45e40ea2.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AO-A0JM__cd9fd232-1d69-4ef0-911d-28130243994f.pt | |||||
TCGA-AO-A12F | TCGA-BRCA | 9,063,184,297,170,379,000 | 6,575,269,353,482,634,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Irregular non-mass to mass-like enhancement with clumped/streaky tissue and later faint linear-patchy enhancement. | Dominant irregular mass-like breast lesion with conspicuous heterogeneous enhancement and nearby smaller enhancing foci. | Large irregular heterogeneous enhancing mass occupying much of imaged breast parenchyma, with patchy brighter internal foci and partly indistinct lobulated margins. | Focal posterior breast mass at pectoralis/chest wall interface, irregular heterogeneous enhancement, mass-like rather than nonmass or diffuse. | Large irregular heterogeneous enhancing mass occupying much of imaged breast parenchyma, with patchy brighter internal foci and partly indistinct lobulated margins. | C | TCGA-AO-A12F | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-AO-A12F-01Z-00-DX1.847C8E4F-3F37-4B1D-8E6E-ACD14391AD89.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AO-A12F/1.3.6.1.4.1.14519.5.2.1.9203.4002.240753407080370737439271619596/1.3.6.1.4.1.14519.5.2.1.9203.4002.113170262927555385612922478544",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AO-A12F-01A__bad2eefd-6cc3-4c6a-abd9-d51540a2ce9d.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AO-A12F__d6882616-b77d-4d4c-90dc-7318c57876e1.pt | |||||
TCGA-AO-A12F | TCGA-BRCA | 42,100,142,512,233,784 | 5,366,723,286,272,082,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Compact trabecular-to-solid invasive carcinoma with limited luminal formation, monomorphic hyperchromatic cells, scant inflammation, and no conspicuous necrosis. | Lymphoid-rich fibrosing stroma with broad fibrous bands, chronic inflammation, whorled fascicular sclerosis, and only scattered entrapped gland-like epithelium. | Haphazard irregular glands, small tubules, and cords in fibrotic-desmoplastic stroma, extending near adipose tissue with patchy chronic inflammation. | Irregular nests and expansile nodular islands in desmoplastic stroma with large central acellular eosinophilic zones, comedo-like necrosis, and patchy inflammation. | Irregular nests and expansile nodular islands in desmoplastic stroma with large central acellular eosinophilic zones, comedo-like necrosis, and patchy inflammation. | D | TCGA-AO-A12F | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-AO-A12F-01Z-00-DX1.847C8E4F-3F37-4B1D-8E6E-ACD14391AD89.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AO-A12F/1.3.6.1.4.1.14519.5.2.1.9203.4002.240753407080370737439271619596/1.3.6.1.4.1.14519.5.2.1.9203.4002.113170262927555385612922478544",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AO-A12F-01A__bad2eefd-6cc3-4c6a-abd9-d51540a2ce9d.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AO-A12F__d6882616-b77d-4d4c-90dc-7318c57876e1.pt | |||||
TCGA-AO-A12F | TCGA-BRCA | 7,417,669,452,316,885,000 | 3,652,568,074,087,856,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | GATA3 frameshift with otherwise driver-sparse, copy-number quiet genome; very low TMB; ESR1/PGR/FOXA1/GATA3 expression; LumA registry versus LumB RNA. | Truncating GATA3 frameshift with LumA subtype, strong ESR1/GATA3 expression, low PR, HER2-low, and no copy-number alterations. | TP53 missense plus MAP2K4 splice-site loss; LumA with high ESR1/FOXA1/GATA3, lower PR, HER2-low, copy-number quiet. | Basal registry subtype with separate HER2-enriched RNA signal; low ESR1/PGR, measurable ERBB2/GATA3, mutation-sparse copy-number-neutral low-TMB low-HRD profile. | Basal registry subtype with separate HER2-enriched RNA signal; low ESR1/PGR, measurable ERBB2/GATA3, mutation-sparse copy-number-neutral low-TMB low-HRD profile. | D | TCGA-AO-A12F | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-AO-A12F-01Z-00-DX1.847C8E4F-3F37-4B1D-8E6E-ACD14391AD89.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AO-A12F/1.3.6.1.4.1.14519.5.2.1.9203.4002.240753407080370737439271619596/1.3.6.1.4.1.14519.5.2.1.9203.4002.113170262927555385612922478544",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AO-A12F-01A__bad2eefd-6cc3-4c6a-abd9-d51540a2ce9d.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AO-A12F__d6882616-b77d-4d4c-90dc-7318c57876e1.pt | |||||
TCGA-AO-A12F | TCGA-BRCA | 1,718,867,579,739,932,700 | 4,503,899,847,219,802,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Hormone receptor-driven luminal A invasive tubule-forming carcinoma with PI3K-pathway dysregulation and fibroadipose invasion. | Immune-rich poorly differentiated non-luminal breast carcinoma, TP53-driven, lacking HRD and classic luminal pathway alterations. | Substantial necrotic solid-nested breast carcinoma with mixed basal/HER2-enriched transcriptional phenotype despite absence of canonical driver or genomic instability. | Lobular-pattern discohesive infiltrative carcinoma chiefly distinguished by luminal transcriptional support without morphology-defining driver alteration. | Substantial necrotic solid-nested breast carcinoma with mixed basal/HER2-enriched transcriptional phenotype despite absence of canonical driver or genomic instability. | C | TCGA-AO-A12F | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-AO-A12F-01Z-00-DX1.847C8E4F-3F37-4B1D-8E6E-ACD14391AD89.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AO-A12F/1.3.6.1.4.1.14519.5.2.1.9203.4002.240753407080370737439271619596/1.3.6.1.4.1.14519.5.2.1.9203.4002.113170262927555385612922478544",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AO-A12F-01A__bad2eefd-6cc3-4c6a-abd9-d51540a2ce9d.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AO-A12F__d6882616-b77d-4d4c-90dc-7318c57876e1.pt | |||||
TCGA-AR-A24R | TCGA-BRCA | 3,309,521,828,127,305,000 | 84,217,550,187,795,060 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Irregular hyperintense enhancing breast mass with internal heterogeneity and a conspicuous bright enhancing focus. | Small subtle enhancing focus in central retroareolar breast without confidently circumscribed mass contour. | Small irregular ill-defined lesion in lateral-to-upper breast ROI on sagittal MRI. | Irregular noncircumscribed breast parenchymal lesion with heterogeneous enhancement on MRI. | Small irregular ill-defined lesion in lateral-to-upper breast ROI on sagittal MRI. | C | TCGA-AR-A24R | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-AR-A24R-01Z-00-DX1.47D79205-63E7-43E6-A513-2CD10DFA53C9.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AR-A24R/1.3.6.1.4.1.14519.5.2.1.3344.4002.497562410445823123071683209253/1.3.6.1.4.1.14519.5.2.1.3344.4002.102442138533365127368023843246",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AR-A24R-01A__93286a9c-b0b5-4068-824b-b6a4e35d8055.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AR-A24R__7e035247-3586-443f-a94c-0addbaf3b17f.pt | |||||
TCGA-AR-A24R | TCGA-BRCA | 364,705,288,443,210,800 | 4,123,103,339,279,527,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Heterogeneous gland-forming carcinoma with irregular angulated glands, small tubules, fused nests, and focal cribriform-solid areas in dense desmoplasia. | Densely packed small-medium cells in nests, cords, trabeculae, vaguely whorled desmoplastic stroma with mild patchy inflammation. | Densely cellular syncytial-sheet carcinoma with scant stroma and brisk diffuse lymphoplasmacytic infiltrate; focal peripheral adipose involvement. | Irregular angulated glands with cribriform-fused nests in broad collagenized desmoplastic bands, forming patchy infiltrative islands. | Densely packed small-medium cells in nests, cords, trabeculae, vaguely whorled desmoplastic stroma with mild patchy inflammation. | B | TCGA-AR-A24R | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-AR-A24R-01Z-00-DX1.47D79205-63E7-43E6-A513-2CD10DFA53C9.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AR-A24R/1.3.6.1.4.1.14519.5.2.1.3344.4002.497562410445823123071683209253/1.3.6.1.4.1.14519.5.2.1.3344.4002.102442138533365127368023843246",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AR-A24R-01A__93286a9c-b0b5-4068-824b-b6a4e35d8055.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AR-A24R__7e035247-3586-443f-a94c-0addbaf3b17f.pt | |||||
TCGA-AR-A24R | TCGA-BRCA | 5,277,748,112,508,464,000 | 7,556,386,687,366,729,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | RUNX1 frameshift-only driver landscape; LumB with ESR1/PGR/FOXA1/GATA3 expression, MKI67 elevated, copy-number quiet. | PIK3CA H1047R and truncating GATA3 frameshift; LumA with HER2-low signaling, low MKI67, copy-number quiet, low TMB/HRD. | Basal-like subtype with TP53 R175H and PTEN H123D; low ESR1/PGR, low HER2 concordance, proliferative and EMT programs. | No detected panel mutations or copy-number changes; high ESR1/FOXA1/GATA3 with lower PGR; LumA registry but LumB RNA call. | RUNX1 frameshift-only driver landscape; LumB with ESR1/PGR/FOXA1/GATA3 expression, MKI67 elevated, copy-number quiet. | A | TCGA-AR-A24R | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-AR-A24R-01Z-00-DX1.47D79205-63E7-43E6-A513-2CD10DFA53C9.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AR-A24R/1.3.6.1.4.1.14519.5.2.1.3344.4002.497562410445823123071683209253/1.3.6.1.4.1.14519.5.2.1.3344.4002.102442138533365127368023843246",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AR-A24R-01A__93286a9c-b0b5-4068-824b-b6a4e35d8055.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AR-A24R__7e035247-3586-443f-a94c-0addbaf3b17f.pt | |||||
TCGA-AR-A24R | TCGA-BRCA | 1,609,558,499,194,469,600 | 8,465,051,102,766,762,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Invasive desmoplastic carcinoma extending toward adipose tissue with luminal B biology and unusually low genomic complexity despite RUNX1 loss. | Gland-forming invasive carcinoma with strong luminal-lineage program and exceptionally quiet genome centered on GATA3 alteration. | Desmoplastic infiltrative ductal carcinoma with adipose extension, biologically defined by TP53 loss and luminal-suppressed HER2-associated transcriptional program. | Luminal invasive carcinoma with GATA3-altered lineage program and unusually quiet genome lacking copy-number events or structural rearrangements. | Invasive desmoplastic carcinoma extending toward adipose tissue with luminal B biology and unusually low genomic complexity despite RUNX1 loss. | A | TCGA-AR-A24R | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-AR-A24R-01Z-00-DX1.47D79205-63E7-43E6-A513-2CD10DFA53C9.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk3/pngs/TCGA-BRCA/TCGA-AR-A24R/1.3.6.1.4.1.14519.5.2.1.3344.4002.497562410445823123071683209253/1.3.6.1.4.1.14519.5.2.1.3344.4002.102442138533365127368023843246",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-AR-A24R-01A__93286a9c-b0b5-4068-824b-b6a4e35d8055.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-AR-A24R__7e035247-3586-443f-a94c-0addbaf3b17f.pt | |||||
TCGA-BH-A0B1 | TCGA-BRCA | 7,363,081,139,597,454,000 | 8,916,494,896,702,569,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | false | true | Which radiology finding best matches this case? | Irregular focal parenchymal lesion with indistinct margins and a brighter peripheral focus within fibroglandular tissue. | Irregular heterogeneous enhancing mass spans substantial breast parenchyma, with adjacent chest wall/axillary-side and separate inferior boxed soft-tissue foci. | Irregular spiculated soft-tissue breast mass with radiating linear extensions and internal heterogeneity. | Irregular heterogeneously hyperintense mass with clustered nonuniform internal enhancement; possible adjacent separate parenchymal enhancing focus. | Irregular heterogeneously hyperintense mass with clustered nonuniform internal enhancement; possible adjacent separate parenchymal enhancing focus. | D | TCGA-BH-A0B1 | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-BH-A0B1-01Z-00-DX1.CC60D284-04FB-4B73-90AA-FCE9185DADB6.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0B1/1.3.6.1.4.1.14519.5.2.1.6450.4002.241701955124018203091289893235/1.3.6.1.4.1.14519.5.2.1.6450.4002.126111704622944477264535522865",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0B1__aabb4a65-aff2-4f78-a969-bacbe5b80856.pt | ||||||
TCGA-BH-A0B1 | TCGA-BRCA | 4,741,909,697,549,132,000 | 2,934,200,326,269,143,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | false | true | Which pathology finding best matches this case? | Angulated tubules, small nests, cords, and dispersed single-cell linear infiltration within desmoplastic stroma extending into fat. | Compact trabecular-to-solid invasive carcinoma with limited luminal formation, monomorphic hyperchromatic cells, scant inflammation, and no conspicuous necrosis. | Patchy low-cellularity infiltrative carcinoma with thin cords and small tubules in densely collagenized desmoplasia; mild chronic inflammation; no conspicuous necrosis. | Multinodular solid invasive nests infiltrate fibroadipose tissue, with focal cribriform punctate lumina and conspicuous adipose involvement. | Angulated tubules, small nests, cords, and dispersed single-cell linear infiltration within desmoplastic stroma extending into fat. | A | TCGA-BH-A0B1 | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-BH-A0B1-01Z-00-DX1.CC60D284-04FB-4B73-90AA-FCE9185DADB6.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0B1/1.3.6.1.4.1.14519.5.2.1.6450.4002.241701955124018203091289893235/1.3.6.1.4.1.14519.5.2.1.6450.4002.126111704622944477264535522865",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0B1__aabb4a65-aff2-4f78-a969-bacbe5b80856.pt | ||||||
TCGA-BH-A0B1 | TCGA-BRCA | 1,857,976,465,366,109,400 | 6,286,164,121,435,561,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | false | true | Which genomic finding best matches this case? | Luminal hormone-lineage profile with ER-high/PR-low/HER2-low surrogate, elevated aneuploidy, low HRD, and high ESR1 methylation. | GATA3 frameshift with copy-number-neutral, fusion-negative luminal profile; ESR1/PGR/FOXA1/GATA3 expression, LumA registry but LumB classifier. | Isolated TP53 p.R342P with copy-number-neutral genome, low TMB/HRD, and luminal ESR1/FOXA1/GATA3 expression despite LumA/LumB discordance. | Genomically quiet LumA tumor: no panel mutations or copy-number changes; high ESR1/PGR/FOXA1/GATA3; low TMB 1.08/Mb. | Genomically quiet LumA tumor: no panel mutations or copy-number changes; high ESR1/PGR/FOXA1/GATA3; low TMB 1.08/Mb. | D | TCGA-BH-A0B1 | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-BH-A0B1-01Z-00-DX1.CC60D284-04FB-4B73-90AA-FCE9185DADB6.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0B1/1.3.6.1.4.1.14519.5.2.1.6450.4002.241701955124018203091289893235/1.3.6.1.4.1.14519.5.2.1.6450.4002.126111704622944477264535522865",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0B1__aabb4a65-aff2-4f78-a969-bacbe5b80856.pt | ||||||
TCGA-BH-A0B1 | TCGA-BRCA | 5,736,213,790,894,879,000 | 9,052,373,947,077,840,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | false | true | Which integrated interpretation best matches this case? | Small sampled invasive luminal breast mass with mixed duct-forming and single-cell infiltrative histology, lacking recurrent genomic drivers. | Gland-forming invasive ductal-pattern carcinoma invading adipose tissue, paired with luminal B estrogen-lineage program and convergent PI3K/AKT activation. | Luminal A, ER-high invasive gland-forming carcinoma with immune-rich stroma, biologically simple genome, and isolated TP53-driven pathology-genomic concordance. | Concordant invasive duct-forming carcinoma with luminal hormone-lineage program; molecular profiling chiefly refines subtype beyond morphology. | Small sampled invasive luminal breast mass with mixed duct-forming and single-cell infiltrative histology, lacking recurrent genomic drivers. | A | TCGA-BH-A0B1 | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-BH-A0B1-01Z-00-DX1.CC60D284-04FB-4B73-90AA-FCE9185DADB6.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0B1/1.3.6.1.4.1.14519.5.2.1.6450.4002.241701955124018203091289893235/1.3.6.1.4.1.14519.5.2.1.6450.4002.126111704622944477264535522865",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0B1__aabb4a65-aff2-4f78-a969-bacbe5b80856.pt | ||||||
TCGA-BH-A0BG | TCGA-BRCA | 1,068,110,033,689,334,900 | 5,700,389,785,733,898,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | false | true | Which radiology finding best matches this case? | Irregular upper-central breast parenchymal lesion with heterogeneous patchy internal enhancement and infiltrative non-circumscribed architecture. | Irregular noncircumscribed enhancing focus with internal heterogeneity and variable conspicuity across slices, giving a suspicious infiltrative appearance. | Posterior-central breast MRI lesion is irregular stellate/spiculated, with radiating linear extensions and heterogeneous enhancement near chest wall interface. | Small focal enhancing breast mass with irregular non-circumscribed contours, appearing localized rather than multifocal or nodal-associated. | Small focal enhancing breast mass with irregular non-circumscribed contours, appearing localized rather than multifocal or nodal-associated. | D | TCGA-BH-A0BG | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-BH-A0BG-01Z-00-DX1.0838FB7F-8C85-4687-9F70-D136A1063383.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0BG/1.3.6.1.4.1.14519.5.2.1.6450.4002.219496072079862696210057534066/1.3.6.1.4.1.14519.5.2.1.6450.4002.131555795150149358261388749093",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0BG__742a677b-e99b-4916-bb92-3536c55ee5e3.pt | ||||||
TCGA-BH-A0BG | TCGA-BRCA | 8,510,204,039,885,144,000 | 1,765,337,579,130,401,300 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | false | true | Which pathology finding best matches this case? | Irregular angulated tubules, fused glands, and cribriform-to-nested structures in desmoplastic stroma with patchy chronic inflammation. | Angulated gland-forming nests and cords with variable tubular differentiation in abundant desmoplastic stroma; only mild scattered inflammation. | Heterogeneous infiltrative carcinoma with glands, nests, trabeculae, and cribriform areas in desmoplastic stroma, plus patchy lymphoid infiltrate. | Diffuse discohesive cords and strands infiltrate desmoplastic stroma and adipose tissue, with patchy chronic inflammation and absent gland formation. | Heterogeneous infiltrative carcinoma with glands, nests, trabeculae, and cribriform areas in desmoplastic stroma, plus patchy lymphoid infiltrate. | C | TCGA-BH-A0BG | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-BH-A0BG-01Z-00-DX1.0838FB7F-8C85-4687-9F70-D136A1063383.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0BG/1.3.6.1.4.1.14519.5.2.1.6450.4002.219496072079862696210057534066/1.3.6.1.4.1.14519.5.2.1.6450.4002.131555795150149358261388749093",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0BG__742a677b-e99b-4916-bb92-3536c55ee5e3.pt | ||||||
TCGA-BH-A0BG | TCGA-BRCA | 4,437,238,236,220,111,400 | 1,852,745,952,793,273,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | false | true | Which genomic finding best matches this case? | PIK3CA H1047R and TP53 H193R with LumA, high ESR1/PGR/FOXA1, HER2-low, copy-number quiet profile. | PIK3CA E545K with MAP2K4 missense; LumA, high ESR1/PGR, low HER2 signal, low TMB, HR-proficient, copy-number quiet. | Isolated CDH1 p.R63* truncation with LumB expression, preserved ESR1/PGR/FOXA1/GATA3, and entirely copy-number quiet low-TMB genome. | Basal-designated yet HER2-enriched mRNA profile, relative ERBB2 expression, aneuploidy, moderate chromosomal instability, HRD 19, interferon/cytolytic activity. | Basal-designated yet HER2-enriched mRNA profile, relative ERBB2 expression, aneuploidy, moderate chromosomal instability, HRD 19, interferon/cytolytic activity. | D | TCGA-BH-A0BG | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-BH-A0BG-01Z-00-DX1.0838FB7F-8C85-4687-9F70-D136A1063383.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0BG/1.3.6.1.4.1.14519.5.2.1.6450.4002.219496072079862696210057534066/1.3.6.1.4.1.14519.5.2.1.6450.4002.131555795150149358261388749093",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0BG__742a677b-e99b-4916-bb92-3536c55ee5e3.pt | ||||||
TCGA-BH-A0BG | TCGA-BRCA | 1,044,379,425,679,197,800 | 9,127,742,661,089,315,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | false | true | Which integrated interpretation best matches this case? | Lobular-pattern infiltrative morphology aligns with noncircumscribed subareolar lesion; genomics uniquely shows luminal, genomically quiet GATA3-altered biology. | Basal-like BRCA1/TP53/NF1-altered invasive breast carcinoma with DNA-repair and growth-factor pathway disruption, contrasting luminal comparator cases. | Ductal-pattern invasive carcinoma with hormone receptor-associated luminal B biology lacking defining driver, copy-number event, or HRD signature. | Early localized invasive carcinoma with glandular-solid heterogeneity and immune-activated basal-versus-HER2 transcriptional ambiguity despite absent defining drivers. | Early localized invasive carcinoma with glandular-solid heterogeneity and immune-activated basal-versus-HER2 transcriptional ambiguity despite absent defining drivers. | D | TCGA-BH-A0BG | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-BH-A0BG-01Z-00-DX1.0838FB7F-8C85-4687-9F70-D136A1063383.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0BG/1.3.6.1.4.1.14519.5.2.1.6450.4002.219496072079862696210057534066/1.3.6.1.4.1.14519.5.2.1.6450.4002.131555795150149358261388749093",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0BG__742a677b-e99b-4916-bb92-3536c55ee5e3.pt | ||||||
TCGA-BH-A0BQ | TCGA-BRCA | 2,666,933,266,489,506,000 | 6,568,213,487,476,884,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Dominant rounded-to-irregular enhancing breast mass with internal heterogeneity and adjacent enhancing vascular structures on subtraction MRI. | Small irregular heterogeneously enhancing intraparenchymal breast mass with indistinct margins. | Small mildly heterogeneous enhancing nodular focus in medial posterior right breast parenchyma. | Irregular heterogeneously enhancing breast mass with noncircumscribed configuration and patchy internal signal variation. | Irregular heterogeneously enhancing breast mass with noncircumscribed configuration and patchy internal signal variation. | D | TCGA-BH-A0BQ | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-BH-A0BQ-01Z-00-DX1.F5C6386B-BB2C-49DF-B3B8-6C4B80D060D4.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0BQ/1.3.6.1.4.1.14519.5.2.1.6450.4002.398551894345363033412310478053/1.3.6.1.4.1.14519.5.2.1.6450.4002.122499269301763646121908956218",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0BQ-01A__e881c84a-c04f-4463-8202-aad487ac0fac.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0BQ__68881256-49b8-4a19-87a9-afac4f1841d2.pt | |||||
TCGA-BH-A0BQ | TCGA-BRCA | 4,173,129,776,831,462,400 | 8,288,881,799,977,305,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Abundant pale extracellular mucin with infiltrative angulated glands, cribriform-to-micropapillary clusters, desmoplasia, and patchy lymphoplasmacytic inflammation. | Predominantly papillary carcinoma with arborizing fibrovascular fronds, intraluminal papillae, cribriform-tubular fusion, and angulated invasive glands in desmoplastic stroma. | Uniform infiltrative angulated tubules and fused glands with focal cribriform-micropapillary luminal complexity in prominent desmoplastic stroma. | Invasive carcinoma with solid and cribriform foci and rounded gland containing central eosinophilic comedo-like debris. | Invasive carcinoma with solid and cribriform foci and rounded gland containing central eosinophilic comedo-like debris. | D | TCGA-BH-A0BQ | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-BH-A0BQ-01Z-00-DX1.F5C6386B-BB2C-49DF-B3B8-6C4B80D060D4.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0BQ/1.3.6.1.4.1.14519.5.2.1.6450.4002.398551894345363033412310478053/1.3.6.1.4.1.14519.5.2.1.6450.4002.122499269301763646121908956218",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0BQ-01A__e881c84a-c04f-4463-8202-aad487ac0fac.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0BQ__68881256-49b8-4a19-87a9-afac4f1841d2.pt | |||||
TCGA-BH-A0BQ | TCGA-BRCA | 1,262,604,084,550,399,200 | 7,001,223,960,815,373,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | GATA3 truncating/splice alteration with PIK3CA H1047R; LumA ER-high/PR-low/HER2-low, low MKI67, copy-number silent. | LumA, ER-high/PR-low/HER2-low, strong ESR1/FOXA1/GATA3 with PGR, low MKI67, high ESR1 methylation, no fusions, modest aneuploidy. | TP53 p.R196* truncation with Basal-like RNA subtype, low ER/PR/HER2 surrogates, and exceptionally copy-number quiet genome. | PIK3CA p.E545K hotspot plus truncating GATA3 p.K357*, TP53/CDH1 wild type, luminal expression, copy-number quiet. | PIK3CA p.E545K hotspot plus truncating GATA3 p.K357*, TP53/CDH1 wild type, luminal expression, copy-number quiet. | D | TCGA-BH-A0BQ | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-BH-A0BQ-01Z-00-DX1.F5C6386B-BB2C-49DF-B3B8-6C4B80D060D4.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0BQ/1.3.6.1.4.1.14519.5.2.1.6450.4002.398551894345363033412310478053/1.3.6.1.4.1.14519.5.2.1.6450.4002.122499269301763646121908956218",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0BQ-01A__e881c84a-c04f-4463-8202-aad487ac0fac.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0BQ__68881256-49b8-4a19-87a9-afac4f1841d2.pt | |||||
TCGA-BH-A0BQ | TCGA-BRCA | 7,811,296,172,608,341,000 | 8,757,050,545,935,519,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Scirrhous adipose-invasive ductal carcinoma distinguished by luminal differentiation with isolated AKT1-driven PI3K/AKT signaling and genomically quiet biology. | Luminal-program, genomically quiet duct-forming carcinoma where invasive glandular-desmoplastic morphology aligns with GATA3-altered LumB biology. | Luminal-type infiltrative gland-forming carcinoma with distinctive comedo-like architectural heterogeneity and genomically quiet PIK3CA/GATA3-driven profile. | Desmoplastic invasive ductal-pattern carcinoma aligned with luminal A biology and exceptionally quiet genome, biologically refining stage IIA beyond morphology. | Luminal-type infiltrative gland-forming carcinoma with distinctive comedo-like architectural heterogeneity and genomically quiet PIK3CA/GATA3-driven profile. | C | TCGA-BH-A0BQ | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-BH-A0BQ-01Z-00-DX1.F5C6386B-BB2C-49DF-B3B8-6C4B80D060D4.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0BQ/1.3.6.1.4.1.14519.5.2.1.6450.4002.398551894345363033412310478053/1.3.6.1.4.1.14519.5.2.1.6450.4002.122499269301763646121908956218",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0BQ-01A__e881c84a-c04f-4463-8202-aad487ac0fac.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0BQ__68881256-49b8-4a19-87a9-afac4f1841d2.pt | |||||
TCGA-BH-A0DH | TCGA-BRCA | 7,828,100,671,455,965,000 | 4,849,585,391,782,711,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | false | true | Which radiology finding best matches this case? | Broad central-to-lateral asymmetric heterogeneous enhancement, patchy-to-confluent across a large parenchymal area, with infiltrative non-circumscribed appearance. | Irregular non-circumscribed heterogeneous enhancing mass extends posteriorly toward the chest wall interface. | Broad heterogeneous enhancement with adjacent separate foci, suggesting multifocal or regionally distributed intraparenchymal disease. | Upper-central breast irregular heterogeneous enhancing mass with adjacent small enhancing foci or contiguous extension. | Broad heterogeneous enhancement with adjacent separate foci, suggesting multifocal or regionally distributed intraparenchymal disease. | C | TCGA-BH-A0DH | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-BH-A0DH-01Z-00-DX1.968AA1FD-068C-4B90-8C95-85BF2EFC3E3F.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0DH/1.3.6.1.4.1.14519.5.2.1.6450.4002.319589426461630943566129258184/1.3.6.1.4.1.14519.5.2.1.6450.4002.132961897956430534507673116083",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0DH__73aeda8d-ef07-4d3d-a0fc-643943dd046a.pt | ||||||
TCGA-BH-A0DH | TCGA-BRCA | 5,348,140,804,232,491,000 | 2,796,272,419,243,428,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | false | true | Which pathology finding best matches this case? | Conspicuous peritumoral lymphoid aggregates around duct-forming carcinoma in densely sclerotic desmoplastic stroma with soft-tissue invasion near adipose tissue. | Predominantly angulated glands and small tubules in prominent desmoplastic stroma, with small lymphoid aggregates but no brisk inflammation. | Irregular small nests, cords, and rounded aggregates with focal targetoid involvement around native structures in desmoplastic fibroadipose tissue. | Duct-forming invasive carcinoma with angulated glands, variable tubule formation, and patchy chronic inflammation in desmoplastic stroma. | Predominantly angulated glands and small tubules in prominent desmoplastic stroma, with small lymphoid aggregates but no brisk inflammation. | B | TCGA-BH-A0DH | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-BH-A0DH-01Z-00-DX1.968AA1FD-068C-4B90-8C95-85BF2EFC3E3F.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0DH/1.3.6.1.4.1.14519.5.2.1.6450.4002.319589426461630943566129258184/1.3.6.1.4.1.14519.5.2.1.6450.4002.132961897956430534507673116083",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0DH__73aeda8d-ef07-4d3d-a0fc-643943dd046a.pt | ||||||
TCGA-BH-A0DH | TCGA-BRCA | 8,162,855,248,092,384,000 | 988,803,863,436,786,600 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | false | true | Which genomic finding best matches this case? | PIK3CA p.H1047R hotspot with LumA profile, preserved ESR1/PGR, TP53/CDH1 wild-type, and no focal or arm-level copy-number changes. | Genomically quiet luminal-profile tumor: wild-type TP53/PIK3CA/GATA3, no copy-number events, low TMB, high ESR1 promoter methylation. | CDH1 p.Q23* with PIK3CA p.E542K; LumA, high ESR1/FOXA1/GATA3, TP53 wild-type, copy-number silent, very low TMB. | High aneuploidy, low HRD, high ESR1 promoter methylation, receptor-low ERBB2-high transcripts, discordant basal versus HER2-enriched calls. | Genomically quiet luminal-profile tumor: wild-type TP53/PIK3CA/GATA3, no copy-number events, low TMB, high ESR1 promoter methylation. | B | TCGA-BH-A0DH | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-BH-A0DH-01Z-00-DX1.968AA1FD-068C-4B90-8C95-85BF2EFC3E3F.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0DH/1.3.6.1.4.1.14519.5.2.1.6450.4002.319589426461630943566129258184/1.3.6.1.4.1.14519.5.2.1.6450.4002.132961897956430534507673116083",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0DH__73aeda8d-ef07-4d3d-a0fc-643943dd046a.pt | ||||||
TCGA-BH-A0DH | TCGA-BRCA | 5,323,740,259,179,042,000 | 7,351,537,114,805,336,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | false | true | Which integrated interpretation best matches this case? | Gland-forming desmoplastic invasive carcinoma paired with multifocal-appearing heterogeneous enhancement and exceptionally alteration-sparse luminal biology. | Invasive papillary-patterned luminal breast carcinoma combining desmoplastic-hemorrhagic stromal heterogeneity with strong luminal lineage transcriptional signaling and low proliferation. | Lymphoid-fibrosclerotic sampled breast lesion with minimal epithelium and low-complexity luminal molecular context, fitting noninvasive Tis biology. | Desmoplastic invasive gland-forming carcinoma with adipocyte entrapment plus dual PIK3CA-driven PI3K activation supports luminal-type invasive breast carcinoma. | Gland-forming desmoplastic invasive carcinoma paired with multifocal-appearing heterogeneous enhancement and exceptionally alteration-sparse luminal biology. | A | TCGA-BH-A0DH | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-BH-A0DH-01Z-00-DX1.968AA1FD-068C-4B90-8C95-85BF2EFC3E3F.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0DH/1.3.6.1.4.1.14519.5.2.1.6450.4002.319589426461630943566129258184/1.3.6.1.4.1.14519.5.2.1.6450.4002.132961897956430534507673116083",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0DH__73aeda8d-ef07-4d3d-a0fc-643943dd046a.pt | ||||||
TCGA-BH-A0DV | TCGA-BRCA | 7,706,284,264,225,528,000 | 5,849,571,461,491,180,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Irregular heterogeneous enhancing breast mass with adjacent linear branching enhancement and infiltrative extension into fibroglandular tissue. | Relatively extensive irregular mass-like breast lesion with patchy brighter foci and heterogeneous internal enhancement. | Right breast irregular infiltrative mass with spiculated radiating extensions, central dense component, posterior elongation, and adjacent parenchymal distortion. | Lateral breast parenchymal lesion with asymmetric elongated-irregular soft-tissue density, lacking circumscribed or rim-like appearance. | Relatively extensive irregular mass-like breast lesion with patchy brighter foci and heterogeneous internal enhancement. | B | TCGA-BH-A0DV | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-BH-A0DV-01Z-00-DX1.2F0B5FB3-40F0-4D27-BFAC-390FB9A42B39.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0DV/1.3.6.1.4.1.14519.5.2.1.6450.4002.306814194968468237895545888132/1.3.6.1.4.1.14519.5.2.1.6450.4002.124157583245223287895610008332",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0DV-01A__5bc7d93f-b018-49bc-9e07-6c9aba46f941.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0DV__287a036d-5b2d-4faf-93a0-cf0be006fa6b.pt | |||||
TCGA-BH-A0DV | TCGA-BRCA | 5,984,024,921,490,887,000 | 1,603,881,600,173,298,200 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Small discohesive cells infiltrate in cords, thin trabeculae, ill-defined nests, with focal single-file pattern and adipose extension. | Predominantly small angulated tubules and cords infiltrating fibroadipose tissue in dense desmoplastic stroma, without conspicuous necrosis. | Irregular angulated glands with dispersed infiltrative clusters and adipose extension in prominently desmoplastic stroma; patchy mild chronic inflammation. | Uniform small-intermediate cells infiltrate fibroadipose tissue as irregular nests, thin cords, and small angulated tubule-like structures with RBC extravasation. | Predominantly small angulated tubules and cords infiltrating fibroadipose tissue in dense desmoplastic stroma, without conspicuous necrosis. | B | TCGA-BH-A0DV | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-BH-A0DV-01Z-00-DX1.2F0B5FB3-40F0-4D27-BFAC-390FB9A42B39.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0DV/1.3.6.1.4.1.14519.5.2.1.6450.4002.306814194968468237895545888132/1.3.6.1.4.1.14519.5.2.1.6450.4002.124157583245223287895610008332",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0DV-01A__5bc7d93f-b018-49bc-9e07-6c9aba46f941.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0DV__287a036d-5b2d-4faf-93a0-cf0be006fa6b.pt | |||||
TCGA-BH-A0DV | TCGA-BRCA | 3,231,111,334,102,092,300 | 1,834,226,014,077,760,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | PIK3CA N345K plus TP53 P278L; LumB with ESR1/GATA3 high, PR low, HER2 low, elevated MKI67; copy-number quiet. | PIK3CA p.E545K plus additional PIK3CA missense alterations and truncating MAP3K1 frameshift; quiet copy number; ESR1/PGR/FOXA1/GATA3, LumA. | TP53 p.R213* with BRCA2 p.C3304S; basal-like, ESR1/PGR very low, low HER2 concordance, HRD-like score 26, copy-number quiet. | TP53 frameshift with otherwise copy-number-silent genome; luminal ESR1/FOXA1/GATA3 expression plus BRCA1 and ESR1 promoter methylation. | PIK3CA p.E545K plus additional PIK3CA missense alterations and truncating MAP3K1 frameshift; quiet copy number; ESR1/PGR/FOXA1/GATA3, LumA. | B | TCGA-BH-A0DV | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-BH-A0DV-01Z-00-DX1.2F0B5FB3-40F0-4D27-BFAC-390FB9A42B39.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0DV/1.3.6.1.4.1.14519.5.2.1.6450.4002.306814194968468237895545888132/1.3.6.1.4.1.14519.5.2.1.6450.4002.124157583245223287895610008332",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0DV-01A__5bc7d93f-b018-49bc-9e07-6c9aba46f941.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0DV__287a036d-5b2d-4faf-93a0-cf0be006fa6b.pt | |||||
TCGA-BH-A0DV | TCGA-BRCA | 3,625,985,094,407,719,400 | 6,081,968,104,720,209,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Stromal-rich infiltrative luminal breast carcinoma combining extensive heterogeneous enhancement with tubule-rich desmoplastic invasion and PI3K/MAP3K1-driven LumA biology. | Stromal-rich infiltrative carcinoma with luminal hormone-associated program and reported stage IIIC nodal burden, indicating advanced locoregional luminal breast cancer. | Gland-forming desmoplastic invasive carcinoma paired with multifocal-appearing heterogeneous enhancement and exceptionally alteration-sparse luminal biology. | Invasive ductal-pattern carcinoma with desmoplastic inflammatory stroma and genomically quiet basal-like, hormone-receptor–low biology. | Stromal-rich infiltrative luminal breast carcinoma combining extensive heterogeneous enhancement with tubule-rich desmoplastic invasion and PI3K/MAP3K1-driven LumA biology. | A | TCGA-BH-A0DV | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-BH-A0DV-01Z-00-DX1.2F0B5FB3-40F0-4D27-BFAC-390FB9A42B39.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0DV/1.3.6.1.4.1.14519.5.2.1.6450.4002.306814194968468237895545888132/1.3.6.1.4.1.14519.5.2.1.6450.4002.124157583245223287895610008332",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0DV-01A__5bc7d93f-b018-49bc-9e07-6c9aba46f941.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0DV__287a036d-5b2d-4faf-93a0-cf0be006fa6b.pt | |||||
TCGA-BH-A0E1 | TCGA-BRCA | 8,363,596,619,247,864,000 | 412,884,365,076,267,260 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Irregular hyperintense enhancing breast mass with internal heterogeneity and a conspicuous bright enhancing focus. | Left breast irregular nonmass-like infiltrative lesion with branching linear and spiculated extensions embedded in fibroglandular tissue. | Subtle nonmass intraparenchymal architectural distortion with faint internal linear-branching high signal and mild heterogeneity. | Irregular heterogeneously hyperintense lesion with nearby smaller enhancing foci or regional contiguous enhancement. | Irregular heterogeneously hyperintense lesion with nearby smaller enhancing foci or regional contiguous enhancement. | D | TCGA-BH-A0E1 | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-BH-A0E1-01Z-00-DX1.257EB36A-1008-4890-927B-204EF05DBE90.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0E1/1.3.6.1.4.1.14519.5.2.1.6450.4002.230135803943875629378759266574/1.3.6.1.4.1.14519.5.2.1.6450.4002.102369102160431319071857990096",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0E1-01A__991e8024-e28f-4412-9bf3-99589a69eb62.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0E1__c1ac2f8b-9ff2-47b9-a685-6cf10a7a925f.pt | |||||
TCGA-BH-A0E1 | TCGA-BRCA | 653,263,467,569,056,900 | 2,804,393,499,922,245,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Broad trabeculated islands and rounded irregular nests in dense eosinophilic stromal bands, with uniformly solid growth and scant tubules. | Irregular angulated glands, nests, and crowded tubules in abundant desmoplastic stroma, including a rounded nodular focus. | Rounded lobulated tumor islands infiltrate fibroadipose tissue within prominent desmoplastic stroma, with focal hemorrhagic change. | Diffuse discohesive single-file linear cords with subtle concentric streaming through dense desmoplastic stroma; mild-moderate atypia, sparse chronic inflammation. | Irregular angulated glands, nests, and crowded tubules in abundant desmoplastic stroma, including a rounded nodular focus. | B | TCGA-BH-A0E1 | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-BH-A0E1-01Z-00-DX1.257EB36A-1008-4890-927B-204EF05DBE90.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0E1/1.3.6.1.4.1.14519.5.2.1.6450.4002.230135803943875629378759266574/1.3.6.1.4.1.14519.5.2.1.6450.4002.102369102160431319071857990096",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0E1-01A__991e8024-e28f-4412-9bf3-99589a69eb62.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0E1__c1ac2f8b-9ff2-47b9-a685-6cf10a7a925f.pt | |||||
TCGA-BH-A0E1 | TCGA-BRCA | 7,584,903,746,282,525,000 | 9,214,118,191,616,342,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | PIK3CA p.H1047R with otherwise wild-type common drivers; LumA transcriptome preserving ESR1, PGR, FOXA1, GATA3; copy-number silent. | LumA subtype with ESR1/FOXA1/GATA3 expression, low MKI67, wild-type common breast genes, copy-number neutral, mutation-sparse, low TMB. | Biallelic truncating CDH1 loss with BRCA2 frameshift; TP53/PIK3CA wild-type, copy-number neutral, intermediate TMB, LumA with high ESR1 and lower PGR. | Genomically quiet luminal tumor: no detected driver mutations or copy-number changes; ESR1 and BRCA1 promoter hypermethylation. | Genomically quiet luminal tumor: no detected driver mutations or copy-number changes; ESR1 and BRCA1 promoter hypermethylation. | D | TCGA-BH-A0E1 | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-BH-A0E1-01Z-00-DX1.257EB36A-1008-4890-927B-204EF05DBE90.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0E1/1.3.6.1.4.1.14519.5.2.1.6450.4002.230135803943875629378759266574/1.3.6.1.4.1.14519.5.2.1.6450.4002.102369102160431319071857990096",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0E1-01A__991e8024-e28f-4412-9bf3-99589a69eb62.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0E1__c1ac2f8b-9ff2-47b9-a685-6cf10a7a925f.pt | |||||
TCGA-BH-A0E1 | TCGA-BRCA | 8,175,619,605,403,964,000 | 5,941,483,485,365,788,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Desmoplastic invasive ductal-pattern carcinoma uniquely paired with TP53 loss and strong HER2-associated expression absent DNA-level ERBB2 alteration. | Basal-like invasive ductal-pattern carcinoma combining desmoplastic, gland-forming and solid architecture with dual TP53/PIK3CA pathway alterations. | Invasive gland-forming breast carcinoma with infiltrative MRI appearance and exceptionally low-complexity luminal genomic background. | Invasive gland-forming carcinoma with desmoplastic adipose invasion and exceptionally quiet, copy-number-neutral hormone receptor luminal biology. | Invasive gland-forming breast carcinoma with infiltrative MRI appearance and exceptionally low-complexity luminal genomic background. | C | TCGA-BH-A0E1 | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-BH-A0E1-01Z-00-DX1.257EB36A-1008-4890-927B-204EF05DBE90.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0E1/1.3.6.1.4.1.14519.5.2.1.6450.4002.230135803943875629378759266574/1.3.6.1.4.1.14519.5.2.1.6450.4002.102369102160431319071857990096",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0E1-01A__991e8024-e28f-4412-9bf3-99589a69eb62.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0E1__c1ac2f8b-9ff2-47b9-a685-6cf10a7a925f.pt | |||||
TCGA-BH-A0H3 | TCGA-BRCA | 7,063,762,626,232,466,000 | 5,620,798,105,458,201,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Lateral breast parenchymal lesion with asymmetric elongated-irregular soft-tissue density, lacking circumscribed or rim-like appearance. | Small discrete enhancing focus with adjacent scattered enhancement foci amid prominent background parenchymal enhancement; focal nonmass-like pattern. | Broad central heterogeneous intramammary region with internal linear-branching structures, lacking a discrete circumscribed enhancing mass. | Irregular noncircumscribed lesion with focal-to-confluent enhancement, adjacent smaller enhancing foci, and central bright enhancement region. | Irregular noncircumscribed lesion with focal-to-confluent enhancement, adjacent smaller enhancing foci, and central bright enhancement region. | D | TCGA-BH-A0H3 | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-BH-A0H3-01Z-00-DX1.C6D4DFB9-A4FA-40B2-90EF-75294CBC4523.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0H3/1.3.6.1.4.1.14519.5.2.1.6450.4002.749842838440936488583236961560/1.3.6.1.4.1.14519.5.2.1.6450.4002.102895244054883066169058953347",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0H3-01A__b988a5b1-f58e-476f-83ec-599f31a1b086.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0H3__0e89a7ce-aed2-4c74-9bdf-cf50793c73b6.pt | |||||
TCGA-BH-A0H3 | TCGA-BRCA | 7,445,126,057,952,547,000 | 2,440,715,574,531,778,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Invasive NST with irregular angulated glands and small tubules in abundant desmoplastic stroma plus scattered lymphoid aggregates. | Irregular nests, cords, and rounded islands with central clearing/microcystic luminal spaces in densely desmoplastic stroma, plus patchy hemorrhage. | Conspicuous chronic inflammation with several rounded lymphoid aggregates in densely fibrosclerotic stroma; irregular cords, small nests, and dispersed single cells. | Discohesive single-cell linear infiltrates and small irregular nests/cords within abundant fibrosclerotic stroma, with chronic inflammatory aggregates. | Invasive NST with irregular angulated glands and small tubules in abundant desmoplastic stroma plus scattered lymphoid aggregates. | A | TCGA-BH-A0H3 | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-BH-A0H3-01Z-00-DX1.C6D4DFB9-A4FA-40B2-90EF-75294CBC4523.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0H3/1.3.6.1.4.1.14519.5.2.1.6450.4002.749842838440936488583236961560/1.3.6.1.4.1.14519.5.2.1.6450.4002.102895244054883066169058953347",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0H3-01A__b988a5b1-f58e-476f-83ec-599f31a1b086.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0H3__0e89a7ce-aed2-4c74-9bdf-cf50793c73b6.pt | |||||
TCGA-BH-A0H3 | TCGA-BRCA | 2,573,370,302,765,479,400 | 1,440,223,453,751,488,300 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | LumB with ESR1/FOXA1/GATA3 expression, low PGR, measurable MKI67, high ESR1 and BRCA1 methylation, no driver mutations or CNAs. | PIK3CA p.G1007R with NF1 missense; TP53/CDH1 wild-type; low TMB, low HRD, copy-number neutral; ER-high PR-low HER2-low. | PIK3CA N345K with GATA3, NCOR1, and RUNX1 truncating/splice alterations; LumA, early estrogen-response, copy-number silent. | MAP3K1 splice-site loss; TP53/PIK3CA/GATA3/CDH1 wild type; low TMB 0.97, HRD 4; luminal markers strong despite Normal-like call. | PIK3CA N345K with GATA3, NCOR1, and RUNX1 truncating/splice alterations; LumA, early estrogen-response, copy-number silent. | C | TCGA-BH-A0H3 | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-BH-A0H3-01Z-00-DX1.C6D4DFB9-A4FA-40B2-90EF-75294CBC4523.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0H3/1.3.6.1.4.1.14519.5.2.1.6450.4002.749842838440936488583236961560/1.3.6.1.4.1.14519.5.2.1.6450.4002.102895244054883066169058953347",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0H3-01A__b988a5b1-f58e-476f-83ec-599f31a1b086.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0H3__0e89a7ce-aed2-4c74-9bdf-cf50793c73b6.pt | |||||
TCGA-BH-A0H3 | TCGA-BRCA | 120,138,452,136,439,860 | 4,174,623,115,530,565,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Aggressive non-luminal carcinoma marked by necrosis and inflammation, with mixed basal/HER2-enriched expression on a TP53-driven quiet genome. | Concordant invasive gland-forming breast carcinoma with uniquely strong luminal A, PIK3CA/GATA3-altered, genomically quiet biology. | Lymphoid-fibrosclerotic sampled breast lesion with minimal epithelium and low-complexity luminal molecular context, fitting noninvasive Tis biology. | Right-sided small tubule-forming invasive luminal carcinoma with distinctive PIK3CA/MAP3K1-driven LumA hormone-signaling profile. | Concordant invasive gland-forming breast carcinoma with uniquely strong luminal A, PIK3CA/GATA3-altered, genomically quiet biology. | B | TCGA-BH-A0H3 | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-BH-A0H3-01Z-00-DX1.C6D4DFB9-A4FA-40B2-90EF-75294CBC4523.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0H3/1.3.6.1.4.1.14519.5.2.1.6450.4002.749842838440936488583236961560/1.3.6.1.4.1.14519.5.2.1.6450.4002.102895244054883066169058953347",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0H3-01A__b988a5b1-f58e-476f-83ec-599f31a1b086.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0H3__0e89a7ce-aed2-4c74-9bdf-cf50793c73b6.pt | |||||
TCGA-BH-A0H7 | TCGA-BRCA | 7,507,927,224,145,053,000 | 6,425,439,339,524,298,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Broader regional irregular heterogeneous enhancement with ill-defined to spiculated interface, beyond the smaller central ROI. | Large ROI-spanning asymmetric regional enhancement with patchy internal high-signal foci and irregular non-circumscribed configuration. | Dominant rounded-to-irregular enhancing breast mass with internal heterogeneity and adjacent enhancing vascular structures on subtraction MRI. | Small localized MRI enhancing focus with angular irregular shape and nonuniform internal enhancement in fibroglandular tissue. | Large ROI-spanning asymmetric regional enhancement with patchy internal high-signal foci and irregular non-circumscribed configuration. | B | TCGA-BH-A0H7 | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-BH-A0H7-01Z-00-DX1.21502FEA-DB37-4630-BA42-778DDF3A6D17.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0H7/1.3.6.1.4.1.14519.5.2.1.6450.4002.214806671505118512040570896862/1.3.6.1.4.1.14519.5.2.1.6450.4002.101612527905308942254141087199",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0H7-01A__298bc93c-2450-42f1-a841-2a5daf4511e4.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0H7__15f5f60a-13f0-41a2-8711-171d19c2903a.pt | |||||
TCGA-BH-A0H7 | TCGA-BRCA | 4,174,943,402,820,704,000 | 6,450,986,044,436,098,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Discohesive single cells and thin cords infiltrate dense collagenized desmoplastic stroma with fibroadipose extension and patchy chronic inflammation. | Irregular solid nests and vaguely lobulated syncytial tumor islands in prominent hyalinized desmoplastic stroma. | Irregular angulated tubules and small glands in dense desmoplasia with conspicuous nodular lymphoid aggregates at tumor-stromal interface. | Crowded angulated glands, slit-like tubules, and irregular anastomosing nests with variably solid/trabecular areas; no conspicuous lymphoid-rich inflammation. | Irregular angulated tubules and small glands in dense desmoplasia with conspicuous nodular lymphoid aggregates at tumor-stromal interface. | C | TCGA-BH-A0H7 | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-BH-A0H7-01Z-00-DX1.21502FEA-DB37-4630-BA42-778DDF3A6D17.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0H7/1.3.6.1.4.1.14519.5.2.1.6450.4002.214806671505118512040570896862/1.3.6.1.4.1.14519.5.2.1.6450.4002.101612527905308942254141087199",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0H7-01A__298bc93c-2450-42f1-a841-2a5daf4511e4.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0H7__15f5f60a-13f0-41a2-8711-171d19c2903a.pt | |||||
TCGA-BH-A0H7 | TCGA-BRCA | 7,768,417,720,980,807,000 | 7,386,602,657,917,663,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | TP53 p.G245D mutation with copy-number-neutral, low-TMB, HR-proficient luminal-pattern profile lacking PIK3CA alteration. | Basal registry subtype with separate HER2-enriched RNA signal; low ESR1/PGR, measurable ERBB2/GATA3, mutation-sparse copy-number-neutral low-TMB low-HRD profile. | Normal-like, HR-proficient, copy-number-quiet profile with aneuploidy 0, HRD 0, high ESR1 promoter methylation, no driver alteration. | Mutation- and copy-number-silent tumor; basal designation despite HER2-enriched mRNA label, with ER-low/PR-low/HER2-low expression. | TP53 p.G245D mutation with copy-number-neutral, low-TMB, HR-proficient luminal-pattern profile lacking PIK3CA alteration. | A | TCGA-BH-A0H7 | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-BH-A0H7-01Z-00-DX1.21502FEA-DB37-4630-BA42-778DDF3A6D17.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0H7/1.3.6.1.4.1.14519.5.2.1.6450.4002.214806671505118512040570896862/1.3.6.1.4.1.14519.5.2.1.6450.4002.101612527905308942254141087199",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0H7-01A__298bc93c-2450-42f1-a841-2a5daf4511e4.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0H7__15f5f60a-13f0-41a2-8711-171d19c2903a.pt | |||||
TCGA-BH-A0H7 | TCGA-BRCA | 7,441,249,032,925,285,000 | 5,825,932,914,087,652,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Concordant infiltrative lobular-pattern breast carcinoma combining extensive nonmass enhancement, single-file stromal permeation, and low-complexity luminal A biology. | Luminal-type invasive carcinoma with combined PI3K activation and TP53 disruption, showing more proliferative LumB biology than comparator luminal cases. | Infiltrative adipose-invasive desmoplastic carcinoma matches broad regional heterogeneous MRI abnormality, with TP53-mutant but otherwise genomically quiet luminal biology. | Gland-forming invasive carcinoma with brisk lymphoid stroma aligns with TP53-mutant basal-like, immune-reactive, low-genomic-complexity biology. | Infiltrative adipose-invasive desmoplastic carcinoma matches broad regional heterogeneous MRI abnormality, with TP53-mutant but otherwise genomically quiet luminal biology. | C | TCGA-BH-A0H7 | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-BH-A0H7-01Z-00-DX1.21502FEA-DB37-4630-BA42-778DDF3A6D17.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk4/pngs/TCGA-BRCA/TCGA-BH-A0H7/1.3.6.1.4.1.14519.5.2.1.6450.4002.214806671505118512040570896862/1.3.6.1.4.1.14519.5.2.1.6450.4002.101612527905308942254141087199",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0H7-01A__298bc93c-2450-42f1-a841-2a5daf4511e4.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0H7__15f5f60a-13f0-41a2-8711-171d19c2903a.pt | |||||
TCGA-BH-A0HI | TCGA-BRCA | 7,622,262,173,896,119,000 | 1,575,007,739,794,844,700 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Irregular heterogeneously enhancing mass-like breast lesion with adjacent patchy regional enhancement on MRI. | Subtle nonmass intraparenchymal architectural distortion with faint internal linear-branching high signal and mild heterogeneity. | Broad heterogeneous enhancement with adjacent separate foci, suggesting multifocal or regionally distributed intraparenchymal disease. | Broad central-to-lateral asymmetric heterogeneous enhancement, patchy-to-confluent across a large parenchymal area, with infiltrative non-circumscribed appearance. | Irregular heterogeneously enhancing mass-like breast lesion with adjacent patchy regional enhancement on MRI. | A | TCGA-BH-A0HI | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-BH-A0HI-01Z-00-DX1.89DB9F79-0DCC-4C65-831E-96AE026C2C4E.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk5/pngs/TCGA-BRCA/TCGA-BH-A0HI/1.3.6.1.4.1.14519.5.2.1.6450.4002.155856231925238279250135085477/1.3.6.1.4.1.14519.5.2.1.6450.4002.103005588934585006571407333161",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0HI-01A__c8596dd1-09fa-41f6-8064-dc881bdb6d72.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0HI__36a42825-dbc2-4dff-828c-e5008207d254.pt | |||||
TCGA-BH-A0HI | TCGA-BRCA | 1,393,995,512,185,729,300 | 9,209,989,797,702,198,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Cohesive infiltrative carcinoma forming confluent islands and trabecular cords, with geographic nodules and brisk lymphoid inflammatory aggregates. | Irregular angulated glands, small nests, and trabeculae in abundant desmoplastic stroma, invading adjacent adipose tissue. | Predominantly angulated tubules and cords infiltrating between adipocytes in abundant fibrosclerotic stroma, without necrosis or dense inflammation. | High-cellularity infiltrative carcinoma in fibroadipose tissue with elongated cords, patchy stromal separation, and densely collagenized desmoplastic stroma. | Irregular angulated glands, small nests, and trabeculae in abundant desmoplastic stroma, invading adjacent adipose tissue. | B | TCGA-BH-A0HI | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-BH-A0HI-01Z-00-DX1.89DB9F79-0DCC-4C65-831E-96AE026C2C4E.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk5/pngs/TCGA-BRCA/TCGA-BH-A0HI/1.3.6.1.4.1.14519.5.2.1.6450.4002.155856231925238279250135085477/1.3.6.1.4.1.14519.5.2.1.6450.4002.103005588934585006571407333161",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0HI-01A__c8596dd1-09fa-41f6-8064-dc881bdb6d72.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0HI__36a42825-dbc2-4dff-828c-e5008207d254.pt | |||||
TCGA-BH-A0HI | TCGA-BRCA | 3,948,432,162,361,737,700 | 3,287,627,548,002,172,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | TP53 p.S183* truncation with HER2-enriched mRNA subtype, very high ERBB2 and low ESR1/PGR expression; TMB 10.84/Mb. | PIK3CA hotspot H1047R with V344M; LumA, ER/PR-high, FOXA1/GATA3-high, low MKI67, copy-number neutral, TP53 wild-type. | PIK3CA p.E545K hotspot with LumA expression; high ESR1, FOXA1, GATA3 and quiet copy-number profile. | CDH1 missense mutation with otherwise driver-wild-type, copy-number silent, low-TMB low-HRD LumA luminal expression profile. | PIK3CA p.E545K hotspot with LumA expression; high ESR1, FOXA1, GATA3 and quiet copy-number profile. | C | TCGA-BH-A0HI | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-BH-A0HI-01Z-00-DX1.89DB9F79-0DCC-4C65-831E-96AE026C2C4E.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk5/pngs/TCGA-BRCA/TCGA-BH-A0HI/1.3.6.1.4.1.14519.5.2.1.6450.4002.155856231925238279250135085477/1.3.6.1.4.1.14519.5.2.1.6450.4002.103005588934585006571407333161",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0HI-01A__c8596dd1-09fa-41f6-8064-dc881bdb6d72.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0HI__36a42825-dbc2-4dff-828c-e5008207d254.pt | |||||
TCGA-BH-A0HI | TCGA-BRCA | 8,087,647,407,845,936,000 | 1,230,990,947,920,777,700 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Concordant invasive duct-forming carcinoma with luminal A, hormone-lineage, HR-proficient-like biology; non-basal, non-fusion-defined phenotype. | Stromally infiltrative carcinoma with pronounced desmoplasia aligned to hormone-driven LumA biology despite absent recurrent genomic drivers. | Concordant invasive gland-forming luminal breast carcinoma with PI3K-pathway activation and MRI-visible irregular enhancing lesion. | Uniform tubulocord invasive carcinoma with strongly hormone-driven LumA program and exceptionally low genomic complexity. | Concordant invasive gland-forming luminal breast carcinoma with PI3K-pathway activation and MRI-visible irregular enhancing lesion. | C | TCGA-BH-A0HI | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-BH-A0HI-01Z-00-DX1.89DB9F79-0DCC-4C65-831E-96AE026C2C4E.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk5/pngs/TCGA-BRCA/TCGA-BH-A0HI/1.3.6.1.4.1.14519.5.2.1.6450.4002.155856231925238279250135085477/1.3.6.1.4.1.14519.5.2.1.6450.4002.103005588934585006571407333161",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0HI-01A__c8596dd1-09fa-41f6-8064-dc881bdb6d72.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0HI__36a42825-dbc2-4dff-828c-e5008207d254.pt | |||||
TCGA-BH-A0W3 | TCGA-BRCA | 1,650,943,703,335,036,700 | 1,421,835,649,720,481,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Unilateral irregular heterogeneous enhancing breast mass with asymmetric focal enhancement amid substantial background parenchymal enhancement. | Irregular broadly extensive heterogeneous enhancing breast mass on coronal MRI, with mixed higher and lower internal enhancement. | Small focal enhancing lesion marked by narrow ROI, more discrete than diffuse background parenchymal enhancement. | Irregular spiculated stellate breast mass with heterogeneous enhancement and small adjacent enhancing foci near superficial vessels. | Small focal enhancing lesion marked by narrow ROI, more discrete than diffuse background parenchymal enhancement. | C | TCGA-BH-A0W3 | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-BH-A0W3-01Z-00-DX1.38DCA2B7-1A54-4FFA-BABA-29F80974BB17.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk5/pngs/TCGA-BRCA/TCGA-BH-A0W3/1.3.6.1.4.1.14519.5.2.1.6450.4002.725390403520548797579242309153/1.3.6.1.4.1.14519.5.2.1.6450.4002.162931332219787279508055510988",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0W3-01A__1f84d4c4-4396-4bd4-8664-5ef0989d131a.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0W3__f8e5691a-e24d-4dba-873e-9ffa3ca12bb6.pt | |||||
TCGA-BH-A0W3 | TCGA-BRCA | 2,505,092,858,166,777,000 | 7,440,196,227,160,963,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Heterogeneous invasive ductal-type carcinoma with brisk lymphoplasmacytic infiltrates at invasive front and fibrosis-dominant areas alternating with cellular foci. | Duct-like space involvement by cohesive epithelial proliferations with mixed gland-forming and stromally dominant spindle-cell reactive areas. | Mixed glandular-cribriform and stromal-rich infiltrative nests, cords, and trabeculae with chronic inflammation extending into adipose tissue. | Scirrhous carcinoma of angulated cords and narrow tubules in collagenized desmoplastic stroma with conspicuous lymphoplasmacytic infiltrate. | Mixed glandular-cribriform and stromal-rich infiltrative nests, cords, and trabeculae with chronic inflammation extending into adipose tissue. | C | TCGA-BH-A0W3 | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-BH-A0W3-01Z-00-DX1.38DCA2B7-1A54-4FFA-BABA-29F80974BB17.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk5/pngs/TCGA-BRCA/TCGA-BH-A0W3/1.3.6.1.4.1.14519.5.2.1.6450.4002.725390403520548797579242309153/1.3.6.1.4.1.14519.5.2.1.6450.4002.162931332219787279508055510988",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0W3-01A__1f84d4c4-4396-4bd4-8664-5ef0989d131a.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0W3__f8e5691a-e24d-4dba-873e-9ffa3ca12bb6.pt | |||||
TCGA-BH-A0W3 | TCGA-BRCA | 6,415,791,145,953,645,000 | 4,099,248,645,870,001,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | PIK3CA E542K-mutant LumB profile with high ESR1, lower PR than ER, and otherwise copy-number-silent genome. | No detectable driver mutations or copy-number changes; LumA with high ESR1 methylation, low TMB 0.42/Mb, low HRD 8. | PTEN and MAP2K4 splice-site loss plus NF1 mutation; LumB with high MKI67/MYC targets; copy-number neutral, low HRD/TMB. | AKT1 E17K and MAP3K1 Y392C co-mutation; LumB with high ESR1/PGR, HER2-low, copy-number silent, low TMB, BRCA1/ESR1 methylation. | PIK3CA E542K-mutant LumB profile with high ESR1, lower PR than ER, and otherwise copy-number-silent genome. | A | TCGA-BH-A0W3 | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-BH-A0W3-01Z-00-DX1.38DCA2B7-1A54-4FFA-BABA-29F80974BB17.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk5/pngs/TCGA-BRCA/TCGA-BH-A0W3/1.3.6.1.4.1.14519.5.2.1.6450.4002.725390403520548797579242309153/1.3.6.1.4.1.14519.5.2.1.6450.4002.162931332219787279508055510988",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0W3-01A__1f84d4c4-4396-4bd4-8664-5ef0989d131a.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0W3__f8e5691a-e24d-4dba-873e-9ffa3ca12bb6.pt | |||||
TCGA-BH-A0W3 | TCGA-BRCA | 7,832,951,998,108,659,000 | 9,106,049,733,289,098,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Morphology is ductal/invasive carcinoma-like rather than lobular, aligning with TP53-altered basal phenotype despite low-complexity genomics. | Desmoplastic scirrhous infiltrative breast carcinoma with luminal A biology and low HRD signal, without lobular-specific genomic drivers. | Concordant small MRI focus and heterogeneous invasive carcinoma; uniquely LumB biology driven by PIK3CA E542K without additional recurrent alterations. | Posterior heterogeneous breast lesion aligns with luminal A, hormone receptor-associated, genomically quiet carcinoma uniquely marked by PTEN loss. | Concordant small MRI focus and heterogeneous invasive carcinoma; uniquely LumB biology driven by PIK3CA E542K without additional recurrent alterations. | C | TCGA-BH-A0W3 | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-BH-A0W3-01Z-00-DX1.38DCA2B7-1A54-4FFA-BABA-29F80974BB17.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk5/pngs/TCGA-BRCA/TCGA-BH-A0W3/1.3.6.1.4.1.14519.5.2.1.6450.4002.725390403520548797579242309153/1.3.6.1.4.1.14519.5.2.1.6450.4002.162931332219787279508055510988",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A0W3-01A__1f84d4c4-4396-4bd4-8664-5ef0989d131a.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A0W3__f8e5691a-e24d-4dba-873e-9ffa3ca12bb6.pt | |||||
TCGA-BH-A18I | TCGA-BRCA | 2,728,391,233,824,404,000 | 9,096,249,684,540,453,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Small localized MRI enhancing focus with angular irregular shape and nonuniform internal enhancement in fibroglandular tissue. | Irregular heterogeneously enhancing focal breast mass with spiculated or indistinct margins amid conspicuous adjacent background parenchymal enhancement. | Irregular heterogeneous parenchymal soft-tissue ROI blending with surrounding tissue, favoring a non-circumscribed infiltrative lesion on sagittal MRI. | Enhancing irregular intraparenchymal mass with heterogeneous internal signal and interspersed linear-to-confluent brighter components. | Irregular heterogeneously enhancing focal breast mass with spiculated or indistinct margins amid conspicuous adjacent background parenchymal enhancement. | B | TCGA-BH-A18I | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-BH-A18I-01Z-00-DX1.EE699DE3-EBF4-4AB4-8319-9911F027FA18.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk5/pngs/TCGA-BRCA/TCGA-BH-A18I/1.3.6.1.4.1.14519.5.2.1.6450.4002.222809693654088599374023454013/1.3.6.1.4.1.14519.5.2.1.6450.4002.108471002213768681727738879420",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A18I-01A__e4ecfee4-a247-4136-8adc-bf3a24dab074.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A18I__3690d431-165d-40bb-af61-cfda445b3be8.pt | |||||
TCGA-BH-A18I | TCGA-BRCA | 6,839,170,462,802,305,000 | 8,608,686,193,744,743,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Dispersed single cells and small linear cords in dense fibrosclerotic stroma, permeating around benign ducts/lobules with conspicuous lymphoid aggregates. | Small angulated tubules and cords infiltrate dense desmoplastic stroma with focal adipose extension and patchy lymphoplasmacytic inflammation. | Markedly scirrhous carcinoma with dense desmoplasia, cord-like tubules/nests, adipose invasion, and focal concentric laminated calcification without conspicuous necrosis. | Predominantly irregular angulated tubules and small glands in abundant desmoplastic stroma, with adjacent adipose invasion and possible intraductal proliferation. | Small angulated tubules and cords infiltrate dense desmoplastic stroma with focal adipose extension and patchy lymphoplasmacytic inflammation. | B | TCGA-BH-A18I | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-BH-A18I-01Z-00-DX1.EE699DE3-EBF4-4AB4-8319-9911F027FA18.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk5/pngs/TCGA-BRCA/TCGA-BH-A18I/1.3.6.1.4.1.14519.5.2.1.6450.4002.222809693654088599374023454013/1.3.6.1.4.1.14519.5.2.1.6450.4002.108471002213768681727738879420",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A18I-01A__e4ecfee4-a247-4136-8adc-bf3a24dab074.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A18I__3690d431-165d-40bb-af61-cfda445b3be8.pt | |||||
TCGA-BH-A18I | TCGA-BRCA | 7,619,310,996,603,691,000 | 1,041,646,003,653,110,400 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | TP53 frameshift truncation; no copy-number changes; low TMB/HRD; mixed basal versus Normal-like expression with retained ESR1, FOXA1, GATA3. | LumA, ER-high/PR-high/HER2-low, mutation-null and copy-number silent, very low TMB 0.45 and HRD 3. | PIK3CA p.E542K hotspot with LumA subtype and ESR1/PGR/FOXA1/GATA3 expression in an otherwise copy-number-neutral profile. | PIK3CA p.E109_I112delinsD with NCOR1 truncation; TP53/CDH1 wild type; copy-number quiet; HRD score 8 HR-proficient-like; mixed luminal/Normal-like. | PIK3CA p.E542K hotspot with LumA subtype and ESR1/PGR/FOXA1/GATA3 expression in an otherwise copy-number-neutral profile. | C | TCGA-BH-A18I | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-BH-A18I-01Z-00-DX1.EE699DE3-EBF4-4AB4-8319-9911F027FA18.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk5/pngs/TCGA-BRCA/TCGA-BH-A18I/1.3.6.1.4.1.14519.5.2.1.6450.4002.222809693654088599374023454013/1.3.6.1.4.1.14519.5.2.1.6450.4002.108471002213768681727738879420",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A18I-01A__e4ecfee4-a247-4136-8adc-bf3a24dab074.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A18I__3690d431-165d-40bb-af61-cfda445b3be8.pt | |||||
TCGA-BH-A18I | TCGA-BRCA | 8,183,491,692,358,190,000 | 2,506,601,896,148,195,300 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Tubule-rich desmoplastic invasive carcinoma aligned with strongly hormone-lineage LumA biology and exceptionally quiet genome centered on RUNX1 loss. | Aggressive ductal-pattern carcinoma distinguished by extensive necrosis plus receptor-low basal transcriptional program despite genomically quiet, HR-proficient background. | Infiltrative MRI mass and gland-forming desmoplastic invasion align with LumA, PIK3CA-mutant hormone receptor-associated breast carcinoma biology. | Discohesive cord-like morphology aligns with CDH1 loss, defining a lobular-type luminal A, PI3K-activated, copy-number-quiet breast carcinoma. | Infiltrative MRI mass and gland-forming desmoplastic invasion align with LumA, PIK3CA-mutant hormone receptor-associated breast carcinoma biology. | C | TCGA-BH-A18I | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-BH-A18I-01Z-00-DX1.EE699DE3-EBF4-4AB4-8319-9911F027FA18.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk5/pngs/TCGA-BRCA/TCGA-BH-A18I/1.3.6.1.4.1.14519.5.2.1.6450.4002.222809693654088599374023454013/1.3.6.1.4.1.14519.5.2.1.6450.4002.108471002213768681727738879420",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-BH-A18I-01A__e4ecfee4-a247-4136-8adc-bf3a24dab074.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-BH-A18I__3690d431-165d-40bb-af61-cfda445b3be8.pt | |||||
TCGA-E2-A105 | TCGA-BRCA | 8,280,334,332,440,432,000 | 7,883,777,766,060,667,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Irregular heterogeneous enhancing mass with central nonenhancing spaces and partially rim-like appearance, suggesting internal necrotic or cystic change. | Irregular elongated to spiculated breast lesion with heterogeneous enhancement and linear/septation-like enhancing elements. | Mass-like to confluent non-mass-like enhancement with patchy avid and less avid internal regions across a substantial boxed region. | Irregular heterogeneous infiltrative breast lesion with patchy internal variation and adjacent smaller/inferior boxed foci. | Irregular elongated to spiculated breast lesion with heterogeneous enhancement and linear/septation-like enhancing elements. | B | TCGA-E2-A105 | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-E2-A105-01Z-00-DX1.192813F9-2D7B-40C7-88D9-BFA939D43FEE.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A105/1.3.6.1.4.1.14519.5.2.1.3023.4002.764533775161819961703293521534/1.3.6.1.4.1.14519.5.2.1.3023.4002.189863101020484121418565300460",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A105-01A__8bc28a3e-1497-40f4-a231-486b76e4a280.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A105__2e60bad2-2dd2-4dc3-aa45-dfc36ef4884b.pt | |||||
TCGA-E2-A105 | TCGA-BRCA | 1,179,315,375,098,163,000 | 1,097,506,988,396,477,800 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Rounded lobulated tumor islands infiltrate fibroadipose tissue within prominent desmoplastic stroma, with focal hemorrhagic change. | Patchy lymphoplasmacytic stromal infiltrate amid irregular glands, cords, and small nests in abundant desmoplastic stroma. | Complex papillary, micropapillary, and cribriform-glandular fronds in delicate fibrovascular stroma with pale stromal spaces and focal dense lymphoid aggregate. | Angulated glands, trabeculae, and nests infiltrate broad sclerotic desmoplastic stroma with variable tubular formation and only mild focal inflammation. | Angulated glands, trabeculae, and nests infiltrate broad sclerotic desmoplastic stroma with variable tubular formation and only mild focal inflammation. | D | TCGA-E2-A105 | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-E2-A105-01Z-00-DX1.192813F9-2D7B-40C7-88D9-BFA939D43FEE.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A105/1.3.6.1.4.1.14519.5.2.1.3023.4002.764533775161819961703293521534/1.3.6.1.4.1.14519.5.2.1.3023.4002.189863101020484121418565300460",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A105-01A__8bc28a3e-1497-40f4-a231-486b76e4a280.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A105__2e60bad2-2dd2-4dc3-aa45-dfc36ef4884b.pt | |||||
TCGA-E2-A105 | TCGA-BRCA | 9,061,606,812,857,741,000 | 8,794,444,376,126,706,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | CDH1 truncation with PIK3CA E542K plus ARID1A and NF1 loss; copy-number quiet LumA, ESR1/PGR/FOXA1/GATA3 expressing. | LumA with ESR1/PGR/FOXA1/GATA3 expression; ER low/PR high/HER2 low concordance; high ESR1 and BRCA1 promoter methylation. | Luminal lineage with HER2-low surrogate, low HRD, high ESR1 methylation, and mixed LumA registry versus LumB RNA calls. | NCOR1 missense only; LumB with high ESR1/GATA3, lower PGR, high ERBB2 transcripts; copy-number neutral, HRD-low. | Luminal lineage with HER2-low surrogate, low HRD, high ESR1 methylation, and mixed LumA registry versus LumB RNA calls. | C | TCGA-E2-A105 | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-E2-A105-01Z-00-DX1.192813F9-2D7B-40C7-88D9-BFA939D43FEE.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A105/1.3.6.1.4.1.14519.5.2.1.3023.4002.764533775161819961703293521534/1.3.6.1.4.1.14519.5.2.1.3023.4002.189863101020484121418565300460",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A105-01A__8bc28a3e-1497-40f4-a231-486b76e4a280.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A105__2e60bad2-2dd2-4dc3-aa45-dfc36ef4884b.pt | |||||
TCGA-E2-A105 | TCGA-BRCA | 4,337,729,317,879,684,000 | 1,544,194,365,173,289,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Necrosis-rich solid/nested invasive carcinoma paired with hotspot PIK3CA-H1047R and TP53 defines a distinct PI3K-activated, copy-number-stable profile. | TP53-driven invasive ductal-type carcinoma lacking luminal-pathway mutations or major copy-number events, with discordant basal versus HER2-enriched biology. | Luminal B yet proliferative invasive ductal carcinoma combining mixed tubular-solid morphology with isolated TP53 mutation in HR-proficient-like genomically quiet background. | Infiltrative gland-forming carcinoma with adipose extension paired with irregular septated MRI enhancement and luminal ER-lineage biology. | Infiltrative gland-forming carcinoma with adipose extension paired with irregular septated MRI enhancement and luminal ER-lineage biology. | D | TCGA-E2-A105 | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-E2-A105-01Z-00-DX1.192813F9-2D7B-40C7-88D9-BFA939D43FEE.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A105/1.3.6.1.4.1.14519.5.2.1.3023.4002.764533775161819961703293521534/1.3.6.1.4.1.14519.5.2.1.3023.4002.189863101020484121418565300460",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A105-01A__8bc28a3e-1497-40f4-a231-486b76e4a280.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A105__2e60bad2-2dd2-4dc3-aa45-dfc36ef4884b.pt | |||||
TCGA-E2-A10F | TCGA-BRCA | 7,777,576,900,271,554,000 | 4,233,219,973,307,017,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Broad nonuniform hyperintense breast region with patchy-confluent enhancement and separate lower-lateral enhancing nodular focus suggesting multifocal lesion complex. | Irregular heterogeneous enhancing focus with adjacent linear or branching non-mass enhancement extending through nearby breast tissue. | Irregular enhancing focus with internal heterogeneity and adjacent linear/spiculated extensions in surrounding fibroglandular tissue. | Localized ill-defined heterogeneous breast parenchymal lesion with mild linear streak-like internal texture on limited sagittal MRI slices. | Irregular enhancing focus with internal heterogeneity and adjacent linear/spiculated extensions in surrounding fibroglandular tissue. | C | TCGA-E2-A10F | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-E2-A10F-01Z-00-DX1.18F9324C-A38F-478E-95DF-B8E172D0DD07.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A10F/1.3.6.1.4.1.14519.5.2.1.3023.4002.116673044602487525361511216473/1.3.6.1.4.1.14519.5.2.1.3023.4002.171437138732890431625706451049",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A10F-01A__3d0783d1-66cd-48b0-a524-e80dabefd318.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A10F__a7d3a4c0-36ee-43ff-bdcc-37db4b11df76.pt | |||||
TCGA-E2-A10F | TCGA-BRCA | 7,205,557,312,275,329,000 | 7,816,537,361,467,125,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Stellate streaming invasion with irregular angulated tubules, cords, and small nests extending into adipose; patchy lymphoid aggregates; no necrosis. | Discohesive infiltrative carcinoma with small nests, linear cords, single-cell infiltration, stromal hyalinization, and adipose extension. | Fused and cribriform glands with focal solid nests at fibrofatty interface in prominent desmoplastic stroma; only mild scattered chronic inflammation. | Predominantly papillary carcinoma with arborizing fibrovascular fronds, intraluminal papillae, cribriform-tubular fusion, and angulated invasive glands in desmoplastic stroma. | Discohesive infiltrative carcinoma with small nests, linear cords, single-cell infiltration, stromal hyalinization, and adipose extension. | B | TCGA-E2-A10F | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-E2-A10F-01Z-00-DX1.18F9324C-A38F-478E-95DF-B8E172D0DD07.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A10F/1.3.6.1.4.1.14519.5.2.1.3023.4002.116673044602487525361511216473/1.3.6.1.4.1.14519.5.2.1.3023.4002.171437138732890431625706451049",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A10F-01A__3d0783d1-66cd-48b0-a524-e80dabefd318.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A10F__a7d3a4c0-36ee-43ff-bdcc-37db4b11df76.pt | |||||
TCGA-E2-A10F | TCGA-BRCA | 3,791,234,233,527,448,000 | 8,895,591,730,358,269,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | Genomically quiet luminal tumor with ESR1 and BRCA1 promoter hypermethylation, wild-type CDH1, and mixed LumA/LumB labels. | Dual truncating MAP3K1 loss with LumA profile: ESR1/PGR/FOXA1/GATA3-high, MKI67-low, ER-high/PR-high/HER2-low, genomically quiet. | LumA with ESR1/PGR/FOXA1/GATA3 expression, high ESR1 methylation, intermediate BRCA1/GSTP1 methylation, low HRD signal. | PIK3CA E545K; LumA with high ESR1/PGR/FOXA1/GATA3, low HER2 surrogacy, wild-type TP53/CDH1, low TMB 0.76, HRD 4. | LumA with ESR1/PGR/FOXA1/GATA3 expression, high ESR1 methylation, intermediate BRCA1/GSTP1 methylation, low HRD signal. | C | TCGA-E2-A10F | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-E2-A10F-01Z-00-DX1.18F9324C-A38F-478E-95DF-B8E172D0DD07.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A10F/1.3.6.1.4.1.14519.5.2.1.3023.4002.116673044602487525361511216473/1.3.6.1.4.1.14519.5.2.1.3023.4002.171437138732890431625706451049",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A10F-01A__3d0783d1-66cd-48b0-a524-e80dabefd318.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A10F__a7d3a4c0-36ee-43ff-bdcc-37db4b11df76.pt | |||||
TCGA-E2-A10F | TCGA-BRCA | 9,176,839,714,618,718,000 | 7,993,402,547,698,936,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Solid ductal-pattern carcinoma with lymphocyte-rich desmoplastic stroma concordant with basal-like, TP53-disrupted, copy-number-quiet biology. | Immune-rich poorly differentiated non-luminal breast carcinoma, TP53-driven, lacking HRD and classic luminal pathway alterations. | Desmoplastic invasive gland-forming carcinoma with MRI heterogeneity and distinctive PIK3CA-driven luminal A, copy-number-quiet biology. | Lobular-context invasive carcinoma showing discohesive stromal and fat invasion, supported by luminal A hormone-lineage biology. | Lobular-context invasive carcinoma showing discohesive stromal and fat invasion, supported by luminal A hormone-lineage biology. | D | TCGA-E2-A10F | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-E2-A10F-01Z-00-DX1.18F9324C-A38F-478E-95DF-B8E172D0DD07.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A10F/1.3.6.1.4.1.14519.5.2.1.3023.4002.116673044602487525361511216473/1.3.6.1.4.1.14519.5.2.1.3023.4002.171437138732890431625706451049",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A10F-01A__3d0783d1-66cd-48b0-a524-e80dabefd318.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A10F__a7d3a4c0-36ee-43ff-bdcc-37db4b11df76.pt | |||||
TCGA-E2-A14Q | TCGA-BRCA | 5,292,036,845,754,163,000 | 6,681,411,474,339,846,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Irregular nonmass-like ill-defined enhancing focus in fibroglandular tissue along the chest wall side, with internal heterogeneity. | Broader regional irregular heterogeneous enhancement with ill-defined to spiculated interface, beyond the smaller central ROI. | Irregular heterogeneous focal breast mass with adjacent linear/trabecular distortion, more mass-like than subtle nonmass abnormalities. | Irregular heterogeneously hyperintense mass with clustered nonuniform internal enhancement; possible adjacent separate parenchymal enhancing focus. | Irregular heterogeneous focal breast mass with adjacent linear/trabecular distortion, more mass-like than subtle nonmass abnormalities. | C | TCGA-E2-A14Q | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-E2-A14Q-01Z-00-DX1.C19BA7FD-D986-4E3B-9A79-F3531A78F05D.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A14Q/1.3.6.1.4.1.14519.5.2.1.3023.4002.187651268074380888847873982666/1.3.6.1.4.1.14519.5.2.1.3023.4002.192224565510150977734012619405",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A14Q-01A__61a0299a-d092-4486-8121-076c86c3d1d1.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A14Q__a03952ab-2ac1-43a5-a438-1f022bcd0b16.pt | |||||
TCGA-E2-A14Q | TCGA-BRCA | 682,486,921,610,042,500 | 5,955,272,551,541,882,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Cellular invasive carcinoma with irregular nests, solid-trabecular islands, cribriform/glandular heterogeneity, stromal hyalinization, and patchy peritumoral inflammation. | Mixed nests, cords, glands, and cribriform/papillary spaces in desmoplastic stroma, with central luminal debris/necrotic material. | Predominantly solid broad-sheet architecture with pushing-to-infiltrative borders, minimal tubules, focal hemorrhage, and geographic stromal separation/fragmentation. | Haphazard small angulated glands, tubules, and cords in dense collagenized desmoplasia with limited inflammation and adipose invasion. | Mixed nests, cords, glands, and cribriform/papillary spaces in desmoplastic stroma, with central luminal debris/necrotic material. | B | TCGA-E2-A14Q | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-E2-A14Q-01Z-00-DX1.C19BA7FD-D986-4E3B-9A79-F3531A78F05D.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A14Q/1.3.6.1.4.1.14519.5.2.1.3023.4002.187651268074380888847873982666/1.3.6.1.4.1.14519.5.2.1.3023.4002.192224565510150977734012619405",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A14Q-01A__61a0299a-d092-4486-8121-076c86c3d1d1.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A14Q__a03952ab-2ac1-43a5-a438-1f022bcd0b16.pt | |||||
TCGA-E2-A14Q | TCGA-BRCA | 5,468,989,757,036,284,000 | 1,106,378,651,853,763,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | Genomically silent LumA: no panel mutations or copy-number changes, TMB 0.95, high ESR1/FOXA1/GATA3, high BRCA1/ESR1 methylation. | Mutation- and copy-number–silent LumA tumor with high ESR1, PGR, FOXA1, GATA3 expression and very low TMB. | PIK3CA p.H1047R hotspot plus in-frame TP53 alteration; copy-number neutral, no rearrangements; ERBB2 expression with mixed HER2-enriched/luminal-B signals. | PIK3CA E542K-mutant LumB profile with high ESR1, lower PR than ER, and otherwise copy-number-silent genome. | Mutation- and copy-number–silent LumA tumor with high ESR1, PGR, FOXA1, GATA3 expression and very low TMB. | B | TCGA-E2-A14Q | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-E2-A14Q-01Z-00-DX1.C19BA7FD-D986-4E3B-9A79-F3531A78F05D.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A14Q/1.3.6.1.4.1.14519.5.2.1.3023.4002.187651268074380888847873982666/1.3.6.1.4.1.14519.5.2.1.3023.4002.192224565510150977734012619405",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A14Q-01A__61a0299a-d092-4486-8121-076c86c3d1d1.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A14Q__a03952ab-2ac1-43a5-a438-1f022bcd0b16.pt | |||||
TCGA-E2-A14Q | TCGA-BRCA | 2,493,006,540,034,100,000 | 9,025,532,282,256,850,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Male LumB ductal-pattern carcinoma showing preserved ER-lineage signaling without genomic-instability features, aligning invasive morphology with luminal biology. | Genomically quiet hormone-driven LumA carcinoma paired with architecturally heterogeneous infiltrative gland-forming/nested histology and suspicious irregular mass distortion. | Localized posterior breast lesion with regional nonmass complexity aligns with genomically quiet luminal tumor driven by PIK3CA/GATA3-pathway alterations. | Localized right breast mass with possible small separate ipsilateral lateral/axillary-adjacent focus and genomically quiet luminal tumor driven by ARID1A loss. | Genomically quiet hormone-driven LumA carcinoma paired with architecturally heterogeneous infiltrative gland-forming/nested histology and suspicious irregular mass distortion. | B | TCGA-E2-A14Q | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-E2-A14Q-01Z-00-DX1.C19BA7FD-D986-4E3B-9A79-F3531A78F05D.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A14Q/1.3.6.1.4.1.14519.5.2.1.3023.4002.187651268074380888847873982666/1.3.6.1.4.1.14519.5.2.1.3023.4002.192224565510150977734012619405",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A14Q-01A__61a0299a-d092-4486-8121-076c86c3d1d1.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A14Q__a03952ab-2ac1-43a5-a438-1f022bcd0b16.pt | |||||
TCGA-E2-A14V | TCGA-BRCA | 8,781,724,602,038,080,000 | 4,632,925,834,801,233,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Small rounded to mildly lobulated enhancing intraparenchymal breast focus amid diffuse background parenchymal enhancement. | Small focal enhancing breast mass with irregular non-circumscribed contours, appearing localized rather than multifocal or nodal-associated. | Irregular heterogeneously enhancing lesion centered upper-central posterior parenchyma, abutting posterior breast/chest wall interface. | Broader regional irregular heterogeneous enhancement with ill-defined to spiculated interface, beyond the smaller central ROI. | Broader regional irregular heterogeneous enhancement with ill-defined to spiculated interface, beyond the smaller central ROI. | D | TCGA-E2-A14V | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-E2-A14V-01Z-00-DX1.D6274B5E-644C-478C-817F-B8BB9262D6F4.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A14V/1.3.6.1.4.1.14519.5.2.1.3023.4002.302583082328316561806050038155/1.3.6.1.4.1.14519.5.2.1.3023.4002.104345019676551465028332380747",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A14V-01A__76718f7f-3a82-489c-8a56-f2cd57a5dd86.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A14V__7efb7266-28ee-41d3-912a-b0f67135216f.pt | |||||
TCGA-E2-A14V | TCGA-BRCA | 8,373,113,006,648,407,000 | 1,313,190,153,538,070,500 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Predominantly small irregular angulated glands and compressed tubules in abundant fibrosclerotic stroma, with focal discohesive nests and scant inflammation. | Irregular nests, cords, and angulated glands in desmoplastic stroma with extension into adipose tissue. | Small angulated tubules and cords infiltrate markedly desmoplastic collagen with adipose interface invasion; sampled regions differ mainly by stromal density. | Heterogeneous infiltrative carcinoma with irregular glands, nests, trabeculae, focal solid areas, and luminal spaces in desmoplastic stroma. | Irregular nests, cords, and angulated glands in desmoplastic stroma with extension into adipose tissue. | B | TCGA-E2-A14V | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-E2-A14V-01Z-00-DX1.D6274B5E-644C-478C-817F-B8BB9262D6F4.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A14V/1.3.6.1.4.1.14519.5.2.1.3023.4002.302583082328316561806050038155/1.3.6.1.4.1.14519.5.2.1.3023.4002.104345019676551465028332380747",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A14V-01A__76718f7f-3a82-489c-8a56-f2cd57a5dd86.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A14V__7efb7266-28ee-41d3-912a-b0f67135216f.pt | |||||
TCGA-E2-A14V | TCGA-BRCA | 6,532,000,244,849,079,000 | 8,637,452,155,606,157,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | TP53 p.Q136P with HER2-enriched transcriptome, very high ERBB2, low ESR1/PGR, copy-number neutral, low TMB, HR-proficient-like. | PIK3CA missense plus truncating GATA3 and NCOR1 alterations; strong ESR1/PGR/FOXA1/GATA3 expression; LumA; copy-number quiet. | Isolated inactivating CDH1 alteration with TP53/PIK3CA wild type; low-TMB, low-HRD genomically quiet LumA profile. | PIK3CA p.N1044Y mutation; strong ERBB2 transcript expression with ESR1, PGR, FOXA1, and GATA3 luminal markers. | PIK3CA p.N1044Y mutation; strong ERBB2 transcript expression with ESR1, PGR, FOXA1, and GATA3 luminal markers. | D | TCGA-E2-A14V | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-E2-A14V-01Z-00-DX1.D6274B5E-644C-478C-817F-B8BB9262D6F4.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A14V/1.3.6.1.4.1.14519.5.2.1.3023.4002.302583082328316561806050038155/1.3.6.1.4.1.14519.5.2.1.3023.4002.104345019676551465028332380747",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A14V-01A__76718f7f-3a82-489c-8a56-f2cd57a5dd86.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A14V__7efb7266-28ee-41d3-912a-b0f67135216f.pt | |||||
TCGA-E2-A14V | TCGA-BRCA | 2,952,579,376,513,557,000 | 9,102,032,520,396,252,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Localized spiculated enhancing lesion matches adipose-invasive desmoplastic carcinoma driven by PI3K activation in a luminal/HER2-related expression context. | Infiltrative gland-forming carcinoma shows luminal B biology despite mutation- and copy-number-quiet DNA profile. | CDH1-inactivated luminal lobular-pattern carcinoma showing invasive fibroadipose extension with targetoid architecture and minimal additional genomic complexity. | Conventional duct-forming morphology aligns with a genomically low-complexity LumA phenotype lacking surveyed drivers or chromosomal instability. | Localized spiculated enhancing lesion matches adipose-invasive desmoplastic carcinoma driven by PI3K activation in a luminal/HER2-related expression context. | A | TCGA-E2-A14V | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-E2-A14V-01Z-00-DX1.D6274B5E-644C-478C-817F-B8BB9262D6F4.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A14V/1.3.6.1.4.1.14519.5.2.1.3023.4002.302583082328316561806050038155/1.3.6.1.4.1.14519.5.2.1.3023.4002.104345019676551465028332380747",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A14V-01A__76718f7f-3a82-489c-8a56-f2cd57a5dd86.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A14V__7efb7266-28ee-41d3-912a-b0f67135216f.pt | |||||
TCGA-E2-A15F | TCGA-BRCA | 459,645,844,122,117,000 | 5,298,690,395,628,899,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Upper-central breast irregular heterogeneous enhancing mass with adjacent small enhancing foci or contiguous extension. | Irregular spiculated soft-tissue breast mass with radiating linear extensions and internal heterogeneity. | Irregular heterogeneous enhancing mass with central nonenhancing spaces and partially rim-like appearance, suggesting internal necrotic or cystic change. | Irregular non-circumscribed heterogeneous enhancing mass extends posteriorly toward the chest wall interface. | Irregular spiculated soft-tissue breast mass with radiating linear extensions and internal heterogeneity. | B | TCGA-E2-A15F | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-E2-A15F-01Z-00-DX1.F022214A-3F0C-4DA4-A0EE-735D27480A45.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A15F/1.3.6.1.4.1.14519.5.2.1.3023.4002.156518929897606479015192108560/1.3.6.1.4.1.14519.5.2.1.3023.4002.141397052282233210972951890215",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A15F-01A__29b2336c-acc2-44f9-a450-d5a01f80f4d6.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A15F__15e249cf-4c45-4006-84fd-899f9927e376.pt | |||||
TCGA-E2-A15F | TCGA-BRCA | 1,282,947,332,900,626,000 | 925,424,033,794,531,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Dispersed cords and linear single-cell arrays in desmoplastic stroma, extending into adjacent adipose tissue with patchy chronic inflammation. | Labyrinthine irregular glands, tubules, and elongated nests with focal solid areas entrapped in dense desmoplastic stroma. | Irregular angulated tubules with small nests and cords infiltrate desmoplastic stroma and adipocytes; patchy chronic inflammation. | Discohesive low-cellularity carcinoma infiltrates desmoplastic stroma in thin cords and single-file arrays with patchy chronic stromal inflammation. | Irregular angulated tubules with small nests and cords infiltrate desmoplastic stroma and adipocytes; patchy chronic inflammation. | C | TCGA-E2-A15F | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-E2-A15F-01Z-00-DX1.F022214A-3F0C-4DA4-A0EE-735D27480A45.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A15F/1.3.6.1.4.1.14519.5.2.1.3023.4002.156518929897606479015192108560/1.3.6.1.4.1.14519.5.2.1.3023.4002.141397052282233210972951890215",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A15F-01A__29b2336c-acc2-44f9-a450-d5a01f80f4d6.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A15F__15e249cf-4c45-4006-84fd-899f9927e376.pt | |||||
TCGA-E2-A15F | TCGA-BRCA | 2,201,904,758,848,874,200 | 3,783,096,094,071,362,600 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | Basal-like subtype with very low ESR1/PGR, low HER2 surrogate labeling, elevated MKI67, MYC-target and G2M checkpoint enrichment, aneuploidy. | LumA profile with high ESR1, PGR, FOXA1, GATA3 and low HER2 signal; no specific driver alteration detected. | TP53 splice-site loss; no PIK3CA/GATA3/CDH1/AKT1/PTEN/RB1 alterations; copy-number silent genome; low ESR1/PGR with measurable ERBB2; Basal/HER2-enriched discordance. | Dual-hit TP53 inactivation: p.R175H plus frameshift, copy-number quiet, low TMB, HR-proficient-like, registry basal despite preserved ESR1/PGR/FOXA1/GATA3. | LumA profile with high ESR1, PGR, FOXA1, GATA3 and low HER2 signal; no specific driver alteration detected. | B | TCGA-E2-A15F | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-E2-A15F-01Z-00-DX1.F022214A-3F0C-4DA4-A0EE-735D27480A45.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A15F/1.3.6.1.4.1.14519.5.2.1.3023.4002.156518929897606479015192108560/1.3.6.1.4.1.14519.5.2.1.3023.4002.141397052282233210972951890215",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A15F-01A__29b2336c-acc2-44f9-a450-d5a01f80f4d6.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A15F__15e249cf-4c45-4006-84fd-899f9927e376.pt | |||||
TCGA-E2-A15F | TCGA-BRCA | 479,302,253,318,212,500 | 5,998,986,585,160,830,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Duct-forming invasive carcinoma in desmoplastic stroma with luminal B program driven by activating PIK3CA and minimal genomic complexity. | Stellate infiltrative imaging and tubulocord architecture align with hormone receptor–associated luminal A invasive breast carcinoma. | Imaging-pathology concordant invasive fibrotic mass; genomics uniquely indicates LumB biology with PI3K activation plus RB1/RUNX1 loss. | Invasive carcinoma uniquely coupling inflammatory solid-poorly differentiated morphology with basal transcriptional program and TP53 loss, despite copy-number quietness. | Stellate infiltrative imaging and tubulocord architecture align with hormone receptor–associated luminal A invasive breast carcinoma. | B | TCGA-E2-A15F | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-E2-A15F-01Z-00-DX1.F022214A-3F0C-4DA4-A0EE-735D27480A45.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A15F/1.3.6.1.4.1.14519.5.2.1.3023.4002.156518929897606479015192108560/1.3.6.1.4.1.14519.5.2.1.3023.4002.141397052282233210972951890215",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A15F-01A__29b2336c-acc2-44f9-a450-d5a01f80f4d6.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A15F__15e249cf-4c45-4006-84fd-899f9927e376.pt | |||||
TCGA-E2-A15K | TCGA-BRCA | 283,775,810,070,053,570 | 9,012,277,611,064,517,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Irregular focal parenchymal lesion with indistinct margins and a brighter peripheral focus within fibroglandular tissue. | Bilateral retropectoral implants; dominant posterior lesion abuts implant margin and chest wall with irregular spiculated heterogeneous enhancement. | Subtle ROI-localized solid intraparenchymal lesion within fibroglandular tissue, mildly heterogeneous and lacking a clearly circumscribed capsule. | Irregular hyperintense enhancing breast mass with internal heterogeneity and a conspicuous bright enhancing focus. | Subtle ROI-localized solid intraparenchymal lesion within fibroglandular tissue, mildly heterogeneous and lacking a clearly circumscribed capsule. | C | TCGA-E2-A15K | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-E2-A15K-01Z-00-DX1.9F424BE2-9BFE-4DFF-8CC9-10D2DADBBEA7.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A15K/1.3.6.1.4.1.14519.5.2.1.3023.4002.320641257513307144515804917072/1.3.6.1.4.1.14519.5.2.1.3023.4002.187303405805001679551660711468",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A15K-01A__681a81fd-a7dc-4f23-9ae4-36dab0cf0dfb.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A15K__e0ec172b-4ad3-43a5-aa90-6d64ebca1a76.pt | |||||
TCGA-E2-A15K | TCGA-BRCA | 8,839,495,625,904,272,000 | 3,024,828,870,020,314,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Diffuse to vaguely nested discohesive cells in fibrous, focally hyalinized stroma with pale sclerotic zones and only patchy chronic inflammation. | Infiltrative small angulated gland-forming nests in desmoplastic stroma with brisk nodular lymphoid infiltrates and focal acellular hyalinized/necrotic zone. | Slender single-file cords and discohesive small nests infiltrate fibroadipose tissue within conspicuously desmoplastic stroma. | Irregular nests, cords, and small angulated glands in desmoplastic-fibrosclerotic stroma with prominent chronic inflammation and fibrofatty extension. | Irregular nests, cords, and small angulated glands in desmoplastic-fibrosclerotic stroma with prominent chronic inflammation and fibrofatty extension. | D | TCGA-E2-A15K | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-E2-A15K-01Z-00-DX1.9F424BE2-9BFE-4DFF-8CC9-10D2DADBBEA7.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A15K/1.3.6.1.4.1.14519.5.2.1.3023.4002.320641257513307144515804917072/1.3.6.1.4.1.14519.5.2.1.3023.4002.187303405805001679551660711468",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A15K-01A__681a81fd-a7dc-4f23-9ae4-36dab0cf0dfb.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A15K__e0ec172b-4ad3-43a5-aa90-6d64ebca1a76.pt | |||||
TCGA-E2-A15K | TCGA-BRCA | 2,677,669,758,715,402,000 | 7,493,743,130,734,929,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | Truncating CDH1 frameshift with strong ESR1/PGR expression, luminal phenotype, copy-number quiet genome, low TMB 0.82/Mb, HRD 4. | PIK3CA missense plus truncating GATA3 and NCOR1 alterations; strong ESR1/PGR/FOXA1/GATA3 expression; LumA; copy-number quiet. | PIK3CA p.H1047R hotspot; LumB with high ESR1, lower PR, high BRCA1 and ESR1 promoter methylation, otherwise genomically quiet. | PIK3CA H1047R with CDH1 missense alteration; TP53 wild type; hormone-lineage expression; mixed LumA/Normal-like calls; genomically quiet. | PIK3CA p.H1047R hotspot; LumB with high ESR1, lower PR, high BRCA1 and ESR1 promoter methylation, otherwise genomically quiet. | C | TCGA-E2-A15K | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-E2-A15K-01Z-00-DX1.9F424BE2-9BFE-4DFF-8CC9-10D2DADBBEA7.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A15K/1.3.6.1.4.1.14519.5.2.1.3023.4002.320641257513307144515804917072/1.3.6.1.4.1.14519.5.2.1.3023.4002.187303405805001679551660711468",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A15K-01A__681a81fd-a7dc-4f23-9ae4-36dab0cf0dfb.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A15K__e0ec172b-4ad3-43a5-aa90-6d64ebca1a76.pt | |||||
TCGA-E2-A15K | TCGA-BRCA | 7,388,749,212,630,610,000 | 1,033,589,828,118,291,100 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Invasive stromal-infiltrating luminal breast carcinoma defined by desmoplastic fibrofatty invasion, inflammatory background, and PIK3CA-driven LumB signaling. | Genomically quiet hormone-driven LumA carcinoma paired with architecturally heterogeneous infiltrative gland-forming/nested histology and suspicious irregular mass distortion. | Hormone-lineage but non-HRD, non-fusion-driven breast tumor with prominent stromal and immune admixture lacking subtype-defining driver alteration. | Ductal/NST invasive carcinoma with adipose extension, showing concordant luminal biology despite exceptionally genomically quiet profile. | Invasive stromal-infiltrating luminal breast carcinoma defined by desmoplastic fibrofatty invasion, inflammatory background, and PIK3CA-driven LumB signaling. | A | TCGA-E2-A15K | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-E2-A15K-01Z-00-DX1.9F424BE2-9BFE-4DFF-8CC9-10D2DADBBEA7.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A15K/1.3.6.1.4.1.14519.5.2.1.3023.4002.320641257513307144515804917072/1.3.6.1.4.1.14519.5.2.1.3023.4002.187303405805001679551660711468",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A15K-01A__681a81fd-a7dc-4f23-9ae4-36dab0cf0dfb.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A15K__e0ec172b-4ad3-43a5-aa90-6d64ebca1a76.pt | |||||
TCGA-E2-A1B5 | TCGA-BRCA | 5,644,297,003,626,672,000 | 6,607,134,616,006,570,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | false | true | Which radiology finding best matches this case? | Irregular geographically heterogeneous nonmass enhancement spanning adjacent MRI slices, with patchy confluent high signal and indistinct infiltrative margins. | Single suspicious breast mass with irregular heterogeneous enhancement and patchy marked hyperintensity within enhancing parenchyma. | Broad central heterogeneous intramammary region with internal linear-branching structures, lacking a discrete circumscribed enhancing mass. | Broad subareolar-anterior irregular enhancing lesion with heterogeneous internal texture and no discrete cystic or necrotic component. | Broad subareolar-anterior irregular enhancing lesion with heterogeneous internal texture and no discrete cystic or necrotic component. | D | TCGA-E2-A1B5 | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-E2-A1B5-01Z-00-DX1.AB19FF3D-5C42-4D49-ABEA-D2315709B6EA.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A1B5/1.3.6.1.4.1.14519.5.2.1.3023.4002.129150419527303352793024198814/1.3.6.1.4.1.14519.5.2.1.3023.4002.289737997463011453680799713427",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A1B5__2cd221ee-4d29-4f40-ab4c-780cc9045c5a.pt | ||||||
TCGA-E2-A1B5 | TCGA-BRCA | 7,087,701,588,507,972,000 | 7,409,913,946,892,037,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | false | true | Which pathology finding best matches this case? | Diffuse vaguely nested solid sheets with expansile nodules in desmoplastic stroma, scant tubules, no necrosis, mild-moderate peripheral lymphoid infiltrate. | Angulated tubules, nests, and cords in densely collagenized desmoplastic stroma with tumor in a vascular space. | Single-file linear arrays and loose cords of tumor cells in desmoplastic stroma, infiltrating collagenized tissue and approaching adipose. | High-cellularity infiltrative carcinoma in fibroadipose tissue with elongated cords, patchy stromal separation, and densely collagenized desmoplastic stroma. | Single-file linear arrays and loose cords of tumor cells in desmoplastic stroma, infiltrating collagenized tissue and approaching adipose. | C | TCGA-E2-A1B5 | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-E2-A1B5-01Z-00-DX1.AB19FF3D-5C42-4D49-ABEA-D2315709B6EA.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A1B5/1.3.6.1.4.1.14519.5.2.1.3023.4002.129150419527303352793024198814/1.3.6.1.4.1.14519.5.2.1.3023.4002.289737997463011453680799713427",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A1B5__2cd221ee-4d29-4f40-ab4c-780cc9045c5a.pt | ||||||
TCGA-E2-A1B5 | TCGA-BRCA | 6,186,152,990,727,955,000 | 4,197,914,607,594,548,700 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | false | true | Which genomic finding best matches this case? | TP53 p.P151H basal-like, low ESR1/PGR, low HER2, enriched MYC-target, EMT, UPR, interferon-gamma; copy-number neutral; low HRD/TMB. | GATA3 frameshift-mutant, CDH1-wildtype, copy-number-silent LumA tumor with low TMB and low HRD. | PIK3CA H1047R hotspot with LumB subtype; ESR1/PGR/FOXA1/GATA3 expressed; copy-number neutral, very low TMB and HRD. | Truncating CDH1 alteration with LumB profile, high ESR1, lower PGR, HER2-low signaling, measurable proliferation, HR-proficient-like low-CNA genome. | GATA3 frameshift-mutant, CDH1-wildtype, copy-number-silent LumA tumor with low TMB and low HRD. | B | TCGA-E2-A1B5 | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-E2-A1B5-01Z-00-DX1.AB19FF3D-5C42-4D49-ABEA-D2315709B6EA.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A1B5/1.3.6.1.4.1.14519.5.2.1.3023.4002.129150419527303352793024198814/1.3.6.1.4.1.14519.5.2.1.3023.4002.289737997463011453680799713427",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A1B5__2cd221ee-4d29-4f40-ab4c-780cc9045c5a.pt | ||||||
TCGA-E2-A1B5 | TCGA-BRCA | 8,456,710,749,561,598,000 | 8,353,499,191,455,289,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | false | true | Which integrated interpretation best matches this case? | Lobular-leaning invasive carcinoma with brisk stromal lymphoid aggregates and exceptionally low-complexity luminal molecular profile. | Lobular-pattern infiltrative morphology aligns with noncircumscribed subareolar lesion; genomics uniquely shows luminal, genomically quiet GATA3-altered biology. | Non-luminal-leaning invasive carcinoma with TP53 loss, immune-associated biology, and inflamed desmoplastic histology in a left upper-outer enhancing lesion. | Heterogeneous focal breast malignancy with biologically aggressive basal-like TP53-mutant profile, contrasting luminal PIK3CA-driven comparators. | Lobular-pattern infiltrative morphology aligns with noncircumscribed subareolar lesion; genomics uniquely shows luminal, genomically quiet GATA3-altered biology. | B | TCGA-E2-A1B5 | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-E2-A1B5-01Z-00-DX1.AB19FF3D-5C42-4D49-ABEA-D2315709B6EA.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk8/pngs/TCGA-BRCA/TCGA-E2-A1B5/1.3.6.1.4.1.14519.5.2.1.3023.4002.129150419527303352793024198814/1.3.6.1.4.1.14519.5.2.1.3023.4002.289737997463011453680799713427",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A1B5__2cd221ee-4d29-4f40-ab4c-780cc9045c5a.pt | ||||||
TCGA-E2-A1II | TCGA-BRCA | 1,994,485,726,384,811,000 | 6,519,703,627,780,970,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | false | true | Which radiology finding best matches this case? | Irregular asymmetric tissue signal at posterior-to-central breast/parenchymal interface near chest wall, on sampled unilateral MRI slices. | Irregular non-circumscribed solid lesion with internal heterogeneity and smaller nested internal focus within broader abnormal parenchymal change. | Ill-defined right posterior breast lesion with irregular internal signal and nonmass-like extension abutting retromammary/chest wall interface. | Left-sided irregular enhancing mass with spiculated radiating margins and infiltrative appearance in breast parenchyma. | Irregular non-circumscribed solid lesion with internal heterogeneity and smaller nested internal focus within broader abnormal parenchymal change. | B | TCGA-E2-A1II | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-E2-A1II-01Z-00-DX1.7F782477-0F92-4C57-8735-A1E3F95A6B94.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk9/pngs/TCGA-BRCA/TCGA-E2-A1II/1.3.6.1.4.1.14519.5.2.1.3023.4002.220775880359213884547946541862/1.3.6.1.4.1.14519.5.2.1.3023.4002.106482406493514983292994829989",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A1II__b9220098-f6f9-4732-8e94-3c9eeb4b8479.pt | ||||||
TCGA-E2-A1II | TCGA-BRCA | 6,701,955,262,260,620,000 | 8,174,663,829,679,931,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | false | true | Which pathology finding best matches this case? | Predominantly papillary carcinoma with arborizing fibrovascular fronds, intraluminal papillae, cribriform-tubular fusion, and angulated invasive glands in desmoplastic stroma. | Predominantly irregular angulated tubules and small glands in abundant desmoplastic stroma, infiltrating around adipose tissue. | Whorled desmoplastic fibrosis entrapping sparse small glands and residual ducts, with crowded rounded glands in dense collagen and patchy chronic inflammation. | Solid-vaguely trabecular invasive nests in fibroadipose tissue with conspicuous lymphoid infiltrate and broad peripheral necrotic debris. | Solid-vaguely trabecular invasive nests in fibroadipose tissue with conspicuous lymphoid infiltrate and broad peripheral necrotic debris. | D | TCGA-E2-A1II | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-E2-A1II-01Z-00-DX1.7F782477-0F92-4C57-8735-A1E3F95A6B94.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk9/pngs/TCGA-BRCA/TCGA-E2-A1II/1.3.6.1.4.1.14519.5.2.1.3023.4002.220775880359213884547946541862/1.3.6.1.4.1.14519.5.2.1.3023.4002.106482406493514983292994829989",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A1II__b9220098-f6f9-4732-8e94-3c9eeb4b8479.pt | ||||||
TCGA-E2-A1II | TCGA-BRCA | 301,640,090,897,378,100 | 352,127,324,883,567,740 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | false | true | Which genomic finding best matches this case? | GATA3 frameshift with wild-type TP53/PIK3CA/CDH1/AKT1; LumB, high ESR1 low PGR, HER2-low, MKI67/proliferation enrichment, copy-number quiet. | HER2-enriched subtype with high ERBB2, low ESR1/PGR, aneuploid copy-number complexity, high ESR1 methylation, intermediate BRCA1 methylation. | TP53 missense plus MAP2K4 splice-site loss; LumA with high ESR1/FOXA1/GATA3, lower PR, HER2-low, copy-number quiet. | TP53 splice-site loss with basal-like subtype, very low ESR1/PGR, low HER2 signal, enriched MYC-target and interferon-response programs. | TP53 splice-site loss with basal-like subtype, very low ESR1/PGR, low HER2 signal, enriched MYC-target and interferon-response programs. | D | TCGA-E2-A1II | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-E2-A1II-01Z-00-DX1.7F782477-0F92-4C57-8735-A1E3F95A6B94.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk9/pngs/TCGA-BRCA/TCGA-E2-A1II/1.3.6.1.4.1.14519.5.2.1.3023.4002.220775880359213884547946541862/1.3.6.1.4.1.14519.5.2.1.3023.4002.106482406493514983292994829989",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A1II__b9220098-f6f9-4732-8e94-3c9eeb4b8479.pt | ||||||
TCGA-E2-A1II | TCGA-BRCA | 4,702,693,857,839,671,000 | 1,373,129,225,414,051,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | false | true | Which integrated interpretation best matches this case? | Stromal-rich invasive carcinoma with lobular-leaning luminal biology, combining fibroadipose infiltration, dense lymphoid background, CDH1 loss, and PI3K activation. | Compact irregular mass matches invasive stromal-adipose infiltration; lymphoid-rich necrotic histology and basal-like TP53-altered biology distinguish this case. | Localized MRI-enhancing lesion matches desmoplastic gland-forming invasive carcinoma with distinctive luminal PIK3CA/GATA3-altered, copy-number-silent biology. | Discohesive scirrhous invasive phenotype aligns with CDH1-altered, copy-number-quiet luminal-oriented tumor lacking canonical TP53/PTEN or PIK3CA-driven biology. | Compact irregular mass matches invasive stromal-adipose infiltration; lymphoid-rich necrotic histology and basal-like TP53-altered biology distinguish this case. | B | TCGA-E2-A1II | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-E2-A1II-01Z-00-DX1.7F782477-0F92-4C57-8735-A1E3F95A6B94.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk9/pngs/TCGA-BRCA/TCGA-E2-A1II/1.3.6.1.4.1.14519.5.2.1.3023.4002.220775880359213884547946541862/1.3.6.1.4.1.14519.5.2.1.3023.4002.106482406493514983292994829989",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A1II__b9220098-f6f9-4732-8e94-3c9eeb4b8479.pt | ||||||
TCGA-E2-A1L9 | TCGA-BRCA | 8,837,499,761,052,308,000 | 8,447,564,848,586,411,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Heterogeneous non-mass-like infiltrative enhancement with irregular internal linear and trabecular architecture causing parenchymal distortion. | Enhancing irregular intraparenchymal mass with heterogeneous internal signal and interspersed linear-to-confluent brighter components. | Deep central retroareolar irregular heterogeneously enhancing mass with patchy internal enhancement and adjacent bright ipsilateral axillary nodular tissue. | Irregular geographically heterogeneous nonmass enhancement spanning adjacent MRI slices, with patchy confluent high signal and indistinct infiltrative margins. | Enhancing irregular intraparenchymal mass with heterogeneous internal signal and interspersed linear-to-confluent brighter components. | B | TCGA-E2-A1L9 | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-E2-A1L9-01Z-00-DX1.F2CC1036-8EEE-4664-962E-541B8ACB10DE.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk9/pngs/TCGA-BRCA/TCGA-E2-A1L9/1.3.6.1.4.1.14519.5.2.1.3023.4002.182205375858424316455190162542/1.3.6.1.4.1.14519.5.2.1.3023.4002.114601413333398682487018661430",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A1L9-01A__d5d0f08c-c15e-42a0-8c9f-bb4aa32c9ce5.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A1L9__ea01e210-0d45-4c23-8644-904771672188.pt | |||||
TCGA-E2-A1L9 | TCGA-BRCA | 4,477,903,585,654,804,000 | 7,859,800,514,550,481,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Invasive tubule-, nest-, and cord-forming carcinoma in markedly collagenized desmoplastic stroma, extending into adipose tissue. | Predominantly crowded angulated tubules and irregular small glands in conspicuous desmoplastic stroma, with monomorphic cells and minimal inflammation. | Predominantly crowded angulated tubules and small glands with trabeculated duct-forming architecture in abundant desmoplastic stroma. | Dispersed small nests and ill-defined cords in fibroadipose tissue, with rounded densely cellular nodular focus and minimal tubule formation. | Invasive tubule-, nest-, and cord-forming carcinoma in markedly collagenized desmoplastic stroma, extending into adipose tissue. | A | TCGA-E2-A1L9 | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-E2-A1L9-01Z-00-DX1.F2CC1036-8EEE-4664-962E-541B8ACB10DE.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk9/pngs/TCGA-BRCA/TCGA-E2-A1L9/1.3.6.1.4.1.14519.5.2.1.3023.4002.182205375858424316455190162542/1.3.6.1.4.1.14519.5.2.1.3023.4002.114601413333398682487018661430",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A1L9-01A__d5d0f08c-c15e-42a0-8c9f-bb4aa32c9ce5.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A1L9__ea01e210-0d45-4c23-8644-904771672188.pt | |||||
TCGA-E2-A1L9 | TCGA-BRCA | 4,909,930,001,266,184,000 | 8,507,563,884,579,024,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | PIK3CA H1047R with CDH1 missense alteration; TP53 wild type; hormone-lineage expression; mixed LumA/Normal-like calls; genomically quiet. | LumA subtype with high ESR1/GATA3, ER-high PR-low HER2-low signaling, modest aneuploidy, and ESR1/BRCA1 promoter methylation. | AKT1 E17K and truncating GATA3 frameshift with LumA expression; strong ESR1/PGR/FOXA1/GATA3, TP53 wild-type, copy-number quiet. | Activating PIK3CA N345K with TP53/CDH1 wild type, LumA lineage markers, copy-number neutral genome, low TMB 1.24, HRD 12. | AKT1 E17K and truncating GATA3 frameshift with LumA expression; strong ESR1/PGR/FOXA1/GATA3, TP53 wild-type, copy-number quiet. | C | TCGA-E2-A1L9 | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-E2-A1L9-01Z-00-DX1.F2CC1036-8EEE-4664-962E-541B8ACB10DE.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk9/pngs/TCGA-BRCA/TCGA-E2-A1L9/1.3.6.1.4.1.14519.5.2.1.3023.4002.182205375858424316455190162542/1.3.6.1.4.1.14519.5.2.1.3023.4002.114601413333398682487018661430",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A1L9-01A__d5d0f08c-c15e-42a0-8c9f-bb4aa32c9ce5.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A1L9__ea01e210-0d45-4c23-8644-904771672188.pt | |||||
TCGA-E2-A1L9 | TCGA-BRCA | 5,426,508,121,098,398,000 | 5,002,968,243,394,943,000 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Tubule-forming invasive carcinoma with adipose extension and transcriptomic LumA phenotype despite lacking canonical luminal driver alterations. | Metaplastic-appearing poorly differentiated spindle/solid carcinoma with necrosis and inflammation, showing non-luminal receptor-suppressed chromosomally unstable biology. | Lobular luminal carcinoma highlighted by fibroadipose-permeating discohesive growth and the distinctive CDH1-loss plus PIK3CA H1047R combination. | Concordant invasive desmoplastic tubuloglandular breast carcinoma with distinctive luminal A, AKT1/GATA3-mutant, low-burden biology. | Concordant invasive desmoplastic tubuloglandular breast carcinoma with distinctive luminal A, AKT1/GATA3-mutant, low-burden biology. | D | TCGA-E2-A1L9 | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-E2-A1L9-01Z-00-DX1.F2CC1036-8EEE-4664-962E-541B8ACB10DE.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk9/pngs/TCGA-BRCA/TCGA-E2-A1L9/1.3.6.1.4.1.14519.5.2.1.3023.4002.182205375858424316455190162542/1.3.6.1.4.1.14519.5.2.1.3023.4002.114601413333398682487018661430",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-E2-A1L9-01A__d5d0f08c-c15e-42a0-8c9f-bb4aa32c9ce5.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-E2-A1L9__ea01e210-0d45-4c23-8644-904771672188.pt | |||||
TCGA-EW-A1J6 | TCGA-BRCA | 5,332,132,994,951,750,000 | 7,539,266,637,947,852,000 | train | mcq | from_caption | caption_radiology | radiology_findings | all_available | true | true | true | true | Which radiology finding best matches this case? | Stellate spiculated enhancing parenchymal lesion extends toward anterior soft tissues with adjacent linear infiltrative extensions. | Large irregular heterogeneous enhancing mass occupying much of imaged breast parenchyma, with patchy brighter internal foci and partly indistinct lobulated margins. | Dominant irregular stellate-spiculated enhancing mass with surrounding nonmass enhancement and adjacent enhancing linear structures indicating local parenchymal extension. | Unilateral irregular heterogeneous enhancing breast mass with asymmetric focal enhancement amid substantial background parenchymal enhancement. | Stellate spiculated enhancing parenchymal lesion extends toward anterior soft tissues with adjacent linear infiltrative extensions. | A | TCGA-EW-A1J6 | condensed_caption:radiology_findings | [
"data/features/features_uni/TCGA-EW-A1J6-01Z-00-DX1.F668E978-13B6-4284-9522-37C65C57A21A.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk9/pngs/TCGA-BRCA/TCGA-EW-A1J6/1.3.6.1.4.1.14519.5.2.1.1869.4002.108214931724014572767522872903/1.3.6.1.4.1.14519.5.2.1.1869.4002.118850153407444363131902629868",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-EW-A1J6-01A__5d56e68a-eab1-434b-af69-f887eace7502.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-EW-A1J6__d7e1d1f4-3189-401d-91dc-048ab13ce5df.pt | |||||
TCGA-EW-A1J6 | TCGA-BRCA | 5,634,980,547,034,814,000 | 3,589,767,790,650,598,000 | train | mcq | from_caption | caption_pathology | pathology_findings | all_available | true | true | true | true | Which pathology finding best matches this case? | Small-intermediate epithelial cells in thin strands and poorly formed nests invade fibrous stroma and adipose tissue amid diffuse sclerosis. | Lymphocyte-rich solid carcinoma with confluent nests, broad desmoplasia, scant tubules, and geographic pale necrotic-regressive spaces. | Irregular nests and cords in prominent desmoplastic stroma with brisk lymphoid-rich tumor-stroma interface inflammation. | Abundant extracellular pale mucin with floating epithelial clusters and angulated glands; variable cellularity and broad hypocellular mucin pools. | Small-intermediate epithelial cells in thin strands and poorly formed nests invade fibrous stroma and adipose tissue amid diffuse sclerosis. | A | TCGA-EW-A1J6 | condensed_caption:pathology_findings | [
"data/features/features_uni/TCGA-EW-A1J6-01Z-00-DX1.F668E978-13B6-4284-9522-37C65C57A21A.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk9/pngs/TCGA-BRCA/TCGA-EW-A1J6/1.3.6.1.4.1.14519.5.2.1.1869.4002.108214931724014572767522872903/1.3.6.1.4.1.14519.5.2.1.1869.4002.118850153407444363131902629868",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-EW-A1J6-01A__5d56e68a-eab1-434b-af69-f887eace7502.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-EW-A1J6__d7e1d1f4-3189-401d-91dc-048ab13ce5df.pt | |||||
TCGA-EW-A1J6 | TCGA-BRCA | 8,271,276,080,650,121,000 | 8,397,347,575,991,144,000 | train | mcq | from_caption | caption_genomics | genomic_findings | all_available | true | true | true | true | Which genomic finding best matches this case? | No detected driver mutations or copy-number events; ESR1/FOXA1/GATA3-high luminal profile, low TMB, high ESR1 promoter methylation. | No pathogenic mutations or copy-number changes; low TMB/HRD; ESR1-FOXA1-GATA3 high, PR lower, HER2 low; LumA registry, LumB RNA. | Genomically quiet luminal-profile tumor: no panel mutations, copy-number neutral, low TMB, HRD 17 HR-proficient-like, strong ESR1/FOXA1/GATA3 expression. | PIK3CA p.H1047R with otherwise wild-type common drivers; LumA transcriptome preserving ESR1, PGR, FOXA1, GATA3; copy-number silent. | No detected driver mutations or copy-number events; ESR1/FOXA1/GATA3-high luminal profile, low TMB, high ESR1 promoter methylation. | A | TCGA-EW-A1J6 | condensed_caption:genomic_findings | [
"data/features/features_uni/TCGA-EW-A1J6-01Z-00-DX1.F668E978-13B6-4284-9522-37C65C57A21A.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk9/pngs/TCGA-BRCA/TCGA-EW-A1J6/1.3.6.1.4.1.14519.5.2.1.1869.4002.108214931724014572767522872903/1.3.6.1.4.1.14519.5.2.1.1869.4002.118850153407444363131902629868",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-EW-A1J6-01A__5d56e68a-eab1-434b-af69-f887eace7502.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-EW-A1J6__d7e1d1f4-3189-401d-91dc-048ab13ce5df.pt | |||||
TCGA-EW-A1J6 | TCGA-BRCA | 6,661,072,980,427,015,000 | 728,239,711,647,829,200 | train | mcq | from_caption | caption_integrated | integrated_interpretation | all_available | true | true | true | true | Which integrated interpretation best matches this case? | Invasive infiltrative breast carcinoma with concordant spiculated MRI and fat-entrapping desmoplastic histology, plus copy-number-quiet HR-proficient luminal biology. | Invasive ductal-phenotype luminal carcinoma with desmoplastic fat-infiltrating tubular/cord architecture and hypermutated PIK3CA-mutant, TP53-wild-type profile. | Invasive gland-forming carcinoma through fibrofatty tissue with genomically quiet, ER-associated luminal program and discordant luminal subclassification. | Luminal breast carcinoma uniquely combining papillary invasive morphology, lymphoid-rich stroma, and low-burden genomically quiet GATA3-disrupted biology. | Invasive infiltrative breast carcinoma with concordant spiculated MRI and fat-entrapping desmoplastic histology, plus copy-number-quiet HR-proficient luminal biology. | A | TCGA-EW-A1J6 | condensed_caption:integrated_interpretation | [
"data/features/features_uni/TCGA-EW-A1J6-01Z-00-DX1.F668E978-13B6-4284-9522-37C65C57A21A.h5"
] | [
"data/features/features_radiology/radiology_features.h5::series=data/processes/radiology/chunk9/pngs/TCGA-BRCA/TCGA-EW-A1J6/1.3.6.1.4.1.14519.5.2.1.1869.4002.108214931724014572767522872903/1.3.6.1.4.1.14519.5.2.1.1869.4002.118850153407444363131902629868",
"data/features/features_radiology/radiology_features.h5::s... | data/features/features_cpgpt_dnam/TCGA-BRCA/TCGA-EW-A1J6-01A__5d56e68a-eab1-434b-af69-f887eace7502.pt | data/features/features_bulkformer_rna/TCGA-BRCA/TCGA-EW-A1J6__d7e1d1f4-3189-401d-91dc-048ab13ce5df.pt |
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