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TITLE: Addressing Patients' Alcohol Consumption-A Population-Based Survey of Patient Experiences.. ABSTRACT: Objectives: To identify the proportion of the population that had experienced that alcohol was addressed in health care the previous year, to explore experiences and perceived effects of addressing alcohol, and ...
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TITLE: The Syndrome of Large Healed Single Discrete Myocardial Infarct with Severe Narrowing of Only One Major Epicardial Coronary Artery and Leading to Severe Chronic Heart Failure and Orthotopic Heart Transplantation.. ABSTRACT: Described herein are clinical and cardiac morphologic findings in 12 patients (age 43 to ...
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TITLE: Effect of a Multidisciplinary Pulmonary Embolism Response Team on Patient Mortality.. ABSTRACT: Multidisciplinary Pulmonary Embolism Response Teams (PERTs) may improve the care of patients with a high risk of pulmonary embolism (PE). The impact of a PERT on long-term mortality has never been evaluated. An observ...
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TITLE: Relations Between Cardiac Magnetic Resonance Imaging-Derived Left Ventricular Mass, Early Repolarization, and Cardiovascular Events (from the Dallas Heart Study).. ABSTRACT: Early repolarization pattern (ERP) is associated with increased mortality in case-control studies, but the mechanism and role of left ventr...
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TITLE: Outcomes in Patients Stratified by PRECISE-DAPT Versus DAPT Scores After Percutaneous Coronary Interventions.. ABSTRACT: The optimal length of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) remains debated. Current guidelines recommend individualized treatment with consideration ...
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TITLE: Long-Term Prognostic Implications and Role of Further Testing in Adults Aged ?55 Years With a Coronary Calcium Score of Zero (from the Multi-Ethnic Study of Atherosclerosis).. ABSTRACT: The long-term prognostic significance of a coronary artery calcium (CAC) score of 0 is poorly defined in younger adults. We eva...
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TITLE: Gaps and Disparities in Primary Prevention Statin Prescription During Outpatient Care.. ABSTRACT: The 2018 American College of Cardiology/American Heart Association Guideline on the Management of Blood Cholesterol recommends statin therapy for eligible patients to reduce the risk of atherosclerotic cardiovascula...
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TITLE: Comparison of Outcomes of Catheter Ablation in Asymptomatic Versus Symptomatic Preexcitation to Guidelines and Beyond.. ABSTRACT: Management of asymptomatic subjects with preexcitation remains controversial. Our objective was to analyze the reasons an electrophysiological study (EPS) was performed in an asymptom...
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TITLE: Proteomics and Risk of Atrial Fibrillation in Older Adults (From the Atherosclerosis Risk in Communities [ARIC] Study).. ABSTRACT: Plasma proteomic profiling may aid in the discovery of novel biomarkers upstream of the development of atrial fibrillation (AF). We used data from the Atherosclerosis Risk in Communi...
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TITLE: Relation of Type 2 Myocardial Infarction and Readmission With Type 1 Myocardial Infarction in Hypertensive Crises (from a Nationwide Analysis).. ABSTRACT: Type 2 myocardial infarction (T2MI) is an ischemic injury that occurs due to a mismatch between myocardial oxygen supply and demand. T2MI can occur with hyper...
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TITLE: Incidence, Predictive Factors, and Prognostic Impact of Right Ventricular Dysfunction Before Transcatheter Aortic Valve Implantation.. ABSTRACT: Right ventricular dysfunction (RVD) is considered to be a late marker of aortic stenosis. However, there is a lack of consensus regarding the incidence, prognostic impa...
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TITLE: Clinical and Hemodynamic Effects of Percutaneous Edge-to-Edge Mitral Valve Repair in Atrial Versus Ventricular Functional Mitral Regurgitation.. ABSTRACT: The present study aims to assess the clinical and hemodynamic impact of percutaneous edge-to-edge mitral valve repair with MitraClip in patients with atrial f...
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TITLE: Acute Kidney Injury and Renal Replacement Therapy After Fontan Operation.. ABSTRACT: Fontan circulation leads to chronic elevation of central venous pressure. We sought to identify the incidence, risk factors, and survival among patients who developed acute kidney injury (AKI) after the Fontan operation. We retr...
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TITLE: Perinatal outcomes of pregnant women having SARS-CoV-2 infection.. ABSTRACT: OBJECTIVES: Aim of this study is to evaluate the prognosis of pregnant women having SARS-CoV-2 infection and investigate whether there was a difference in perinatal outcomes between pregnant women who had SARS-CoV-2 infection and those ...
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TITLE: Prescription opioid treatment for non-cancer pain and initiation of injection drug use: large retrospective cohort study.. ABSTRACT: OBJECTIVE: To assess the association between long term prescription opioid treatment medically dispensed for non-cancer pain and the initiation of injection drug use (IDU) among in...
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TITLE: Depression, anxiety, PTSD, and OCD after stillbirth: a systematic review.. ABSTRACT: BACKGROUND: This systematic review aimed to provide an updated summary of studies investigating depression, anxiety, post-traumatic stress disorder (PTSD), and obsessive-compulsive disorder (OCD) in parents after stillbirth (fro...
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TITLE: Which elements were significant in reducing obstetric anal sphincter injury? A prospective follow-up study.. ABSTRACT: BACKGROUND: To examine which elements of an obstetric anal sphincter injury (OASI) care bundle were protective for OASI. Several interventional trials showed that application of a care bundle in...
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TITLE: Association between ambient air pollutants and meteorological factors with SARS-CoV-2 transmission and mortality in India: an exploratory study.. ABSTRACT: BACKGROUND: The Coronavirus disease 2019 (COVID-19) pandemic poses a serious public health concern worldwide. Certain regions of the globe were severely affe...
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TITLE: The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation.. ABSTRACT: Several studies of patients with COVID-19 have evaluated biological markers for predicting outcomes, most of them retrospectively and with a wide scope...
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TITLE: Effectiveness of vaccination against SARS-CoV-2 infection and Covid-19 hospitalisation among Finnish elderly and chronically ill-An interim analysis of a nationwide cohort study.. ABSTRACT: BACKGROUND: In Finland, both mRNA and adenovirus vector (AdV) Covid-19 vaccines have been used after the vaccination campai...
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TITLE: Recombinant production of a functional SARS-CoV-2 spike receptor binding domain in the green algae Chlamydomonas reinhardtii.. ABSTRACT: Recombinant production of viral proteins can be used to produce vaccine antigens or reagents to identify antibodies in patient serum. Minimally, these proteins must be correctl...
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TITLE: Surveying the local public health response to COVID-19 in Canada: Study protocol.. ABSTRACT: BACKGROUND: Public health services and systems research is under-developed in Canada and this is particularly the case with respect to research on local public health unit operational functioning and capacity. The purpos...
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TITLE: Relationship among state reopening policies, health outcomes and economic recovery through first wave of the COVID-19 pandemic in the U.S.. ABSTRACT: State governments in the U.S. have been facing difficult decisions involving tradeoffs between economic and health-related outcomes during the COVID-19 pandemic. D...
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TITLE: Nanopore metagenomic sequencing for detection and characterization of SARS-CoV-2 in clinical samples.. ABSTRACT: OBJECTIVES: The COVID-19 pandemic has underscored the need for rapid novel diagnostic strategies. Metagenomic Next-Generation Sequencing (mNGS) may allow for the detection of pathogens that can be mis...
124
TITLE: Modelling digital and manual contact tracing for COVID-19. Are low uptakes and missed contacts deal-breakers?. ABSTRACT: Comprehensive testing schemes, followed by adequate contact tracing and isolation, represent the best public health interventions we can employ to reduce the impact of an ongoing epidemic when...
125
TITLE: The impact of pandemic-related worry on cognitive functioning and risk-taking.. ABSTRACT: Here, we sought to quantify the effects of experienced fear and worry, engendered by the COVID-19 pandemic, on both cognitive abilities-speed of information processing, task-set shifting, and proactive control-as well as ec...
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TITLE: The Impact of Disease Control Measures on the Spread of COVID-19 in the Province of Sindh, Pakistan.. ABSTRACT: The province of Sindh reported the first COVID-19 case in Pakistan on 26th February 2020. The Government of Sindh has employed numerous control measures to limit its spread. However, for low-and middle...
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TITLE: Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction.. ABSTRACT: SARS-CoV-2 viral attachment and entry into host cells is mediated by a direct interaction between viral spike glycoproteins and membrane bound...
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TITLE: COVID-19 preventive practices during intrapartum care- adherence and barriers in Ethiopia; a multicenter cross- sectional study.. ABSTRACT: BACKGROUND: Coronavirus disease 19 (COVID-19) is a newly emerging pandemic affecting more than 120 million people globally. Compliance with preventive practices is the singl...
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TITLE: Lessons learned from the rapid development of a statewide simulation model for predicting COVID-19's impact on healthcare resources and capacity.. ABSTRACT: The first case of COVID-19 was detected in North Carolina (NC) on March 3, 2020. By the end of April, the number of confirmed cases had soared to over 10,00...
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TITLE: Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections.. ABSTRACT: Severe acute respiratory coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is of zoonotic origin. Evolutionary analyses assessing whether coronaviruses similar to SARS-CoV-2 infected ances...
131
TITLE: A New Framework for Practice-Academic Partnerships During the Pandemic-and into the Future.. ABSTRACT: ABSTRACT: During the COVID-19 pandemic, many health care facilities closed their doors to nursing students, depriving them of the experience of caring for patients, a foundation of nursing education. The purpos...
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TITLE: Nurses Spreading Misinformation.. ABSTRACT: ABSTRACT: Nurses are trusted to be truthful and to provide considered, substantiated information in a neutral way. Yet the COVID-19 crisis has highlighted how some nurses engage in misinformation on social media and in other venues. This article explores the reasons wh...
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TITLE: Create a COVID-19 commission.. ABSTRACT: [Figure: see text].
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TITLE: Impact of Hospital Strain on Excess Deaths During the COVID-19 Pandemic - United States, July 2020-July 2021.. ABSTRACT: Surges in COVID-19 cases have stressed hospital systems, negatively affected health care and public health infrastructures, and degraded national critical functions (1,2). Resource limitations...
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TITLE: Health Care Access and Use Among Adults with Diabetes During the COVID-19 Pandemic - United States, February-March 2021.. ABSTRACT: Diabetes affects approximately one in 10 persons in the United States† and is a risk factor for severe COVID-19 (1), especially when a patient's diabetes is not well managed (2). Th...
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TITLE: Prevalence and Characteristics of Subjective Cognitive Decline Among Unpaid Caregivers Aged ?45 Years - 22 States, 2015-2019.. ABSTRACT: Approximately 20% of U.S. adults are unpaid caregivers (caregivers) (1) who provide support to a family member or friend with a health condition or disability. Although there a...
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TITLE: Incidence of SARS-CoV-2 Infection, Emergency Department Visits, and Hospitalizations Because of COVID-19 Among Persons Aged ?12 Years, by COVID-19 Vaccination Status - Oregon and Washington, July 4-September 25, 2021.. ABSTRACT: Population-based rates of infection with SARS-CoV-2 (the virus that causes COVID-19)...
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TITLE: Automated Digital Notification of COVID-19 Diagnoses Through Text and Email Messaging - North Carolina, December 2020-January 2021.. ABSTRACT: During October 3, 2020-January 9, 2021, North Carolina experienced a 400% increase in daily reported COVID-19 cases (1). To handle the increased number of cases and rapid...
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TITLE: Colon Capsule Endoscopy in the Assessment of Mucosal Healing in Crohn's Disease.. ABSTRACT: BACKGROUND: Patients with Crohn's disease (CD) undergo frequent endoscopic procedures, with visualization of the gastrointestinal mucosa central to treatment decision-making. Subsequently, a noninvasive alternative to opt...
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TITLE: Zn-Induced Interactions Between SARS-CoV-2 orf7a and BST2/Tetherin.. ABSTRACT: We present in this work a first X-ray Absorption Spectroscopy study of the interactions of Zn with human BST2/tetherin and SARS-CoV-2 orf7a proteins as well as with some of their complexes. The analysis of the XANES region of the meas...
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TITLE: In the eye of the storm: impact of COVID-19 pandemic on admission patterns to paediatric intensive care units in the UK and Eire.. ABSTRACT: BACKGROUND: The coronavirus disease-19 (COVID-19) pandemic had a relatively minimal direct impact on critical illness in children compared to adults. However, children and ...
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TITLE: Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: systematic review and meta-analysis.. ABSTRACT: OBJECTIVE: To review the evidence on the effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transm...
143
TITLE: The role of absolute humidity in respiratory mortality in Guangzhou, a hot and wet city of South China.. ABSTRACT: BACKGROUND: For the reason that many studies have been inconclusive on the effect of humidity on respiratory disease, we examined the association between absolute humidity and respiratory disease mo...
144
TITLE: Prevalence of SARS-CoV-2 antibodies in hemodialysis patients in Senegal: a multicenter cross-sectional study.. ABSTRACT: BACKGROUND: Hemodialysis patients are among high-risk groups for COVID-19. Africa is the continent with the lowest number of cases in the general population but we have little information abou...
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TITLE: The Impact of IFNë4 on the Adaptive Immune Response to SARS-CoV-2 Infection.. ABSTRACT: Genetic polymorphisms at the IFNL4 loci are known to influence the clinical outcome of several different infectious diseases. Best described is the association between the IFNL4 genotype and hepatitis C virus clearance. Howev...
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TITLE: Infection in asymptomatic carriers of SARS-CoV-2 can interfere with the achievement of robust immunity on a population scale.. ABSTRACT: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread worldwide as a severe pandemic, and a significant portion of the infected population may re...
147
TITLE: Food, nutrition and cancer: perspectives and experiences of New Zealand cancer survivors.. ABSTRACT: AIM: This research sought to understand and describe cancer survivors' perspectives and post-diagnosis experiences of food and nutrition, with a particular focus on barriers to healthy eating, health equity, and ...
148
TITLE: Breast cancer costs in New Zealand's public health system.. ABSTRACT: AIM: This study aims to estimate the mean costs of breast cancer in New Zealand's public health system.METHOD: This study included women diagnosed with invasive breast cancer between 1 July 2010 and 30 June 2018 who received services in public...
149
TITLE: Use and results of systemic treatments for de novo and recurrent metastatic breast cancer: a population-based cohort study.. ABSTRACT: AIMS: To describe the systemic treatments in patients with de novo metastatic breast cancer (dnMBC, initial metastatic diagnosis) and recurrent metastatic breast cancer (rMBC).ME...
150
TITLE: Barriers to physical activity in prostate cancer survivors.. ABSTRACT: AIMS: Despite the benefits of regular physical activity (PA), many prostate cancer (PCa) survivors are not engaging in sufficient PA to achieve health-related gain. This qualitative study sought to gain further insight regarding barriers to P...
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TITLE: He Pikinga Waiora Kimi Ora lifestyle programme: case study of a successful community-based Indigenous diabetes intervention.. ABSTRACT: AIM: To co-design and implement a wh?nau-centred, community-based lifestyle programme (Kimi Ora) intended to ensure no worsening of HbA1c and to improve wellbeing for M?ori wh?n...
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TITLE: Addressing equity: a 10-year review of strabismus surgery in 0-19-year-olds in the New Zealand public health system.. ABSTRACT: BACKGROUND: This study aimed to identify the relationship between the incidence of strabismus surgery, ethnicity and socioeconomic deprivation in the New Zealand public health system. S...
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TITLE: A distance-based approach to rurality and remoteness in health: concept, methodology and correlates of a patient-centred health services spatial accessibility index.. ABSTRACT: AIM: To develop a distance-based index of patients' spatial accessibility to healthcare services as a quantifiable basis for analysing h...
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TITLE: Quality of life after oesophageal stenting in patients with palliative oesophageal cancer.. ABSTRACT: AIM: Patients with incurable oesophageal cancer have poor outcomes, with disabling symptoms and a poor quality of life (QOL), which may be improved by oesophageal stenting. We aimed to measure change in symptoms...
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TITLE: Testing for dihydropyrimidine dehydrogenase deficiency in New Zealand to improve the safe use of 5-fluorouracil and capecitabine in cancer patients.. ABSTRACT: Dihydropyrimidine dehydrogenase deficiency is a rare inherited disorder. Approximately 3% of people of European ancestry are likely to have a partial def...
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TITLE: Pheochromocytoma in pregnancy: a case report.. ABSTRACT: A case of large 11cm phaeochromocytoma at 35 weeks with preceding diagnoses of pre-eclampsia and gestational diabetes (GDM), which confounded initial management.
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TITLE: Representativeness of individual-level data in COVID-19 phone surveys: Findings from Sub-Saharan Africa.. ABSTRACT: The COVID-19 pandemic has created urgent demand for timely data, leading to a surge in mobile phone surveys for tracking the impacts of and responses to the pandemic. Using data from national phone...
158
TITLE: The effects of quality of evidence communication on perception of public health information about COVID-19: Two randomised controlled trials.. ABSTRACT: BACKGROUND: The quality of evidence about the effectiveness of non-pharmaceutical health interventions is often low, but little is known about the effects of co...
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TITLE: Individual determinants of COVID-19 vaccine hesitancy.. ABSTRACT: BACKGROUND: Novel coronavirus disease 2019 (COVID-19) vaccine hesitancy is a barrier to achieving herd immunity, and thus, a prominent public health concern. This study aimed to identify the determinants of COVID-19 vaccine hesitancy based on the ...
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TITLE: Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection.. ABSTRACT: BACKGROUND: Coronavirus disease 2019 (COVID-19) is associated with endothelial activation and coagulopathy, which may be related to pre-existing or infection-induced pro-thrombotic autoantibodies such as those targeting angioten...
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TITLE: COVID-19 vaccine uptake and hesitancy survey in Northern Ireland and Republic of Ireland: Applying the theory of planned behaviour.. ABSTRACT: The Coronavirus Disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first appeared in Wuhan, China in late 2019 and since then has c...
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TITLE: School reopening and risks accelerating the COVID-19 pandemic: A systematic review and meta-analysis protocol.. ABSTRACT: BACKGROUND: One of the most recent concerns of this pandemic regards the role of schools reopening in disease transmission, as well as the impact of keeping schools closed. While school reope...
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TITLE: Evaluation of the United States COVID-19 vaccine allocation strategy.. ABSTRACT: BACKGROUND: Anticipating an initial shortage of vaccines for COVID-19, the Centers for Disease Control (CDC) in the United States developed priority vaccine allocations for specific demographic groups in the population. This study e...
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TITLE: Analysis of Hip Fractures in France During the First COVID-19 Lockdown in Spring 2020.. ABSTRACT: Importance: The COVID-19 pandemic has posed a number of unprecedented challenges to the health care system in France, where hip fractures in the elderly population are a major public health concern.Objective: To exp...
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TITLE: Clearing the air about airborne transmission of SARS-CoV-2.. ABSTRACT: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has created the current pandemic, has caused a worldwide worry. Different countries have since enforced varying levels of lockdowns and guidelines for their populations to ...
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TITLE: Mortality prediction with CHA2DS2-VASc, CHA2DS2-VASc-HS and R2CHA2DS2-VASc score in patients hospitalized due to COVID-19.. ABSTRACT: OBJECTIVE: We aimed to test the efficiency of CHA2DS2-VASc, CHA2DS2-VASc-HS, R2CHA2DS2-VASc score systems on the prediction of mortality in the patients with COVID-19.PATIENTS AND...
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TITLE: Association between platelet indices and the severity of the disease and mortality in patients with COVID-19.. ABSTRACT: OBJECTIVE: The aim of the study was to determine the association between platelet indices and disease severity, and outcomes of the patients with severe acute respiratory syndrome coronavirus ...
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TITLE: A meta-regression study of the clinical significance of serum aminotransferases in COVID-19.. ABSTRACT: OBJECTIVE: The aim of the study was to appraise the capacity of serum aminotransferases to discriminate between hepatic and other extra-pulmonary COVID-19-related manifestations and, potentially, to serve as p...
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TITLE: In silico molecular docking studies of certain commercially available flavonoids as effective antiviral agents against spike glycoprotein of SARS-CoV-2.. ABSTRACT: OBJECTIVE: Coronaviruses are large, enveloped, positive-stranded RNA viruses. These viruses contain spike-like projections of glycoprotein on their s...
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TITLE: Adapting evaluation method of skills acquisition in basic cardiopulmonary resuscitation among year 5 and year 6 primary school pupils during the COVID-19 lockdown: a pilot study.. ABSTRACT: OBJECTIVE: This longitudinal descriptive study aimed to evaluate cognitive skills acquisition in basic Cardiopulmonary Resu...
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TITLE: Acute severe SARS COVID-19 patients produce pro-resolving lipids mediators and eicosanoids.. ABSTRACT: OBJECTIVE: This study aimed to evaluate the eicosanoid and pro resolutive parameters in SARS COVID-19 patients with the severe acute respiratory syndrome.PATIENTS AND METHODS: Fourteen male patients with an acu...
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TITLE: Investigating potency of TMC-126 against wild-type and mutant variants of HIV-1 protease: a molecular dynamics and free energy study.. ABSTRACT: A detailed computational study was performed to investigate the conformational changes of flap region and the mechanism underlying the binding of the inhibitor TMC-126 ...
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TITLE: Sources of Distress and Coping Strategies Among Emergency Physicians During COVID-19.. ABSTRACT: INTRODUCTION: The coronavirus disease 2019 (COVID-19) pandemic has been shown to increase levels of psychological distress among healthcare workers. Little is known, however, about specific positive and negative indi...
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TITLE: A Dispatch Screening Tool to Identify Patients at High Risk for COVID-19 in the Prehospital Setting.. ABSTRACT: INTRODUCTION: Emergency medical services (EMS) dispatchers have made efforts to determine whether patients are high risk for coronavirus disease 2019 (COVID-19) so that appropriate personal protective ...
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TITLE: Clinical Characteristics Associated with Return Visits to the Emergency Department after COVID-19 Diagnosis.. ABSTRACT: INTRODUCTION: Patients diagnosed with coronavirus disease 2019 (COVID-19) require significant healthcare resources. While published research has shown clinical characteristics associated with s...
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TITLE: Viral Coinfection is Associated with Improved Outcomes in Emergency Department Patients with SARS-CoV-2.. ABSTRACT: INTRODUCTION: Coinfection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) and another virus may influence the clinical trajectory of emergency department (ED) patients. However, l...
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TITLE: COVID-19 Risk Factors and Mortality Outcomes Among Medicare Patients Receiving Long-term Dialysis.. ABSTRACT: Importance: There is a need for studies to evaluate the risk factors for COVID-19 and mortality among the entire Medicare long-term dialysis population using Medicare claims data.Objective: To identify r...
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TITLE: Impact of COVID-19 Pandemic on Gastroenterology Fellowship Training in Turkey: A Prospective Nationwide Survey Study.. ABSTRACT: BACKGROUND: The Coronavirus-2019 disease (COVID-19) pandemic has markedly restricted endoscopic and clinical activities in gastroenterology (GI), with a negative impact on trainee educ...
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TITLE: The voice of those who provide care during the pandemic - a lexicographic study in Brazil-Portugal.. ABSTRACT: OBJECTIVE: To analyze the most frequent words in interviews given by nurses during the coronavirus pandemic.METHOD: This is a qualitative, exploratory, descriptive study, carried out with 45 interviews ...
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TITLE: Thromboembolic Rates Are Similar Between Intensive Care Unit and Nonintensive Care Unit Hospitalized Patients With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Retrospective Cohort Study.. ABSTRACT: High rates of thromboembolic events have been described in intensive care unit (ICU) patients. ...
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TITLE: Sex differences in mortality among binational cohort of people with chronic kidney disease: population based data linkage study.. ABSTRACT: OBJECTIVE: To evaluate sex differences in mortality among people with kidney failure compared with the general population.DESIGN: Population based cohort study using data li...
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TITLE: OpenSAFELY: impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic.. ABSTRACT: BACKGROUND: Early in the COVID-19 pandemic, the National Health Service (NHS) recommended that appropriate patients anticoagulated with warfarin should be switched to direct-acting oral anticoagulants ...
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TITLE: Acute mental health service use following onset of the COVID-19 pandemic in Ontario, Canada: a trend analysis.. ABSTRACT: BACKGROUND: The extent to which heightened distress during the COVID-19 pandemic translated to increases in severe mental health outcomes is unknown. We examined trends in psychiatric present...
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TITLE: Discrimination experienced by Asian Canadian and Asian American health care workers during the COVID-19 pandemic: a qualitative study.. ABSTRACT: BACKGROUND: Asian Canadians and Asian Americans face COVID-19-related discrimination. The objective of this qualitative study was to explore the experiences of Asian h...
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TITLE: The mental well-being and coping strategies of Canadian adolescents during the COVID-19 pandemic: a qualitative, cross-sectional study.. ABSTRACT: BACKGROUND: Qualitative research is lacking on the mental well-being of adolescents during the COVID-19 pandemic. The aim of this study was to explore the feelings an...
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TITLE: The Impact of the COVID-19 Pandemic on Depression and Sexual Function: Are Pregnant Women Affected More Adversely?. ABSTRACT: OBJECTIVE:  To investigate depression and sexual function among pregnant and non-pregnant women throughout the COVID-19 pandemic.METHODS:  A total of 188 women, 96 pregnant and 92 non-pre...
187
TITLE: Assessment of gentamicin and cisplatin-induced kidney damage mediated via necrotic and apoptosis genes in albino rats.. ABSTRACT: BACKGROUND: Gentamicin (GM) is a low-cost, low-resistance antibiotic commonly used to treat gram-negative bacterial diseases. Cisplatin (Csp) is a platinum-derived anti-neoplastic age...
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TITLE: Effects of Saccharomyces cerevisiae cell wall addition on feed digestibility, fecal fermentation and microbiota and immunological parameters in adult cats.. ABSTRACT: BACKGROUND: This study aimed to evaluate the effects of increasing dosages of a commercial product composed by Saccharomyces cerevisiae yeast (YAM...
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TITLE: Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units.. ABSTRACT: BACKGROUND: Clinical metagenomics (CMg) has the potential to be translated from a research tool into routine service to ...
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TITLE: Online residency training during the COVID-19 pandemic: a national survey of otolaryngology head and neck surgery program directors.. ABSTRACT: BACKGROUND: The COVID-19 pandemic has deeply impacted healthcare and education systems, including resident education. The impact of the pandemic on the different types o...
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TITLE: Vaccine Design by Reverse Vaccinology and Machine Learning.. ABSTRACT: Reverse vaccinology (RV) is the state-of-the-art vaccine development strategy that starts with predicting vaccine antigens by bioinformatics analysis of the whole genome of a pathogen of interest. Vaxign is the first web-based RV vaccine pred...
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TITLE: Application of Reverse Vaccinology and Immunoinformatic Strategies for the Identification of Vaccine Candidates Against Shigella flexneri.. ABSTRACT: Reverse vaccinology (RV) was first introduced by Rappuoli for the development of an effective vaccine against serogroup B Neisseria meningitidis (MenB). With the a...
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TITLE: Purification of Prospective Vaccine Antigens from Gram-Positive Pathogens by Immunoprecipitation.. ABSTRACT: Immunoprecipitation is an affinity purification technique that exploits the highly specific interactions formed between antibodies and their cognate antigens to purify molecules of interest from complex b...
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TITLE: Rapid Surface Shaving for Proteomic Identification of Novel Surface Antigens for Vaccine Development.. ABSTRACT: The bacterial cell surface (surfaceome) is the first site encountered by immune cells and is thus an important site for immune recognition. As such, the characterization of bacterial surface proteins ...
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TITLE: Two-Dimensional Electrophoresis Coupled with Western Blot as a Method to Detect Potential Neutralizing Antibody Targets from Gram-Negative Intracellular Bacteria.. ABSTRACT: Antigen selection is a critical step in subunit vaccine design, especially if the goal is to identify antigens that can be bound by neutral...
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TITLE: Panproteome Analysis of the Human Antibody Response to Bacterial Vaccines and Challenge.. ABSTRACT: High-density protein microarray is an established technology for characterizing host antibody profiles against entire pathogen proteomes. As one of the highest throughput technologies for antigen discovery, proteo...
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TITLE: Low-Energy Electron Irradiation (LEEI) for the Generation of Inactivated Bacterial Vaccines.. ABSTRACT: Vaccines consisting of whole inactivated bacteria (bacterins) are generated by incubation of the pathogen with chemicals. This is a time-consuming procedure which may lead to less immunogenic material, as crit...
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TITLE: Design and Production of Hybrid Antigens for Targeting Integral Outer Membrane Proteins in Gram-Negative Bacteria.. ABSTRACT: Metal ion transporters in the outer membrane of gram-negative bacteria that are responsible for acquiring iron and zinc are attractive vaccine targets due to their essential function. The...
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TITLE: Preparation of Trimethyl Chitosan-Based Polyelectrolyte Complexes for Peptide Subunit Vaccine Delivery.. ABSTRACT: A variety of delivery vehicles have been explored as adjuvanting/delivery platforms for peptide-based subunit vaccines. Polysaccharide-based systems have been found to be especially attractive due t...